Search Results - "Pollock, C A"

Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor by Saad, S., Stanners, S.R., Yong, R., Tang, O., Pollock, C.A.

“…Notch signalling pathway has been implicated as an important contributor to epithelial to myofibroblast transformation (EMT) in tumourigenesis. However, its…”
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Maternal L‐carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke by Saad, S, Al‐Odat, I, Chan, YL, McGrath, KC, Pollock, CA, Oliver, BG, Chen, H

“…Summary Sex differences in disease susceptibility due to maternal programming have been reported. We previously observed that maternal smoking induced renal…”
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Role of the EGF receptor in PPARγ-mediated sodium and water transport in human proximal tubule cells by Saad, S., Zhang, J., Yong, R., Yaghobian, D., Wong, M. G., Kelly, D. J., Chen, X. M., Pollock, C. A.

“…Aim/hypothesis This study aimed to determine the interaction between the EGF receptor (EGFR) and peroxisome proliferator-activated receptor γ (PPARγ) and the…”
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High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase by McGinn, S, Saad, S, Poronnik, P, Pollock, C A

“…The mitogen-activated protein (MAP) kinases contribute to altered cell growth and function in a variety of disease states. However, their role in the…”
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Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells by Qi, W., Chen, X., Twigg, S., Polhill, T.S., Gilbert, R.E., Pollock, C.A.

“…Tranilast (N-[3,4-dimethoxycinnamoyl]anthranilic acid) is a synthetic compound that we have recently reported to inhibit transforming growth factor-β1…”
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Intermittent high glucose enhances cell growth and collagen synthesis in cultured human tubulointerstitial cells by JONES, S. C, SAUNDERS, H. J, QI, W, POLLOCK, C. A

“…We investigated the effects of constant and intermittently increased glucose concentrations on human proximal tubule cells and cortical fibroblasts in primary…”
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Increased renal gene transcription of protein kinase C-β in human diabetic nephropathy: relationship to long-term glycaemic control by Langham, R. G, Kelly, D. J, Gow, R. M, Zhang, Y, Cox, A. J, Qi, W, Thai, K, Pollock, C. A, Christensen, P. K, Parving, H.-H, Gilbert, R. E

“…Aims/hypothesis Activation of protein kinase C (PKC) isoforms has been implicated as a central mediator in the pathogenesis of diabetic nephropathy. Although…”
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The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells by Panchapakesan, U, Pollock, C A, Chen, X M

“…Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) are ligand-activated transcription factors that regulate cell growth, inflammation, lipid…”
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Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure by Polhill, T S, Saad, S, Poronnik, P, Fulcher, G R, Pollock, C A

“…Postprandial hyperglycemia is implicated as a risk factor predisposing to vascular complications. This study was designed to assess recurrent short-term…”
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Paracrine stimulation of human renal fibroblasts by proximal tubule cells by JOHNSON, D. W, SAUNDERS, H. J, BAXTER, R. C, FIELD, M. J, POLLOCK, C. A

“…Paracrine stimulation of human renal fibroblasts by proximal tubule cells. Interstitial fibrosis strongly predicts the degree and progression of renal failure…”
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Effects of pathophysiological concentrations of albumin on NHE3 activity and cell proliferation in primary cultures of human proximal tubule cells by Lee, E M, Pollock, C A, Drumm, K, Barden, J A, Poronnik, P

“…The progression of renal disease correlates strongly with hypertension and the degree of proteinuria, suggesting a link between excessive Na+ reabsorption and…”
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Comparing different methods of assessing body composition in end-stage renal failure by Cooper, Bruce A., Aslani, Alireza, Ryan, Murielle, Zhu, Fiona Y-P, Ibels, Lloyd S., Allen, Barry J., Pollock, Carol A.

“…Comparing different methods of assessing body composition in end-stage renal failure. Accurate measurement of nutritional status in patients with end-stage…”
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The DPP-4 inhibitor linagliptin and the GLP-1 receptor agonist exendin-4 improve endothelium-dependent relaxation of rat mesenteric arteries in the presence of high glucose by Salheen, S.M., Panchapakesan, U., Pollock, C.A., Woodman, O.L.

“…The aim of the study was to investigate the effects of the DPP-4 inhibitors and GLP-1R agonist, exendin-4 on the mechanism(s) of endothelium-dependent…”
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KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis by Huang, Chunling, Shen, Sylvie, Ma, Qing, Gill, Anthony, Pollock, Carol A, Chen, Xin-Ming

“…Fibroblast activation plays a critical role in diabetic nephropathy (DN). The Ca2+-activated K+ channel KCa3.1 mediates cellular proliferation of many cell…”
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The effects of high glucose and atorvastatin on endothelial cell matrix production by McGinn, S., Poronnik, P., Gallery, E. D. M., Pollock, C. A.

“…Background  Statins are known to enhance atherosclerotic plaque stability through influences on extracellular matrix homeostasis. Net matrix production…”
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High glucose increases growth and collagen synthesis in cultured human tubulointerstitial cells by Jones, S. C., Saunders, H. J., Pollock, C. A.

“…Summary Aims Altered proximal tubular cell growth and interstitial fibrosis are features of diabetic nephropathy and correlate with disease progression. These…”
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Tubular sodium handling and tubuloglomerular feedback in experimental diabetes mellitus by Pollock, C A, Lawrence, J R, Field, M J

“…Tubular Na handling and tubuloglomerular feedback (TGF) activity were assessed using micropuncture techniques during the hyperfiltration phase of…”
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Renal expression of transforming growth factor-β inducible gene-h3 (βig-h3) in normal and diabetic rats by GILBERT, R. E, WILKINSON-BERKA, J. L, JOHNSON, D. W, COX, A, SOULIS, T, WU, L. L, KELLY, D. J, JERUMS, G, POLLOCK, C. A, COOPER, M. E

“…Transforming growth factor-beta (TGF-beta) has been implicated in the pathogenesis of a number of kidney diseases characterized by glomerulosclerosis and…”
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Effectiveness of Antiretroviral Therapy after Protease Inhibitor Failure: An Analytic Overview by Losina, Elena, Islam, Runa, Pollock, Alison C., Sax, Paul E., Freedberg, Kenneth A., Walensky, Rochelle P.

“…To examine effectiveness of subsequent antiretroviral therapy (ART), studies published during the period of 1 January 1997 through 31 May 2003 involving…”
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Protein intake in renal disease by POLLOCK, C. A, IBELS, L. S, ZHU, F.-Y, WARNANT, M, CATERSON, R. J, WAUGH, D. A, MAHONY, J. F

“…The dietary protein intake (DPI) of 766 patients (aged 7 to 88 yr) was determined from 24-h urinary urea and protein excretion by urea kinetic modelling. Five…”
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