Search Results - "Polzella, Paolo"

Results of a national UK physician reported survey of COVID-19 infection in patients with a myeloproliferative neoplasm by Salisbury, Richard A., Curto-Garcia, Natalia, O’Sullivan, Jennifer, Chen, Frederick, Polzella, Paolo, Godfrey, Anna L., Russell, James, Knapper, Steven, Willan, John, Frewin, Rebecca, Joshi, Shivani, Arami, Siamak, Burns, Sarah, Teh, Chun Huat, Wadelin, Frances, Dhanapal, Jaymathi, Neelakantan, Pratap, Milojkovic, Dragana, Psaila, Beth, Szydlo, Richard, Francis, Sebastian, Cargo, Catherine, Jain, Manish, McGregor, Andrew, Wallis, Louise, Duncombe, Andrew, Hussein, Hayder, Dyer, Peter, Munro, Laura, Bond, Lee, McMullin, Mary Frances, Somervaille, Tim C. P., Garg, Mamta, Sekhar, Mallika, Harrison, Claire, Mead, Adam J., Innes, Andrew J.

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Modulation of Human Natural Killer T Cell Ligands on TLR-Mediated Antigen-Presenting Cell Activation by Salio, Mariolina, Speak, Anneliese O., Shepherd, Dawn, Polzella, Paolo, Illarionov, Petr A., Veerapen, Natacha, Besra, Gurdyal S., Platt, Frances M., Cerundolo, Vincenzo

“…Invariant natural killer T (iNKT) cells are a subset of nonconventional T cells recognizing endogenous and/or exogenous glycolipid antigens in the context of…”
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Validation of clinical‐grade whole genome sequencing reproduces cytogenetic analysis and identifies mutational landscape in newly‐diagnosed multiple myeloma patients: A pilot study from the 100,000 Genomes Project by Lomas, Oliver C., Gooding, Sarah, Cabes, Maite, Dreau, Helene, Wilson, Edward, Polzella, Paolo, Ramasamy, Karthik, Hamblin, Angela D.

“…Multiple myeloma is characterized by chromosomal abnormalities and genetic variation, which may inform prognosis and guide treatment. This pilot study sought…”
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Cutting Edge: Nonglycosidic CD1d Lipid Ligands Activate Human and Murine Invariant NKT Cells by Silk, Jonathan D, Salio, Mariolina, Reddy, B. Gopal, Shepherd, Dawn, Gileadi, Uzi, Brown, James, Masri, S. Hajar, Polzella, Paolo, Ritter, Gerd, Besra, Gurdyal S, Jones, E. Yvonne, Schmidt, Richard R, Cerundolo, Vincenzo

“…Invariant NKT cells (iNKT cells) recognize CD1d/glycolipid complexes. We demonstrate that the nonglycosidic compound threitolceramide efficiently activates…”
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Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction by Nika, Konstantina, Soldani, Cristiana, Salek, Mogjiborahman, Paster, Wolfgang, Gray, Adrian, Etzensperger, Ruth, Fugger, Lars, Polzella, Paolo, Cerundolo, Vincenzo, Dushek, Omer, Höfer, Thomas, Viola, Antonella, Acuto, Oreste

“…T cell antigen receptor (TCR) and coreceptor ligation is thought to initiate signal transduction by inducing activation of the kinase Lck. Here we showed that…”
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CD169+ macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes by Barral, Patricia, Polzella, Paolo, Bruckbauer, Andreas, van Rooijen, Nico, Besra, Gurdyal S, Cerundolo, Vincenzo, Batista, Facundo D

“…How and where invariant natural killer T cells encounter glycolipids in vivo remains unclear. Batista and colleagues use multiphoton microscopy to show that…”
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Intravenous iron therapy results in rapid and sustained rise in myocardial iron content through a novel pathway by Vera-Aviles, Mayra, Kabir, Syeeda Nashitha, Shah, Akshay, Polzella, Paolo, Lim, Dillon Yee, Buckley, Poppy, Ball, Charlotte, Swinkels, Dorine, Matlung, Hanke, Blans, Colin, Holdship, Philip, Nugent, Jeremy, Anderson, Edward, Desborough, Michael, Piechnik, Stefan, Ferreira, Vanessa, Lakhal-Littleton, Samira

“…Intravenous iron therapies contain iron-carbohydrate complexes, designed to ensure iron becomes bioavailable via the intermediary of spleen and liver…”
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How do we use electronic clinical decision support and feedback to promote good transfusion practice by Staples, Sophie, Salisbury, Richard A., King, Andrew J., Polzella, Paolo, Bakhishli, Gardash, Staves, Julie, Murphy, Michael F.

“…This report describes the evolution of the electronic clinical decision support system (CDSS) and feedback methods at our center and the challenges and lessons…”
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Regional outcomes of severe acute respiratory syndrome coronavirus 2 infection in hospitalised patients with haematological malignancy by Booth, Stephen, Willan, John, Wong, Henna, Khan, Dalia, Farnell, Rachel, Hunter, Alicia, Eyre, Toby, Katz, Harley, Dungarwalla, Moez, Chen, Lucia, Browning, Joe, Polzella, Paolo, Gray, Nicola, Neelakantan, Pratap, Dhillon, Elissa K., Dutton, David, Sternberg, Alex, Prideaux, Steven, Collins, Graham P., Peniket, Andy

“…Objectives We sought to characterise the outcomes of patients with haematological malignancy and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)…”
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Real world reduction in red cell transfusion with restrictive transfusion threshold in haematology inpatients by Pervaiz, Omer, Dhanapal, Jay, Pillai, Lakshmi, Pavord, Sue, Leary, Heather, Eyre, Toby, Peniket, Andrew, Staves, Julie, Polzella, Paolo, Desborough, Michael J. R.

“…Objectives The aim of this study was to assess the reduction in red cell transfusions following a change in the red cell transfusion threshold for haematology…”
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Binding Strength and Dynamics of Invariant Natural Killer Cell T Cell Receptor/CD1d-Glycosphingolipid Interaction on Living Cells by Single Molecule Force Spectroscopy by Bozna, Bianca L., Polzella, Paolo, Rankl, Christian, Zhu, Rong, Salio, Mariolina, Shepherd, Dawn, Duman, Memed, Cerundolo, Vincenzo, Hinterdorfer, Peter

“…Invariant natural killer T (iNKT) cells are a population of T lymphocytes that play an important role in regulating immunity to infection and tumors by…”
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Design, Synthesis, and Functional Activity of Labeled CD1d Glycolipid Agonists by Jervis, Peter J, Polzella, Paolo, Wojno, Justyna, Jukes, John-Paul, Ghadbane, Hemza, Garcia Diaz, Yoel R, Besra, Gurdyal S, Cerundolo, Vincenzo, Cox, Liam R

“…Invariant natural killer T cells (iNKT cells) are restricted by CD1d molecules and activated upon CD1d-mediated presentation of glycolipids to T cell receptors…”
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Nanomapping of CD1d-glycolipid complexes on THP1 cells by using simultaneous topography and recognition imaging by Duman, Memed, Chtcheglova, Lilia A., Zhu, Rong, Bozna, Bianca L., Polzella, Paolo, Cerundolo, Vicenzo, Hinterdorfer, Peter

“…CD1d molecule, a monomorphic major histocompatibility complex class I‐like molecule, presents different types of glycolipids to invariant natural killer T…”
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CD169 + macrophages present lipid antigens to mediate early activation of i NKT cells in lymph nodes by Cerundolo, Vincenzo, Batista, Facundo D, Barral, Patricia, Polzella, Paolo, Bruckbauer, Andreas, van Rooijen, Nico, Besra, Gurdyal S

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CD169 super(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes by Barral, Patricia, Polzella, Paolo, Bruckbauer, Andreas, van Rooijen, Nico, Besra, Gurdyal S, Cerundolo, Vincenzo, Batista, Facundo D

“…Invariant natural killer T cells (iNKT cells) are involved in the host defense against microbial infection. Although it is known that iNKT cells recognize…”
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macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes by Barral, Patricia, Polzella, Paolo, Bruckbauer, Andreas, van Rooijen, Nico, Besra, Gurdyal S, Cerundolo, Vincenzo, Batista, Facundo D

“…Invariant natural killer T cells (iNKT cells) are involved in the host defense against microbial infection. Although it is known that iNKT cells recognize…”
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CD169+ MACROPHAGES PRESENT LIPID ANTIGENS TO MEDIATE EARLY ACTIVATION OF INVARIANT NKT CELLS IN LYMPH NODES by Barral, Patricia, Polzella, Paolo, Bruckbauer, Andreas, van Rooijen, Nico, Besra, Gurdyal S., Cerundolo, Vincenzo, Batista, Facundo D.

“…Invariant NKT ( i NKT) cells are involved in host defence against microbial infections. While it is known that i NKT cells recognize glycolipids presented by…”
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