Search Results - "Polman, CH"

Differential diagnosis of suspected multiple sclerosis: a consensus approach by Miller, DH, Weinshenker, BG, Filippi, M, Banwell, BL, Cohen, JA, Freedman, MS, Galetta, SL, Hutchinson, M, Johnson, RT, Kappos, L, Kira, J, Lublin, FD, McFarland, HF, Montalban, X, Panitch, H, Richert, JR, Reingold, SC, Polman, CH

“…Background and objectives Diagnosis of multiple sclerosis (MS) requires exclusion of diseases that could better explain the clinical and paraclinical findings…”
Get full text

Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis by Van Boxel-Dezaire, A. H. H., Hoff, S. C. J., Van Oosten, B. W., Verweij, C. L., Dräger, A. M., Adèr, H. J., Van Houwelingen, J. C., Barkhof, F., Polman, C. H., Nagelkerken, L.

“…It has been shown that proinflammatory and antiinflammatory cytokines correlate with disease activity in multiple sclerosis (MS). To establish whether such…”
Get full text

Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration by Kearney, H, Rocca, MA, Valsasina, P, Balk, L, Sastre-Garriga, J, Reinhardt, J, Ruggieri, S, Rovira, A, Stippich, C, Kappos, L, Sprenger, T, Tortorella, P, Rovaris, M, Gasperini, C, Montalban, X, Geurts, JJG, Polman, CH, Barkhof, F, Filippi, M, Altmann, DR, Ciccarelli, O, Miller, DH, Chard, DT

“…Background: Understanding long-term disability in multiple sclerosis (MS) is a key goal of research; it is relevant to how we monitor and treat the disease…”
Get full text

Subcortical atrophy and cognition: Sex effects in multiple sclerosis by SCHOONHEIM, Menno M, POPESCU, Veronica, RUEDA LOPES, Fernanda C, WIEBENGA, Oliver T, VRENKEN, Hugo, DOUW, Linda, POLMAN, Chris H, GEURTS, Jeroen J. G, BARKHOF, Frederik

“…Gray matter (GM) atrophy is common in multiple sclerosis (MS), as is cognitive dysfunction. Understanding the exact relationship between atrophy and cognition…”
Get full text

Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes by KAPPOS, L, POLMAN, C. H, POHL, C, SANDBRINK, R, FREEDMAN, M. S, EDAN, G, HARTUNG, H. P, MILLER, D. H, MONTALBAN, X, BARKHOF, F, BAUER, L, JAKOBS, P

“…To assess efficacy, safety, and tolerability of every-other-day interferon beta-1b treatment in patients with a first clinical event suggestive of multiple…”
Get full text

Postmortem verification of MS cortical lesion detection with 3D DIR by SEEWANN, A, KOOI, E.-J, ROOSENDAAL, S. D, POUWELS, P. J. W, WATTJES, M. P, VAN DER VALK, P, BARKHOF, F, POLMAN, C. H, GEURTS, J. J. G

“…To assess the sensitivity and specificity of 3D double inversion recovery (DIR) MRI for detecting multiple sclerosis (MS) cortical lesions (CLs) using a direct…”
Get full text

EFNS guidelines on diagnosis and management of neuromyelitis optica by Sellner, J., Boggild, M., Clanet, M., Hintzen, R. Q., Illes, Z., Montalban, X., Du Pasquier, R. A., Polman, C. H., Sorensen, P. S., Hemmer, B.

“…Background and purpose:  Neuromyelitis optica (NMO) or Devic′s disease is a rare inflammatory and demyelinating autoimmune disorder of the central nervous…”
Get full text

Spinal cord lesions in patients with clinically isolated syndrome: A powerful tool in diagnosis and prognosis by SOMBEKKE, Madeleine H, WATTJES, Mike P, BALK, Lisanne J, NIELSEN, Jessica M, VRENKEN, Hugo, UITDEHAAG, Bernard M. J, POLMAN, Chris H, BARKHOF, Frederik

“…Spinal cord (SC) lesions are frequently found in multiple sclerosis (MS), but are rare in healthy aging and cerebrovascular patients. Our aim was to analyze…”
Get full text

A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis by Polman, Chris H, O'Connor, Paul W, Havrdova, Eva, Hutchinson, Michael, Kappos, Ludwig, Miller, David H, Phillips, J. Theodore, Lublin, Fred D, Giovannoni, Gavin, Wajgt, Andrzej, Toal, Martin, Lynn, Frances, Panzara, Michael A, Sandrock, Alfred W

“…This placebo-controlled, randomized trial of patients with relapsing multiple sclerosis demonstrated benefits of natalizumab (an α 4 integrin antagonist) in…”
Get full text

Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria" by Polman, Chris H., Reingold, Stephen C., Edan, Gilles, Filippi, Massimo, Hartung, Hans-Peter, Kappos, Ludwig, Lublin, Fred D., Metz, Luanne M., McFarland, Henry F., O'Connor, Paul W., Sandberg-Wollheim, Magnhild, Thompson, Alan J., Weinshenker, Brian G., Wolinsky, Jerry S.

“…New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in…”
Get full text

Structural degree predicts functional network connectivity: A multimodal resting-state fMRI and MEG study by Tewarie, P., Hillebrand, A., van Dellen, E., Schoonheim, M.M., Barkhof, F., Polman, C.H., Beaulieu, C., Gong, G., van Dijk, B.W., Stam, C.J.

“…Communication between neuronal populations in the human brain is characterized by complex functional interactions across time and space. Recent studies have…”
Get full text

Functional brain network analysis using minimum spanning trees in Multiple Sclerosis: An MEG source-space study by Tewarie, P., Hillebrand, A., Schoonheim, M.M., van Dijk, B.W., Geurts, J.J.G., Barkhof, F., Polman, C.H., Stam, C.J.

“…Cognitive dysfunction in Multiple Sclerosis (MS) is closely related to altered functional brain network topology. Conventional network analyses to compare…”
Get full text

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study by Kappos, Ludwig, Prof, Gold, Ralf, Prof, Miller, David H, Prof, MacManus, David G, MSc, Havrdova, Eva, MD, Limmroth, Volker, MD, Polman, Chris H, Prof, Schmierer, Klaus, PhD, Yousry, Tarek A, MD, Yang, Minhua, MS, Eraksoy, Mefkûre, Prof, Meluzinova, Eva, MD, Rektor, Ivan, MD, Dawson, Katherine T, MD, Sandrock, Alfred W, MD, O'Neill, Gilmore N, MB

“…Summary Background Oral fumarate (BG00012) might have dual anti-inflammatory and neuroprotective effects. Our aim was to assess the efficacy and safety of…”
Get full text

Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis by van de Kraats, C, Killestein, J, Popescu, V, Rijkers, E, Vrenken, H, Lütjohann, D, Barkhof, F, Polman, CH, Teunissen, CE

“…Background: Cholesterol homeostasis is important for formation and maintenance of myelin and axonal membranes in the central nervous system (CNS). The…”
Get full text

Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging by Geurts, Jeroen J G, Pouwels, Petra J W, Uitdehaag, Bernard M J, Polman, Chris H, Barkhof, Frederik, Castelijns, Jonas A

“…To prospectively compare the depiction of intracortical lesions by using multislab three-dimensional (3D) double inversion-recovery (DIR), multislab 3D…”
Get more information

Cortical Lesions in Multiple Sclerosis: Combined Postmortem MR Imaging and Histopathology by Geurts, Jeroen J. G, Bo, Lars, Pouwels, Petra J. W, Castelijns, Jonas A, Polman, Chris H, Barkhof, Frederik

“…Cortical lesions constitute a substantial part of the total lesion load in multiple sclerosis (MS) brain. They have been related to neuropsychological…”
Get full text

Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women by Kragt, JJ, van Amerongen, BM, Killestein, J, Dijkstra, CD, Uitdehaag, BMJ, Polman, CH, Lips, P

“…Introduction Multiple sclerosis (MS) is a chronic inflammatory disease with an as yet not fully understood etiological background. The geographical…”
Get full text

MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS by MILLER, D. H, SOON, D, KAPPOS, L, HUTCHINSON, M, HAVRDOVA, E, LUBLIN, F. D, GIOVANNONI, G, WAJGT, A, RUDICK, R, LYNN, F, PANZARA, M. A, SANDROCK, A. W, FERNANDO, K. T, MACMANUS, D. G, BARKER, G. J, YOUSRY, T. A, FISHER, E, O'CONNOR, P. W, PHILLIPS, J. T, POLMAN, C. H

“…In a 2-year, placebo-controlled trial (the Natalizumab Safety and Efficacy in Relapsing Remitting Multiple Sclerosis [AFFIRM] study), involving 942 patients…”
Get full text

Lack of Association between Antimyelin Antibodies and Progression to Multiple Sclerosis by Kuhle, Jens, Pohl, Christoph, Mehling, Matthias, Edan, Gilles, Freedman, Mark S, Hartung, Hans-Peter, Polman, Chris H, Miller, David H, Montalban, Xavier, Barkhof, Frederik, Bauer, Lars, Dahms, Susanne, Lindberg, Raija, Kappos, Ludwig, Sandbrink, Rupert

“…A previous study reported in the Journal showed an association between serum antimyelin antibodies (detected by Western blot analysis) and an increased risk of…”
Get full text

Disease course heterogeneity and OCT in multiple sclerosis by Balk, LJ, Tewarie, P, Killestein, J, Polman, CH, Uitdehaag, BMJ, Petzold, A

“…Background: The heterogeneity of the disease course in multiple sclerosis (MS) remains a challenge for patient management and clinical trials. Objective: The…”
Get full text