Search Results - "Pollard, Steven M."

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion by Gangoso, Ester, Southgate, Benjamin, Bradley, Leanne, Rus, Stefanie, Galvez-Cancino, Felipe, McGivern, Niamh, Güç, Esra, Kapourani, Chantriolnt-Andreas, Byron, Adam, Ferguson, Kirsty M., Alfazema, Neza, Morrison, Gillian, Grant, Vivien, Blin, Carla, Sou, IengFong, Marques-Torrejon, Maria Angeles, Conde, Lucia, Parrinello, Simona, Herrero, Javier, Beck, Stephan, Brandner, Sebastian, Brennan, Paul M., Bertone, Paul, Pollard, Jeffrey W., Quezada, Sergio A., Sproul, Duncan, Frame, Margaret C., Serrels, Alan, Pollard, Steven M.

“…Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms…”
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Post-translational modification of SOX family proteins: Key biochemical targets in cancer? by Williams, Charles A.C., Soufi, Abdenour, Pollard, Steven M.

“…Sox proteins are a family of lineage-associated transcription factors. They regulate expression of genes involved in control of self-renewal and multipotency…”
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Cohesin-mediated interactions organize chromosomal domain architecture by Sofueva, Sevil, Yaffe, Eitan, Chan, Wen-Ching, Georgopoulou, Dimitra, Vietri Rudan, Matteo, Mira-Bontenbal, Hegias, Pollard, Steven M, Schroth, Gary P, Tanay, Amos, Hadjur, Suzana

“…To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other…”
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Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators by Bulstrode, Harry, Johnstone, Ewan, Marques-Torrejon, Maria Angeles, Ferguson, Kirsty M, Bressan, Raul Bardini, Blin, Carla, Grant, Vivien, Gogolok, Sabine, Gangoso, Ester, Gagrica, Sladjana, Ender, Christine, Fotaki, Vassiliki, Sproul, Duncan, Bertone, Paul, Pollard, Steven M

“…Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks of neural stem (NS) cells. GBM stem cells frequently express high…”
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The white matter is a pro-differentiative niche for glioblastoma by Brooks, Lucy J., Clements, Melanie P., Burden, Jemima J., Kocher, Daniela, Richards, Luca, Devesa, Sara Castro, Zakka, Leila, Woodberry, Megan, Ellis, Michael, Jaunmuktane, Zane, Brandner, Sebastian, Morrison, Gillian, Pollard, Steven M., Dirks, Peter B., Marguerat, Samuel, Parrinello, Simona

“…Glioblastomas are hierarchically organised tumours driven by glioma stem cells that retain partial differentiation potential. Glioma stem cells are maintained…”
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LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells by Marqués-Torrejón, María Ángeles, Williams, Charles A. C., Southgate, Benjamin, Alfazema, Neza, Clements, Melanie P., Garcia-Diaz, Claudia, Blin, Carla, Arranz-Emparan, Nerea, Fraser, Jane, Gammoh, Noor, Parrinello, Simona, Pollard, Steven M.

“…Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single-cell analysis has suggested a continuum of cell states as NSCs exit…”
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Experimental models and tools to tackle glioblastoma by Robertson, Faye L, Marqués-Torrejón, Maria-Angeles, Morrison, Gillian M, Pollard, Steven M

“…Glioblastoma multiforme (GBM) is one of the deadliest human cancers. Despite increasing knowledge of the genetic and epigenetic changes that underlie tumour…”
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Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells by Brien, Gerard L., Bressan, Raul Bardini, Monger, Craig, Gannon, Dáire, Lagan, Eimear, Doherty, Anthony M., Healy, Evan, Neikes, Hannah, Fitzpatrick, Darren J., Deevy, Orla, Grant, Vivien, Marqués-Torrejón, Maria-Angeles, Alfazema, Neza, Pollard, Steven M., Bracken, Adrian P.

“…Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However,…”
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Engineering Cancer Selective Virotherapies: Are the Pieces of the Puzzle Falling into Place? by Swift, Emma A, Pollard, Steven M, Parker, Alan L

“…Advances in gene therapy, synthetic biology, cancer genomics, and patient-derived cancer models have expanded the repertoire of strategies for targeting human…”
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Modelling glioblastoma tumour-host cell interactions using adult brain organotypic slice co-culture by Marques-Torrejon, Maria Angeles, Gangoso, Ester, Pollard, Steven M

“…Glioblastoma multiforme (GBM) is an aggressive incurable brain cancer. The cells that fuel the growth of tumours resemble neural stem cells found in the…”
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Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation by Badodi, Sara, Pomella, Nicola, Zhang, Xinyu, Rosser, Gabriel, Whittingham, John, Niklison-Chirou, Maria Victoria, Lim, Yau Mun, Brandner, Sebastian, Morrison, Gillian, Pollard, Steven M., Bennett, Christopher D., Clifford, Steven C., Peet, Andrew, Basson, M. Albert, Marino, Silvia

“…Deregulation of chromatin modifiers plays an essential role in the pathogenesis of medulloblastoma, the most common paediatric malignant brain tumour. Here, we…”
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Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest by Carén, Helena, Stricker, Stefan H., Bulstrode, Harry, Gagrica, Sladjana, Johnstone, Ewan, Bartlett, Thomas E., Feber, Andrew, Wilson, Gareth, Teschendorff, Andrew E., Bertone, Paul, Beck, Stephan, Pollard, Steven M.

“…Glioblastoma (GBM) is an aggressive brain tumor whose growth is driven by stem cell-like cells. BMP signaling triggers cell-cycle exit and differentiation of…”
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Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner by Stricker, Stefan H, Feber, Andrew, Engström, Pär G, Carén, Helena, Kurian, Kathreena M, Takashima, Yasuhiro, Watts, Colin, Way, Michael, Dirks, Peter, Bertone, Paul, Smith, Austin, Beck, Stephan, Pollard, Steven M

“…Epigenetic changes are frequently observed in cancer. However, their role in establishing or sustaining the malignant state has been difficult to determine due…”
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Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells by Bulstrode, Harry, Girdler, Gemma C., Gracia, Tannia, Aivazidis, Alexander, Moutsopoulos, Ilias, Young, Adam M.H., Hancock, John, He, Xiaoling, Ridley, Katherine, Xu, Zhaoyang, Stockley, John H., Finlay, John, Hallou, Clement, Fajardo, Teodoro, Fountain, Daniel M., van Dongen, Stijn, Joannides, Alexis, Morris, Robert, Mair, Richard, Watts, Colin, Santarius, Thomas, Price, Stephen J., Hutchinson, Peter J.A., Hodson, Emma J., Pollard, Steven M., Mohorianu, Irina, Barker, Roger A., Sweeney, Trevor R., Bayraktar, Omer, Gergely, Fanni, Rowitch, David H.

“…Zika virus (ZIKV) can infect human developing brain (HDB) progenitors resulting in epidemic microcephaly, whereas analogous cellular tropism offers treatment…”
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Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma by O’Connor, Samantha A, Feldman, Heather M, Arora, Sonali, Hoellerbauer, Pia, Toledo, Chad M, Corrin, Philip, Carter, Lucas, Kufeld, Megan, Bolouri, Hamid, Basom, Ryan, Delrow, Jeffrey, McFaline‐Figueroa, José L, Trapnell, Cole, Pollard, Steven M, Patel, Anoop, Paddison, Patrick J, Plaisier, Christopher L

“…Single‐cell RNA sequencing has emerged as a powerful tool for resolving cellular states associated with normal and maligned developmental processes. Here, we…”
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TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers by Damhofer, Helene, Tatar, Tülin, Southgate, Benjamin, Scarneo, Scott, Agger, Karl, Shlyueva, Daria, Uhrbom, Lene, Morrison, Gillian M., Hughes, Philip F., Haystead, Timothy, Pollard, Steven M., Helin, Kristian

“…Poor survival and lack of treatment response in glioblastoma (GBM) is attributed to the persistence of glioma stem cells (GSCs). To identify novel therapeutic…”
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Niche-independent symmetrical self-renewal of a mammalian tissue stem cell by Conti, Luciano, Pollard, Steven M, Gorba, Thorsten, Reitano, Erika, Toselli, Mauro, Biella, Gerardo, Sun, Yirui, Sanzone, Sveva, Ying, Qi-Long, Cattaneo, Elena, Smith, Austin

“…Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to…”
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STAR: a simple TAL effector assembly reaction using isothermal assembly by Gogolok, Sabine, Garcia-Diaz, Claudia, Pollard, Steven M.

“…Transcription activator-like effectors (TALEs) contain modular programmable DNA binding domains. Fusing TALEs with effector domains creates synthetic…”
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Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A by Hubert, Christopher G, Bradley, Robert K, Ding, Yu, Toledo, Chad M, Herman, Jacob, Skutt-Kakaria, Kyobi, Girard, Emily J, Davison, Jerry, Berndt, Jason, Corrin, Philip, Hardcastle, Justin, Basom, Ryan, Delrow, Jeffery J, Webb, Thomas, Pollard, Steven M, Lee, Jeongwu, Olson, James M, Paddison, Patrick J

“…To identify key regulators of human brain tumor maintenance and initiation, we performed multiple genome-wide RNAi screens in patient-derived glioblastoma…”
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EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells by Krusche, Benjamin, Ottone, Cristina, Clements, Melanie P, Johnstone, Ewan R, Goetsch, Katrin, Lieven, Huang, Mota, Silvia G, Singh, Poonam, Khadayate, Sanjay, Ashraf, Azhaar, Davies, Timothy, Pollard, Steven M, De Paola, Vincenzo, Roncaroli, Federico, Martinez-Torrecuadrada, Jorge, Bertone, Paul, Parrinello, Simona

“…Glioblastomas (GBM) are aggressive and therapy-resistant brain tumours, which contain a subpopulation of tumour-propagating glioblastoma stem-like cells (GSC)…”
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