Search Results - "Pollard, H B"

Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients by Yang, Q, Soltis, A R, Sukumar, G, Zhang, X, Caohuy, H, Freedy, J, Dalgard, C L, Wilkerson, M D, Pollard, H B, Pollard, B S

“…Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease,…”
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Identifying conservation successes, failures and future opportunities; assessing recovery potential of wild ungulates and tigers in Eastern Cambodia by O'Kelly, Hannah J, Evans, Tom D, Stokes, Emma J, Clements, Tom J, Dara, An, Gately, Mark, Menghor, Nut, Pollard, Edward H B, Soriyun, Men, Walston, Joe

“…Conservation investment, particularly for charismatic and wide-ranging large mammal species, needs to be evidence-based. Despite the prevalence of this theme…”
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The MCP-4/MCP-1 ratio in plasma is a candidate circadian biomarker for chronic post-traumatic stress disorder by Dalgard, C, Eidelman, O, Jozwik, C, Olsen, C H, Srivastava, M, Biswas, R, Eudy, Y, Rothwell, S W, Mueller, G P, Yuan, P, Drevets, W C, Manji, H K, Vythlingam, M, Charney, D S, Neumeister, A, Ursano, R J, Jacobowitz, D M, Pollard, H B, Bonne, O

“…Post-traumatic stress disorder (PTSD) is psychiatric disease, which can occur following exposure to traumatic events. PTSD may be acute or chronic, and can…”
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Alzheimer Disease Amyloid β Protein Forms Calcium Channels in Bilayer Membranes: Blockade by Tromethamine and Aluminum by Arispe, Nelson, Rojas, Eduardo, Pollard, Harvey B.

“…Amyloid β protein (AβP) is the 40- to 42-residue polypeptide implicated in the pathogenesis of Alzheimer disease. We have incorporated this peptide into…”
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Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells by Torosyan, Y, Dobi, A, Glasman, M, Mezhevaya, K, Naga, S, Huang, W, Paweletz, C, Leighton, X, Pollard, H B, Srivastava, M

“…Annexin-A7 (ANXA7) tumor suppressor role has been shown in various tumors, and ANXA7 expression has been particularly lost in androgen-resistant prostate…”
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Giant Multilevel Cation Channels Formed by Alzheimer Disease Amyloid β-Protein [AβP-(1-40)] in Bilayer Membranes by Arispe, Nelson, Pollard, Harvey B., Rojas, Eduardo

“…We have recently shown that the Alzheimer disease 40-residue amyloid β-protein [Aβ P-(1-40)] can form cation-selective channels when incorporated into planar…”
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miR-16 rescues F508del-CFTR function in native cystic fibrosis epithelial cells by Kumar, P, Bhattacharyya, S, Peters, K W, Glover, M L, Sen, A, Cox, R T, Kundu, S, Caohuy, H, Frizzell, R A, Pollard, H B, Biswas, R

“…Cystic fibrosis (CF) is due to mutations in the CFTR gene, which prevents correct folding, trafficking and function of the mutant cystic fibrosis transmembrane…”
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Zn2+Interaction with Alzheimer Amyloid β Protein Calcium Channels by Arispe, Nelson, Pollard, Harvey B., Rojas, Eduardo

“…The Alzheimer disease 40-residue amyloid β protein (Aβ P[1-40]) forms cation-selective channels across acidic phospholipid bilayer membranes with spontaneous…”
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Pharmacogenomics of the cystic fibrosis transmembrane conductance regulator (CFTR) and the cystic fibrosis drug CPX using genome microarray analysis by Srivastava, M, Eidelman, O, Pollard, H B

“…Cystic fibrosis (CF) is the most common lethal recessive disease affecting children in the U.S. and Europe. For this reason, a number of ongoing attempts are…”
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Calcium-activated endonexin II forms calcium channels across acidic phospholipid bilayer membranes by Rojas, E, Pollard, H B, Haigler, H T, Parra, C, Burns, A L

“…Human endonexin II (annexin V) and recombinant human endonexin II can be activated by Ca2+ to interact with acidic phospholipid bilayers formed at the tip of a…”
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Membrane fusion protein synexin (annexin VII) as a Ca2+/GTP sensor in exocytotic secretion by Caohuy, H, Srivastava, M, Pollard, H B

“…Exocytotic membrane fusion and secretion are promoted by the concerted action of GTP and Ca2+, although the precise site(s) of action in the process are not…”
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Annexin 7 mobilizes calcium from endoplasmic reticulum stores in brain by Watson, W.D., Srivastava, M., Leighton, X., Glasman, M., Faraday, M., Fossam, L.H., Pollard, H.B., Verma, A.

“…Mobilization of intracellular calcium from inositol-1,4,5-triphosphate (IP3)-sensitive endoplasmic reticulum (ER) stores plays a prominent role in brain…”
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Theoretical models of the ion channel structure of amyloid beta-protein by Durell, S.R., Guy, H.R., Arispe, N., Rojas, E., Pollard, H.B.

“…Theoretical methods are used to develop models for the ion channel structure of the membrane-bound amyloid beta-protein. This follows recent observations that…”
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Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells by Raviv, Y, Pollard, H B, Bruggemann, E P, Pastan, I, Gottesman, M M

“…A 170,000-Da glycoprotein (P170 multidrug transporter) becomes specifically labeled in multidrug-resistant human KB carcinoma cells by the photolabile…”
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Annexin 7: A Non-SNARE Proteolytic Substrate for Botulinum Toxin Type C in Secreting Chromaffin Cells by CAOHUY, H., POLLARD, H. B.

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A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells by EIDELMAN, O, GUAY-BRODER, C, VAN GALEN, P. J. M, JACOBSON, K. A, FOX, C, TURNER, R. J, CABANTICHIK, Z. I, POLLARD, H. B

“…A1 adenosine-receptor-antagonist drugs such as 8-cyclopentyl-1,3-dipropylxanthine (CPX) and xanthine amine congener (XAC) are found to activate the efflux of…”
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Molecular dissection of nucleolin's role in growth and cell proliferation: new insights by Srivastava, Meera, Pollard, Harvey B.

“…ABSTRACTCells require optimum protein synthetic activity in order to support cell proliferation, maintain homeostatic and metabolic integrity, and repair…”
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Adenosine Triphosphate Stimulates Inositol Phospholipid Metabolism and Prostacyclin Formation in Adrenal Medullary Endothelial Cells by means of P2-purinergic Receptors by Forsberg, Erik J., Feuerstein, Giora, Shohami, Esther, Pollard, Harvey B.

“…In the adrenal medulla, chromaffin cells secrete high concentrations of catecholamines, ATP, peptides and other factors that must pass through an endothelial…”
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Calcium Channel Activity of Purified Human Synexin and Structure of the Human Synexin Gene by Burns, A. Lee, Magendzo, Karin, Shirvan, Anat, Srivastava, Meera, Rojas, Eduardo, Alijani, Mohammed R., Pollard, Harvey B.

“…Synexin is a calcium-dependent membrane binding protein that not only fuses membranes but also acts as a voltage-dependent calcium channel. We have isolated…”
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8-Cyclopentyl-1,3-dipropylxanthine and Other Xanthines Differentially Bind to the Wild-Type and ΔF508 Mutant First Nucleotide Binding Fold (NBF-1) Domains of the Cystic Fibrosis Transmembrane Conductance Regulator by Cohen, B. E, Lee, G, Jacobson, K. A, Kim, Y.-C, Huang, Z, Sorscher, E. J, Pollard, H. B

“…Cystic fibrosis is an autosomal recessive disorder affecting chloride transport in pancreas, lung, and other tissues, which is caused by mutations in the…”
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