Search Results - "Polytarchou, Christos"

An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state by Polytarchou, Christos, Iliopoulos, Dimitrios, Struhl, Kevin

“…Cancer stem-like cells (CSCs) are a highly tumorigenic cell type present as a minority population in developmentally diverse tumors and cell lines. Using a…”
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Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms by Piskounova, Elena, Polytarchou, Christos, Thornton, James E., LaPierre, Robert J., Pothoulakis, Charalabos, Hagan, John P., Iliopoulos, Dimitrios, Gregory, Richard I.

“…Lin28A and Lin28B selectively block the expression of let-7 microRNAs and function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase…”
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Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells by Iliopoulos, Dimitrios, Lindahl-Allen, Marianne, Polytarchou, Christos, Hirsch, Heather A., Tsichlis, Philip N., Struhl, Kevin

“…In an inducible oncogenesis model, the miR-200 family is inhibited during CSC formation but not transformation, and inhibition of miR-200b increases CSC…”
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A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation by Padua, David, Mahurkar-Joshi, Swapna, Law, Ivy Ka Man, Polytarchou, Christos, Vu, John P, Pisegna, Joseph R, Shih, David, Iliopoulos, Dimitrios, Pothoulakis, Charalabos

“…High-throughput technologies revealed new categories of genes, including the long noncoding RNAs (lncRNAs), involved in the pathogenesis of human disease;…”
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MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis by Datta, Neha, Johnson, Charlotte, Kao, Dina, Gurnani, Pratik, Alexander, Cameron, Polytarchou, Christos, Monaghan, Tanya M.

“…An emerging but less explored shared pathophysiology across microbiota-gut-brain axis disorders is aberrant miRNA expression, which may represent novel…”
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Neurotensin Signaling Activates MicroRNAs-21 and -155 and Akt, Promotes Tumor Growth in Mice, and Is Increased in Human Colon Tumors by Bakirtzi, Kyriaki, Hatziapostolou, Maria, Karagiannides, Iordanes, Polytarchou, Christos, Jaeger, Savina, Iliopoulos, Dimitrios, Pothoulakis, Charalabos

“…Background & Aims Neurotensin promotes inflammation and colon cancer via the neurotensin-1 receptor (NTR1). MicroRNAs (miR) regulate protein synthesis by…”
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FGF-2 Regulates Cell Proliferation, Migration, and Angiogenesis through an NDY1/KDM2B-miR-101-EZH2 Pathway by Kottakis, Filippos, Polytarchou, Christos, Foltopoulou, Parthena, Sanidas, Ioannis, Kampranis, Sotirios C., Tsichlis, Philip N.

“…The histone H3K27 methyltransferase EZH2 plays an important role in oncogenesis, by mechanisms that are incompletely understood. Here, we show that the JmjC…”
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Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming by Koutsioumpa, Marina, Hatziapostolou, Maria, Polytarchou, Christos, Tolosa, Ezequiel J, Almada, Luciana L, Mahurkar-Joshi, Swapna, Williams, Jennifer, Tirado-Rodriguez, Ana Belen, Huerta-Yepez, Sara, Karavias, Dimitrios, Kourea, Helen, Poultsides, George A, Struhl, Kevin, Dawson, David W, Donahue, Timothy R, Fernández-Zapico, Martín E, Iliopoulos, Dimitrios

“…Despite advances in the identification of epigenetic alterations in pancreatic cancer, their biological roles in the pathobiology of this dismal neoplasm…”
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MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells by Iliopoulos, Dimitrios, Polytarchou, Christos, Hatziapostolou, Maria, Kottakis, Filippos, Maroulakou, Ioanna G, Struhl, Kevin, Tsichlis, Philip N

“…Although Akt is known to play a role in human cancer, the relative contribution of its three isoforms to oncogenesis remains to be determined. We expressed…”
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Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation by POLYTARCHOU, Christos, ILIOPOULOS, Dimitrios, HATZIAPOSTOLOU, Maria, KOTTAKIS, Filippos, MAROULAKOU, Ioanna, STRUHL, Kevin, TSICHLIS, Philip N

“…The growth and survival of tumor cells in an unfavorable hypoxic environment depend upon their adaptability. Here, we show that both normal and tumor cells…”
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Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway by Drakaki, Alexandra, Hatziapostolou, Maria, Polytarchou, Christos, Vorvis, Christina, Poultsides, George A, Souglakos, John, Georgoulias, Vassilis, Iliopoulos, Dimitrios

“…Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths, reflecting the aggressiveness of this type of cancer and the absence of…”
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Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer by Sanidas, Ioannis, Polytarchou, Christos, Hatziapostolou, Maria, Ezell, Scott A., Kottakis, Filippos, Hu, Lan, Guo, Ailan, Xie, Jianxin, Comb, Michael J., Iliopoulos, Dimitrios, Tsichlis, Philip N.

“…The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to…”
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The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression by Videlock, Elizabeth J, Shih, Wendy, Adeyemo, Mopelola, Mahurkar, Swapna, Presson, Angela P, Polytarchou, Christos, Alberto, Melissa, Iliopoulos, Dimitrios, Mayer, Emeran A, Chang, Lin

“…Highlights • Cortisol response to ACTH is affected by sex and irritable bowel syndrome (IBS). • Response is increased in men but blunted in women with IBS…”
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Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox by Polytarchou, Christos, Hatziapostolou, Maria, Yau, Tung On, Christodoulou, Niki, Hinds, Philip W., Kottakis, Filippos, Sanidas, Ioannis, Tsichlis, Philip N.

“…Akt activation up-regulates the intracellular levels of reactive oxygen species (ROS) by inhibiting ROS scavenging. Of the Akt isoforms, Akt3 has also been…”
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Hydrogen Peroxide Stimulates Proliferation and Migration of Human Prostate Cancer Cells through Activation of Activator Protein-1 and Up-regulation of the Heparin Affin Regulatory Peptide Gene by Polytarchou, Christos, Hatziapostolou, Maria, Papadimitriou, Evangelia

“…It is becoming increasingly recognized that hydrogen peroxide (HP) plays a role in cell proliferation and migration. In the present study we found that…”
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protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY by Ezell, Scott A, Polytarchou, Christos, Hatziapostolou, Maria, Guo, Ailan, Sanidas, Ioannis, Bihani, Teeru, Comb, Michael J, Sourvinos, George, Tsichlis, Philip N

“…The protein kinases Akt1, Akt2, and Akt3 possess nonredundant signaling properties, few of which have been investigated. Here, we present evidence for an…”
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Implications of differential transcription start site selection on chronic myeloid leukemia and prostate cancer cell protein expression by Surani, Arif A., Spriggs, Keith A., Ufer, Christoph, Polytarchou, Christos, Montiel-Duarte, Cristina

“…The relevance of minor transcription start sites in broad promoters is not well understood. We have studied AGAP2 expression in prostate cancer and chronic…”
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The JmjC Domain Histone Demethylase Ndy1 Regulates Redox Homeostasis and Protects Cells from Oxidative Stress by Polytarchou, Christos, Pfau, Raymond, Hatziapostolou, Maria, Tsichlis, Philip N.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Promoter Methylation Leads to Hepatocyte Nuclear Factor 4A Loss and Pancreatic Cancer Aggressiveness by Hatziapostolou, Maria, Koutsioumpa, Marina, Zaitoun, Abed M., Polytarchou, Christos, Edderkaoui, Mouad, Mahurkar-Joshi, Swapna, Vadakekolathu, Jayakumar, D'Andrea, Daniel, Lay, Anna Rose, Christodoulou, Niki, Pham, Thuy, Yau, Tung-On, Vorvis, Christina, Chatterji, Suchit, Pandol, Stephen J., Poultsides, George A., Dawson, David W., Lobo, Dileep N., Iliopoulos, Dimitrios

“…Decoding pancreatic ductal adenocarcinoma heterogeneity and the consequent therapeutic selection remains a challenge. We aimed to characterize epigenetically…”
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A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection by Monaghan, Tanya M, Duggal, Niharika A, Rosati, Elisa, Griffin, Ruth, Hughes, Jamie, Roach, Brandi, Yang, David Y, Wang, Christopher, Wong, Karen, Saxinger, Lynora, Pučić-Baković, Maja, Vučković, Frano, Klicek, Filip, Lauc, Gordan, Tighe, Paddy, Mullish, Benjamin H, Blanco, Jesus Miguens, McDonald, Julie A K, Marchesi, Julian R, Xue, Ning, Dottorini, Tania, Acharjee, Animesh, Franke, Andre, Li, Yingrui, Wong, Gane Ka-Shu, Polytarchou, Christos, Yau, Tung On, Christodoulou, Niki, Hatziapostolou, Maria, Wang, Minkun, Russell, Lindsey A, Kao, Dina H

“…Fecal microbiota transplantation (FMT) is highly effective in recurrent infection (CDI); increasing evidence supports FMT in severe or fulminant infection…”
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