Prevention of rat liver fibrosis and carcinogenesis by coffee and caffeine

•Conventional coffee or caffeine intake reduced the liver collagen content and collagen I mRNA levels.•Instant coffee or caffeine intake inhibited the development of hepatocellular pre-neoplastic and neoplastic lesions.•Coffee beverages are potential functional food against liver fibrosis and carcin...

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Published in:	Food and chemical toxicology Vol. 64; pp. 20 - 26
Main Authors:	Furtado, Kelly S., Polletini, Jossimara, Dias, Marcos C., Rodrigues, Maria A.M., Barbisan, Luis F.
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-02-2014 Elsevier
Subjects:	Animals Biological and medical sciences Blotting, Western Caffeine Caffeine - pharmacology Carcinogenesis - drug effects Carcinogenesis, carcinogens and anticarcinogens Chemical agents Coffee Coffee beverages Collagen - metabolism Glutathione Transferase - metabolism Liver Cirrhosis - prevention & control Liver fibrosis and carcinogenesis Liver Neoplasms, Experimental - enzymology Liver Neoplasms, Experimental - prevention & control Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Precancerous Conditions - enzymology Precancerous Conditions - metabolism Prevention Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Real-Time Polymerase Chain Reaction Toxicology Tumors Liver fibrosis and carcinogenesis Prevention Coffee beverages Caffeine Rat CNS stimulant Psychotropic Liver Rodentia Coffee Carcinogenesis Respiratory analeptic Vertebrata Mammalia Animal Fibrosis Xanthine derivatives Beverage
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Summary:	•Conventional coffee or caffeine intake reduced the liver collagen content and collagen I mRNA levels.•Instant coffee or caffeine intake inhibited the development of hepatocellular pre-neoplastic and neoplastic lesions.•Coffee beverages are potential functional food against liver fibrosis and carcinogenesis. Coffee has been inversely related to the incidence of human liver disease; however, whether caffeine is the component responsible for the beneficial effects of coffee remains controversial. This study evaluated the beneficial effects of coffee or caffeine in a medium-term bioassay for rat liver fibrosis/carcinogenesis induced by diethylnitrosamine (DEN) and carbon tetrachloride (CCl4). One week after the DEN injection, the groups started to receive conventional coffee, instant coffee or 0.1% caffeine ad libitum for 24weeks. The groups receiving conventional coffee or caffeine presented a significant reduction in collagen content and mRNA expression of collagen I. The groups receiving instant coffee or caffeine had a significant reduction in the size and area of pre-neoplastic lesions and in the mean number of neoplastic lesions. A significant increase in liver bax protein levels was observed in the groups receiving instant coffee or caffeine as compared to the control group. These data indicate that the most pronounced hepatoprotective effect against fibrosis was observed in the groups receiving conventional coffee and 0.1% caffeine, and the greatest effects against liver carcinogenesis were detected in the groups receiving instant coffee and 0.1% caffeine.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0278-6915 1873-6351
DOI:	10.1016/j.fct.2013.11.011