Search Results - "Polling, Saskia"

Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation by Polling, Saskia, Ormsby, Angelique R, Wood, Rebecca J, Lee, Kristie, Shoubridge, Cheryl, Hughes, James N, Thomas, Paul Q, Griffin, Michael D W, Hill, Andrew F, Bowden, Quill, Böcking, Till, Hatters, Danny M

“…In vitro and in vivo analyses show that the aggregation mechanism of polyalanine expansions is based on assembly into α-helical clusters with diverse…”
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Tracking protein aggregation and mislocalization in cells with flow cytometry by Ramdzan, Yasmin M, Polling, Saskia, Chia, Cheryl P Z, Ng, Ivan H W, Ormsby, Angelique R, Croft, Nathan P, Purcell, Anthony W, Bogoyevitch, Marie A, Ng, Dominic C H, Gleeson, Paul A, Hatters, Danny M

“…Protein localization changes in cells are monitored at high-throughput applying pulse-shape analysis to flow-cytometry data. The authors use the technique in…”
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Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell by Polling, Saskia, Mok, Yee-Foong, Ramdzan, Yasmin M., Turner, Bradley J., Yerbury, Justin J., Hill, Andrew F., Hatters, Danny M.

“…Protein aggregation into intracellular inclusions is a key feature of many neurodegenerative disorders. A common theme has emerged that inappropriate…”
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Polyalanine expansions drive a shift into [alpha]-helical clusters without amyloid-fibril formation by Polling, Saskia, Ormsby, Angelique R, Wood, Rebecca J, Lee, Kristie, Shoubridge, Cheryl, Hughes, James N, Thomas, Paul Q, Griffin, Michael D W, Hill, Andrew F, Bowden, Quill, Böcking, Till, Hatters, Danny M

“…Polyglutamine (polyGln) expansions in nine human proteins result in neurological diseases and induce the proteins tendency to form b-rich amyloid fibrils and…”
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Submembranous recruitment of creatine kinase B supports formation of dynamic actin-based protrusions of macrophages and relies on its C-terminal flexible loop by Venter, Gerda, Polling, Saskia, Pluk, Helma, Venselaar, Hanka, Wijers, Mietske, Willemse, Marieke, Fransen, Jack A.M., Wieringa, Bé

“…Subcellular partitioning of creatine kinase contributes to the formation of patterns in intracellular ATP distribution and the fuelling of cellular processes…”
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Polyglutamine aggregation in Huntington and related diseases by Polling, Saskia, Hill, Andrew F, Hatters, Danny M

“…Polyglutamine (polyQ)-expansions in different proteins cause nine neurodegenerative diseases. While polyQ aggregation is a key pathological hallmark of these…”
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Size analysis of polyglutamine protein aggregates using fluorescence detection in an analytical ultracentrifuge by Polling, Saskia, Hatters, Danny M, Mok, Yee-Foong

“…Defining the aggregation process of proteins formed by poly-amino acid repeats in cells remains a challenging task due to a lack of robust techniques for their…”
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