Search Results - "Polo, Sophie E."

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA by Adam, Salomé, Polo, Sophie E., Almouzni, Geneviève

“…Understanding how to recover fully functional and transcriptionally active chromatin when its integrity has been challenged by genotoxic stress is a critical…”
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Prime, Repair, Restore: The Active Role of Chromatin in the DNA Damage Response by Soria, Gaston, Polo, Sophie E., Almouzni, Geneviève

“…The view of DNA packaging into chromatin as a mere obstacle to DNA repair is evolving. In this review, we focus on histone variants and heterochromatin…”
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Epigenome Maintenance in Response to DNA Damage by Dabin, Juliette, Fortuny, Anna, Polo, Sophie E.

“…Organism viability relies on the stable maintenance of specific chromatin landscapes, established during development, that shape cell functions and identities…”
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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications by Polo, Sophie E, Jackson, Stephen P

“…Genome integrity is constantly monitored by sophisticated cellular networks, collectively termed the DNA damage response (DDR). A common feature of DDR…”
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Chromatin dynamics after DNA damage: The legacy of the access–repair–restore model by Polo, Sophie E., Almouzni, Geneviève

“…•The ARR model integrates chromatin dynamics into the DNA damage response.•DNA damage-induced chromatin rearrangements prime chromatin for…”
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Reshaping Chromatin after DNA Damage: The Choreography of Histone Proteins by Polo, Sophie E.

“…DNA damage signaling and repair machineries operate in a nuclear environment where DNA is wrapped around histone proteins and packaged into chromatin…”
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The response to DNA damage in heterochromatin domains by Fortuny, Anna, Polo, Sophie E.

“…Eukaryotic genomes are organized into chromatin, divided into structurally and functionally distinct euchromatin and heterochromatin compartments. The high…”
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Imaging the response to DNA damage in heterochromatin domains reveals core principles of heterochromatin maintenance by Fortuny, Anna, Chansard, Audrey, Caron, Pierre, Chevallier, Odile, Leroy, Olivier, Renaud, Olivier, Polo, Sophie E.

“…Heterochromatin is a critical chromatin compartment, whose integrity governs genome stability and cell fate transitions. How heterochromatin features,…”
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Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining by Coates, Julia, Polo, Sophie E, Britton, Sébastien, Tjeertes, Jorrit V, Legube, Gaëlle, Jackson, Stephen P, Miller, Kyle M

“…How changes in chromatin can modulate the repair pathway of DNA double-strand breaks is now investigated. The work shows that histone deacetylases HDAC1 and…”
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Regulation of DNA-End Resection by hnRNPU-like Proteins Promotes DNA Double-Strand Break Signaling and Repair by Polo, Sophie E., Blackford, Andrew N., Chapman, J. Ross, Baskcomb, Linda, Gravel, Serge, Rusch, Andre, Thomas, Anoushka, Blundred, Rachel, Smith, Philippa, Kzhyshkowska, Julia, Dobner, Thomas, Taylor, A. Malcolm R., Turnell, Andrew S., Stewart, Grant S., Grand, Roger J., Jackson, Stephen P.

“…DNA double-strand break (DSB) signaling and repair are critical for cell viability, and rely on highly coordinated pathways whose molecular organization is…”
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DNA Double-Strand Break Repair: All Roads Lead to HeterochROMAtin Marks by Caron, Pierre, Pobega, Enrico, Polo, Sophie E.

“…In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA repair pathways thus safeguarding genome integrity. Recent studies have…”
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Replication stress induces 53BP1-containing OPT domains in G1 cells by Harrigan, Jeanine A, Belotserkovskaya, Rimma, Coates, Julia, Dimitrova, Daniela S, Polo, Sophie E, Bradshaw, Charles R, Fraser, Peter, Jackson, Stephen P

“…Chromosomal deletions and rearrangements in tumors are often associated with common fragile sites, which are specific genomic loci prone to gaps and breaks in…”
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Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage by Adam, Salomé, Dabin, Juliette, Chevallier, Odile, Leroy, Olivier, Baldeyron, Céline, Corpet, Armelle, Lomonte, Patrick, Renaud, Olivier, Almouzni, Geneviève, Polo, Sophie E.

“…Chromatin integrity is critical for cell function and identity but is challenged by DNA damage. To understand how chromatin architecture and the information…”
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Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1 by Ahel, Dragana, Hořejší, Zuzana, Wiechens, Nicola, Polo, Sophie E, Garcia-Wilson, Elisa, Ahel, Ivan, Flynn, Helen, Skehel, Mark, West, Stephen C, Jackson, Stephen P, Owen-Hughes, Tom, Boulton, Simon J

“…Posttranslational modifications play key roles in regulating chromatin plasticity. Although various chromatin-remodeling enzymes have been described that…”
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Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA by Bouvier, Déborah, Ferrand, Juliette, Chevallier, Odile, Paulsen, Michelle T., Ljungman, Mats, Polo, Sophie E.

“…Transcription restart after a genotoxic challenge is a fundamental yet poorly understood process. Here, we dissect the interplay between transcription and…”
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Histone Variants: Guardians of Genome Integrity by Ferrand, Juliette, Rondinelli, Beatrice, Polo, Sophie E

“…Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins,…”
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New Histone Incorporation Marks Sites of UV Repair in Human Cells by Polo, Sophie E., Roche, Danièle, Almouzni, Geneviève

“…Chromatin organization is compromised during the repair of DNA damage. It remains unknown how and to what extent epigenetic information is preserved in vivo. A…”
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Cornelia de Lange syndrome-associated mutations cause a DNA damage signalling and repair defect by Olley, Gabrielle, Pradeepa, Madapura M., Grimes, Graeme R., Piquet, Sandra, Polo, Sophie E., FitzPatrick, David R., Bickmore, Wendy A., Boumendil, Charlene

“…Cornelia de Lange syndrome is a multisystem developmental disorder typically caused by mutations in the gene encoding the cohesin loader NIPBL. The associated…”
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Chromatin plasticity in response to DNA damage: The shape of things to come by Adam, Salomé, Dabin, Juliette, Polo, Sophie E.

“…DNA damage poses a major threat to cell function and viability by compromising both genome and epigenome integrity. The DNA damage response indeed operates in…”
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Imaging the Response to DNA Damage in Heterochromatin Domains by Chansard, Audrey, Pobega, Enrico, Caron, Pierre, Polo, Sophie E.

“…The eukaryotic genome is assembled in a nucleoprotein complex called chromatin, whose organization markedly influences the repair of DNA lesions. For instance,…”
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