Search Results - "Pollakis, Georgios"

Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection by Clarke, Jenny, Baltazar, Murielle, Alsahag, Mansoor, Panagiotou, Stavros, Pouget, Marion, Paxton, William A., Pollakis, Georgios, Everett, Dean, French, Neil, Kadioglu, Aras

“…Group A Streptoccocus (GAS) is among the most diverse of all human pathogens, responsible for a range of clinical manifestations, from mild superficial…”
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Measuring the Success of HIV-1 Cure Strategies by Thomas, Jordan, Ruggiero, Alessandra, Paxton, William A, Pollakis, Georgios

“…HIV-1 eradication strategies aim to achieve viral remission in the absence of antiretroviral therapy (ART). The development of an HIV-1 cure remains…”
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Development of a pseudo-typed virus particle based method to determine the efficacy of virucidal agents by Thomas, Jordan, Mughal, Farah, Roper, Kelly J., Kotsiri, Aurelia, Albalawi, Wejdan, Alshehri, Abdullateef, Reddy, Yugandhar B. S., Mukherjee, Sayandip, Pollakis, Georgios, Paxton, William A., Hoptroff, Michael

“…The ongoing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has highlighted the threat that viral outbreaks pose to global health. A key…”
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Diagnostic Accuracy of Dried Plasma Spot Specimens for HIV-1 Viral Load Testing: A Systematic Review and Meta-analysis by Fong, Youyi, Markby, Jessica, Andreotti, Mauro, Beck, Ingrid, Bourlet, Thomas, Brambilla, Don, Frenkel, Lisa, Lira, Rosalia, Nelson, Julie A. E., Pollakis, Georgios, Reigadas, Sandrine, Richman, Douglas, Sawadogo, Souleymane, Waters, Laura, Yang, Chunfu, Zeh, Clement, Doherty, Meg, Vojnov, Lara

“…Dried plasma spot specimens may be a viable alternative to traditional liquid plasma in field settings, but the diagnostic accuracy is not well understood…”
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Blood CXCR3 + CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals by Banga, Riddhima, Procopio, Francesco A, Ruggiero, Alessandra, Noto, Alessandra, Ohmiti, Khalid, Cavassini, Matthias, Corpataux, Jean-Marc, Paxton, William A, Pollakis, Georgios, Perreau, Matthieu

“…We recently demonstrated that lymph nodes (LNs) PD-1 /T follicular helper (Tfh) cells from antiretroviral therapy (ART)-treated HIV-infected individuals were…”
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Pseudotyping of VSV with Ebola virus glycoprotein is superior to HIV-1 for the assessment of neutralising antibodies by Steeds, Kimberley, Hall, Yper, Slack, Gillian S., Longet, Stephanie, Strecker, Thomas, Fehling, Sarah Katharina, Wright, Edward, Bore, Joseph Akoi, Koundouno, Fara Raymond, Konde, Mandy Kader, Hewson, Roger, Hiscox, Julian A., Pollakis, Georgios, Carroll, Miles W.

“…Ebola virus (EBOV) is an enveloped, single-stranded RNA virus that can cause Ebola virus disease (EVD). It is thought that EVD survivors are protected against…”
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Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease by Dong, Xiaofeng, Munoz-Basagoiti, Jordana, Rickett, Natasha Y, Pollakis, Georgios, Paxton, William A, Günther, Stephan, Kerber, Romy, Ng, Lisa F P, Elmore, Michael J, Magassouba, N'faly, Carroll, Miles W, Matthews, David A, Hiscox, Julian A

“…Viral load is a major contributor to outcome in patients with Ebola virus disease (EVD), with high values leading to a fatal outcome. Evidence from the…”
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Glycan dependent phenotype differences of HIV-1 generated from macrophage versus CD4 + T helper cell populations by Heeregrave, Edwin J, Thomas, Jordan, van Capel, Toni M, de Jong, Esther C, Pollakis, Georgios, Paxton, William A

“…Human immunodeficiency virus type 1 (HIV-1) is able to infect a variety of cell types with differences in entry efficiency and replication kinetics determined…”
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Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro by Mouser, Emily Eim, Pollakis, Georgios, Smits, Hermelijn H, Thomas, Jordan, Yazdanbakhsh, Maria, de Jong, Esther C, Paxton, William A

“…Parasitic helminths evade, skew and dampen human immune responses through numerous mechanisms. Such effects will likely have consequences for HIV-1…”
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The ecology of viruses in urban rodents with a focus on SARS-CoV-2 by Fisher, Adam M., Airey, George, Liu, Yuchen, Gemmell, Matthew, Thomas, Jordan, Bentley, Eleanor G., Whitehead, Mark A., Paxton, William A., Pollakis, Georgios, Paterson, Steve, Viney, Mark

“…Wild animals are naturally infected with a range of viruses, some of which may be zoonotic. During the human COVID pandemic there was also the possibility of…”
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Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach by Aljabr, Waleed, Touzelet, Olivier, Pollakis, Georgios, Wu, Weining, Munday, Diane C, Hughes, Margaret, Hertz-Fowler, Christiane, Kenny, John, Fearns, Rachel, Barr, John N, Matthews, David A, Hiscox, Julian A

“…Human respiratory syncytial virus (HRSV) is a major cause of serious respiratory tract infection. Treatment options include administration of ribavirin, a…”
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Generation of Liposomes to Study the Effect of Mycobacterium Tuberculosis Lipids on HIV-1 cis - and trans -Infections by Pouget, Marion, Coussens, Anna K, Ruggiero, Alessandra, Koch, Anastasia, Thomas, Jordan, Besra, Gurdyal S, Wilkinson, Robert J, Bhatt, Apoorva, Pollakis, Georgios, Paxton, William A

“…Tuberculosis (TB) is the leading cause of death among HIV-1-infected individuals and ( ) co-infection is an early precipitate to AIDS. We aimed to determine…”
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The HCV Envelope Glycoprotein Down-Modulates NF-κB Signalling and Associates With Stimulation of the Host Endoplasmic Reticulum Stress Pathway by McKay, Lindsay G A, Thomas, Jordan, Albalawi, Wejdan, Fattaccioli, Antoine, Dieu, Marc, Ruggiero, Alessandra, McKeating, Jane A, Ball, Jonathan K, Tarr, Alexander W, Renard, Patricia, Pollakis, Georgios, Paxton, William A

“…Following acute HCV infection, the virus establishes a chronic disease in the majority of patients whilst few individuals clear the infection spontaneously…”
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High Resolution Analysis of Respiratory Syncytial Virus Infection In Vivo by Aljabr, Waleed, Armstrong, Stuart, Rickett, Natasha Y., Pollakis, Georgios, Touzelet, Olivier, Cloutman-Green, Elaine, Matthews, David A., Hiscox, Julian A.

“…Human respiratory syncytial virus (HRSV) is a major cause of pediatric infection and also causes disease in the elderly and those with underlying respiratory…”
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Systematic comparison of HIV-1 Envelope-specific IgG responses induced by different vaccination regimens: Can we steer IgG recognition towards regions of viral vulnerability? by Horvath, Augusta, Rogers, Lisa, Pollakis, Georgios, Baranov, Olga, Pieroth, Nora, Joseph, Sarah, Chachage, Mkunde, Heitzer, Asli, Maganga, Lucas, Msafiri, Frank, Joachim, Agricola, Viegas, Edna, Eller, Leigh-Anne, Kibuuka, Hannah, Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Nitayapan, Sorachai, Dhitavat, Jittima, Premsri, Nakorn, Fidler, Sarah, Shattock, Robin J, Robb, Merlin Lee, Weber, Jonathan, McCormack, Sheena, Munseri, Patricia Jane, Lyamuya, Eligius, Nilsson, Charlotta, Kroidl, Arne, Hoelscher, Michael, Wagner, Ralf, Geldmacher, Christof, Held, Kathrin

“…Immunogens and vaccination regimens can influence patterns of immune-epitope recognition, steering them towards or away from epitopes of potential viral…”
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Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising Human Alu Repeat Sequences by Malatinkova, Eva, Thomas, Jordan, De Spiegelaere, Ward, Rutsaert, Sofie, Geretti, Anna Maria, Pollakis, Georgios, Paxton, William A, Vandekerckhove, Linos, Ruggiero, Alessandra

“…Integrated HIV-1 DNA persists despite antiretroviral therapy and can fuel viral rebound following treatment interruption. Hence, methods to specifically…”
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Dendritic cell-induced activation of latent HIV-1 provirus in actively proliferating primary T lymphocytes by van der Sluis, Renée M, van Montfort, Thijs, Pollakis, Georgios, Sanders, Rogier W, Speijer, Dave, Berkhout, Ben, Jeeninga, Rienk E

“…HIV-1 latency remains a formidable barrier towards virus eradication as therapeutic attempts to purge these reservoirs are so far unsuccessful. The pool of…”
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Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses by Hauser, Alexandra, Carnell, George, Held, Kathrin, Sulbaran, Guidenn, Tischbierek, Nadine, Rogers, Lisa, Pollakis, Georgios, Tonks, Paul, Hoelscher, Michael, Ding, Song, Sanders, Rogier W, Geldmacher, Christof, Sattentau, Quentin, Weissenhorn, Winfried, Heeney, Jonathan L, Peterhoff, David, Wagner, Ralf

“…Stabilization of the HIV-1 Envelope glycoprotein trimer (Env) in its native pre-fusion closed conformation is regarded as one of several requirements for the…”
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Induction of Identical IgG HIV-1 Envelope Epitope Recognition Patterns After Initial HIVIS-DNA/MVA-CMDR Immunization and a Late MVA-CMDR Boost by Joachim, Agricola, Ahmed, Mohamed I M, Pollakis, Georgios, Rogers, Lisa, Hoffmann, Verena S, Munseri, Patricia, Aboud, Said, Lyamuya, Eligius F, Bakari, Muhammad, Robb, Merlin L, Wahren, Britta, Sandstrom, Eric, Nilsson, Charlotta, Biberfeld, Gunnel, Geldmacher, Christof, Held, Kathrin

“…In the RV144 trial, to date the only HIV-1 vaccine efficacy trial demonstrating a modestly reduced risk of HIV-1 acquisition, antibody responses toward the HIV…”
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Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4+ Th-Cells by Mouser, Emily E I M, Pollakis, Georgios, Yazdanbakhsh, Maria, Harnett, William, de Jong, Esther C, Paxton, William A

“…One of the hallmarks of HIV-1 disease is the association of heightened CD4+ T-cell activation with HIV-1 replication. Parasitic helminths including filarial…”
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