Search Results - "Pollock, John A"

Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation by Deal, Brooke, Reynolds, Laura M., Patterson, Charles, Janjic, Jelena M., Pollock, John A.

“…Neuropathic pain affects millions of people worldwide, yet the molecular mechanisms of how it develops and persists are poorly understood. Given that males…”
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Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat by Janjic, Jelena M., Vasudeva, Kiran, Saleem, Muzamil, Stevens, Andrea, Liu, Lu, Patel, Sravan, Pollock, John A.

“…Neuroinflammation involving macrophages elevates Prostaglandin E2, associated with neuropathic pain. Treatment with non-steroidal anti-inflammatory drugs…”
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RNA-Seq Reveals Sex Differences in Gene Expression during Peripheral Neuropathic Inflammation and in Pain Relief from a COX-2 Inhibiting Theranostic Nanoemulsion by Deal, Brooke, Phillips, Katherine, Crelli, Caitlin, Janjic, Jelena M, Pollock, John A

“…Given decades of neuroinflammatory pain research focused only on males, there is an urgent need to better understand neuroinflammatory pain in females. This,…”
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Folate-conjugated near-infrared fluorescent perfluorocarbon nanoemulsions as theranostics for activated macrophage COX-2 inhibition by Vichare, Riddhi, Crelli, Caitlin, Liu, Lu, McCallin, Rebecca, Cowan, Abree, Stratimirovic, Stefan, Herneisey, Michele, Pollock, John A., Janjic, Jelena M.

“…Activated macrophages play a critical role in the orchestration of inflammation and inflammatory pain in several chronic diseases. We present here the first…”
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Differential Expression of Neuroinflammatory mRNAs in the Rat Sciatic Nerve Following Chronic Constriction Injury and Pain-Relieving Nanoemulsion NSAID Delivery to Infiltrating Macrophages by Stevens, Andrea M, Liu, Lu, Bertovich, Dylan, Janjic, Jelena M, Pollock, John A

“…The neuroinflammatory response to peripheral nerve injury is associated with chronic pain and significant changes in the molecular expression profiles of mRNAs…”
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Cyclooxgenase-2 inhibiting perfluoropoly (ethylene glycol) ether theranostic nanoemulsions-in vitro study by Patel, Sravan Kumar, Zhang, Yang, Pollock, John A, Janjic, Jelena M

“…Cylcooxgenase-2 (COX-2) expressing macrophages, constituting a major portion of tumor mass, are involved in several pro-tumorigenic mechanisms. In addition,…”
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Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polarity and mast cell activation by Saleem, Muzamil, Deal, Brooke, Nehl, Emily, Janjic, Jelena M, Pollock, John A

“…We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve, by using a…”
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Two-color fluorescent (near-infrared and visible) triphasic perfluorocarbon nanoemulsions by Patel, Sravan Kumar, Patrick, Michael J, Pollock, John A, Janjic, Jelena M

“…Design and development of a new formulation as a unique assembly of distinct fluorescent reporters with nonoverlapping fluorescence spectra and a F19 magnetic…”
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Telling the Stories of Neuroscientific Discovery to Schoolchildren and the Public Can Make an Impact by Pollock, John A

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Imaging neuroinflammation in vivo in a neuropathic pain rat model with near-infrared fluorescence and ¹⁹F magnetic resonance by Vasudeva, Kiran, Andersen, Karl, Zeyzus-Johns, Bree, Hitchens, T Kevin, Patel, Sravan Kumar, Balducci, Anthony, Janjic, Jelena M, Pollock, John A

“…Chronic neuropathic pain following surgery represents a serious worldwide health problem leading to life-long treatment and the possibility of significant…”
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The acyltransferase Gpc1 is both a target and an effector of the unfolded protein response in Saccharomyces cerevisiae by Hrach, Victoria Lee, King, William R., Nelson, Laura D., Conklin, Shane, Pollock, John A., Patton-Vogt, Jana

“…The unfolded protein response (UPR) is sensitive to proteotoxic and membrane bilayer stress, both of which are sensed by the ER protein Ire1. When activated,…”
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Sex differences in behavior and immune response revealed by a NSAID nanotherapeutic treatment during peripheral neuroinflammation by Deal, Brooke S., Reynolds, Laura M., Janjic, Jelena M., Pollock, John A.

“…Until recently, the majority of preclinical neuroinflammatory studies were performed on males. Because of this, less is known about the female…”
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In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain by Vasudeva, Kiran, Vodovotz, Yoram, Azhar, Nabil, Barclay, Derek, Janjic, Jelena M, Pollock, John A

“…Abstract Inflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We…”
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Backward design as a mobile application development strategy by Kantorski, Brinley, Sanford-Dolly, Camellia W., Commisso, Danielle R., Pollock, John A.

“…Backward design is a well-established design strategy that has been used to produce educational curriculum for decades. While traditionally used to plan and…”
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Targeted cyclooxygenase-2 inhibiting nanomedicine results in pain-relief and differential expression of the RNA transcriptome in the dorsal root ganglia of injured male rats by Stevens, Andrea M, Saleem, Muzamil, Deal, Brooke, Janjic, Jelena, Pollock, John A

“…Chronic constriction injury of the sciatic nerve in rats causes peripheral neuropathy leading to pain-like behaviors commonly seen in humans. Neuropathy is a…”
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A New Best Practice for Validating Tail Vein Injections in Rat with Near-infrared-Labeled Agents by Saleem, Muzamil, Stevens, Andrea M, Deal, Brooke, Liu, Lu, Janjic, Jelena, Pollock, John A

“…Intravenous (IV) administration of agents into the tail vein of rats can be both difficult and inconsistent. Optimizing tail vein injections is a key part of…”
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Summer undergraduate research: A new pipeline for pain clinical practice and research by Kolber, Benedict J, Janjic, Jelena M, Pollock, John A, Tidgewell, Kevin J

“…Most medical schools fail to provide adequate training of clinicians in the treatment of pain. Similarly, despite the fact that over 1/3 of Americans suffer…”
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Ultrastructural Localization of Dendritic Messenger RNA in Adult Rat Hippocampus by Martone, Maryann E, Pollock, John A, Jones, Ying Zhang, Ellisman, Mark H

“…An ultrastructural examination of mRNA within adult rat CA1 hippocampal dendrites was conducted using two different methods. The messages for the alpha and…”
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Transcript localization of four opsin genes in the three visual organs of Drosophila; RH2 is ocellus specific by Pollock, J.A, Benzer, S

“…Drosophila and other Dipteran flies have three different kinds of visual organs; in the adult a pair of compound eyes and three dorsal ocelli; and in the larva…”
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Evaluating learning and attitudes on tissue engineering: a study of children viewing animated digital dome shows detailing the biomedicine of tissue engineering by Wilson, Anna C, Gonzalez, Laura L, Pollock, John A

“…Informal science education creates opportunities for the general public to learn about complex health and science topics. Tissue engineering is a fast-growing…”
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