Search Results - "Poller, Birk"

Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data by Kunze, Annett, Huwyler, Jörg, Camenisch, Gian, Poller, Birk

“…Organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3 are drug transporters mediating the active hepatic uptake of their substrates. Because they…”
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A Systematic In Vitro Investigation of the Inhibitor Preincubation Effect on Multiple Classes of Clinically Relevant Transporters by Tátrai, Péter, Schweigler, Patrick, Poller, Birk, Domange, Norbert, de Wilde, Roelof, Hanna, Imad, Gáborik, Zsuzsanna, Huth, Felix

“…Preincubation of a drug transporter with its inhibitor in a cell-based assay may result in the apparent enhancement of the inhibitory potency. Currently,…”
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human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies by Poller, Birk, Gutmann, Heike, Krähenbühl, Stephan, Weksler, Babette, Romero, Ignacio, Couraud, Pierre-Olivier, Tuffin, Gerald, Drewe, Jürgen, Huwyler, Jörg

“…The human brain endothelial capillary cell line hCMEC/D3 has been developed recently as a model for the human blood-brain barrier. In this study a further…”
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The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development by Keuper-Navis, Marit, Walles, Markus, Poller, Birk, Myszczyszyn, Adam, van der Made, Thomas K., Donkers, Joanne, Eslami Amirabadi, Hossein, Wilmer, Martijn J., Aan, Saskia, Spee, Bart, Masereeuw, Rosalinde, van de Steeg, Evita

“…Organ-on-chip (OoC) technology has led to in vitro models with many new possibilities compared to conventional in vitro and in vivo models. In this review, the…”
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Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood-Brain Barrier by Poller, Birk, Drewe, Jürgen, Krähenbühl, Stephan, Huwyler, Jörg, Gutmann, Heike

“…Brain capillary endothelial cells form the blood-brain barrier (BBB), a highly selective permeability membrane between the blood and the brain. Besides tight…”
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In vitro-in vivo extrapolation method to predict human renal clearance of drugs by Kunze, Annett, Huwyler, Jörg, Poller, Birk, Gutmann, Heike, Camenisch, Gian

“…Renal clearance is a key determinant of the elimination of drugs. To date, only few in vitro-in vivo extrapolation (IVIVE) approaches have been described to…”
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New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data by Riede, Julia, Poller, Birk, Umehara, Ken-ichi, Huwyler, Jörg, Camenisch, Gian

“…Total human clearance is a key determinant for the pharmacokinetic behavior of drug candidates. Our group recently introduced the Extended Clearance Model…”
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Double-Transduced MDCKII Cells To Study Human P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Interplay in Drug Transport across the Blood−Brain Barrier by Poller, Birk, Wagenaar, Els, Tang, Seng Chuan, Schinkel, Alfred H

“…P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) combination knockout mice display disproportionately increased brain penetration…”
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Novel Bruton’s Tyrosine Kinase inhibitor remibrutinib: Drug‐drug interaction potential as a victim of CYP3A4 inhibitors based on clinical data and PBPK modeling by Huth, Felix, Schiller, Hilmar, Jin, Yi, Poller, Birk, Schuhler, Carole, Weis, Wendy, Woessner, Ralph, Drollmann, Anton, End, Peter

“…Remibrutinib, a novel oral Bruton’s Tyrosine Kinase inhibitor (BTKi) is highly selective for BTK, potentially mitigating the side effects of other BTKis…”
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LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial by Loesche, Christian, Picard, Damien, Van Hoorick, Benjamin, Schuhmann, Imelda, Jäger, Petra, Klein, Kai, Schuhler, Carole, Thoma, Gebhard, Markert, Christian, Poller, Birk, Zamurovic, Natasa, Weiss, H. Markus, Otto, Heike, Fink, Martin, Röhn, Till A.

“…LYS006 is a novel, highly potent and selective, new‐generation leukotriene A4 hydrolase (LTA4H) inhibitor in clinical development for the treatment of…”
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Differential Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on Axitinib Brain Accumulation and Oral Plasma Pharmacokinetics by POLLER, Birk, IUSUF, Dilek, SPARIDANS, Rolf W, WAGENAAR, Els, BEIJNEN, Jos H, SCHINKEL, Alfred H

“…The second-generation tyrosine kinase inhibitor and anticancer drug axitinib is a potent, orally active inhibitor of the vascular endothelial growth factor…”
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Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3 by Fasler-Kan, Elizaveta, Suenderhauf, Claudia, Barteneva, Natasha, Poller, Birk, Gygax, Daniel, Huwyler, Jörg

“…Abstract Brain microvascular endothelial cells are part of the blood–brain barrier and participate actively in immunological processes including…”
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Simplifying the Extended Clearance Concept Classification System (EC3S) to Guide Clearance Prediction in Drug Discovery by Patel, Mitesh, Riede, Julia, Bednarczyk, Dallas, Poller, Birk, Deshmukh, Sujal V.

“…Purpose The Extended Clearance Concept Classification System was established as a development-stage tool to provide a framework for identifying fundamental…”
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Improving In Vitro-In Vivo Extrapolation (IVIVE) of Clearance Using Rat Liver Microsomes for Highly Plasma Protein Bound Molecules by Trunzer, Markus, Teigão, Joana, Huth, Felix, Poller, Birk, Desrayaud, Sandrine, Rodríguez-Pérez, Raquel, Faller, Bernard

“…It is common practice in drug discovery and development to predict in vivo hepatic clearance from in vitro incubations with liver microsomes or hepatocytes…”
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Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations by Riede, Julia, Poller, Birk, Huwyler, Jörg, Camenisch, Gian

“…Inhibition of the bile salt export pump (BSEP) has been recognized as a key factor in the development of drug-induced cholestasis (DIC). The risk of DIC in…”
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Clinical Investigation of Metabolic and Renal Clearance Pathways Contributing to the Elimination of Fevipiprant Using Probenecid as Perpetrator by Weiss, H Markus, Langenickel, Thomas, Cain, Meredith, Kulkarni, Swarupa, Shah, Bharti, Vemula, Janardhana, Rahmanzadeh, Gholamreza, Poller, Birk

“…Fevipiprant, an oral, nonsteroidal, highly selective, reversible, and competitive prostaglandin D receptor 2 antagonist, is eliminated by glucuronidation and…”
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Drug-induced cholestasis (DIC) predictions based on in vitro inhibition of major bile acid clearance mechanisms by Kastrinou-Lampou, Vlasia, Rodríguez-Pérez, Raquel, Poller, Birk, Huth, Felix, Schadt, Heiko S., Kullak-Ublick, Gerd A., Arand, Michael, Camenisch, Gian

“…Drug-induced cholestasis (DIC) is recognized as a major safety concern in drug development, as it represents one of the three types of drug-induced liver…”
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Absorption, Distribution, Metabolism, and Excretion of [ 14 C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro Studies by James, Alexander David, Kulmatycki, Kenneth, Poller, Birk, Romeo, Andrea A, Van Lier, Jan Jaap, Klein, Kai, Pearson, David

“…Iptacopan (LNP023) is an oral, small-molecule, first-in-class, highly potent proximal complement inhibitor that specifically binds factor B and inhibits the…”
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The extended clearance model and its use for the interpretation of hepatobiliary elimination data by Camenisch, Gian, Riede, Julia, Kunze, Annett, Huwyler, Jörg, Poller, Birk, Umehara, Kenichi

“…Hepatic elimination is a function of the interplay between different processes such as sinusoidal uptake, intracellular metabolism, canalicular (biliary)…”
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Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes by Kastrinou Lampou, Vlasia, Poller, Birk, Huth, Felix, Fischer, Audrey, Kullak-Ublick, Gerd A., Arand, Michael, Schadt, Heiko S., Camenisch, Gian

“…Bile acid (BA) homeostasis is a complex and precisely regulated process to prevent impaired BA flow and the development of cholestasis. Several reactions,…”
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