Search Results - "Pollak, Richard"

Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies by Elewski, Boni E., MD, Aly, Raza, PhD, Baldwin, Sheryl L., RN, González Soto, Remigio F., MD, Rich, Phoebe, MD, Weisfeld, Max, DPM, Wiltz, Hector, MD, CPI, Zane, Lee T., MD, Pollak, Richard, DPM, MS

“…Background Onychomycosis, a fungal nail infection, can impact quality of life. Objective We sought to evaluate the efficacy and safety of tavaborole topical…”
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Efinaconazole 10% solution in the treatment of toenail onychomycosis: Two phase III multicenter, randomized, double-blind studies by Elewski, Boni E., MD, Rich, Phoebe, MD, Pollak, Richard, DPM, Pariser, David M., MD, Watanabe, Shinichi, MD, Senda, Hisato, DVM, Ieda, Chikara, PharB, Smith, Kathleen, MBA, Pillai, Radhakrishnan, PhD, Ramakrishna, Tage, MD, Olin, Jason T., PhD

“…Background Onychomycosis is a common nail infection, often resulting in nail plate damage and deformity. Topical lacquer treatments have negligible efficacy…”
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Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults by DiazGranados, Carlos A, Dunning, Andrew J, Kimmel, Murray, Kirby, Daniel, Treanor, John, Collins, Avi, Pollak, Richard, Christoff, Janet, Earl, John, Landolfi, Victoria, Martin, Earl, Gurunathan, Sanjay, Nathan, Richard, Greenberg, David P, Tornieporth, Nadia G, Decker, Michael D, Talbot, H. Keipp

“…Improving the efficacy of influenza vaccination in older adults is a challenge. In this randomized clinical trial, a high-dose influenza vaccine was shown to…”
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Selective Inhibition of NaV1.8 with VX-548 for Acute Pain by Jones, Jim, Correll, Darin J., Lechner, Sandra M., Jazic, Ina, Miao, Xiaopeng, Shaw, David, Simard, Christopher, Osteen, Jeremiah D., Hare, Brian, Beaton, Alina, Bertoch, Todd, Buvanendran, Asokumar, Habib, Ashraf S., Pizzi, Lois J., Pollak, Richard A., Weiner, Scott G., Bozic, Carmen, Negulescu, Paul, White, Paul F.

“…A selective blocker of the sodium channel Na V 1.8 that is expressed in peripheral nociceptive neurons of the dorsal-root ganglia had an effect on pain after…”
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Mechanism of action of HTX-011: a novel, extended-release, dual-acting local anesthetic formulation for postoperative pain by Ottoboni, Thomas, Quart, Barry, Pawasauskas, Jayne, Dasta, Joseph F, Pollak, Richard A, Viscusi, Eugene R

“…Background and objectivesObtaining consistent efficacy beyond 12–24 hours with local anesthetics, including extended-release formulations, has been a…”
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HTX-011 Reduced Pain and Opioid Use After Primary Total Knee Arthroplasty: Results of a Randomized Phase 2b Trial by Lachiewicz, Paul F., Lee, Gwo-Chin, Pollak, Richard A., Leiman, David G., Hu, Jia, Sah, Alexander P.

“…HTX-011 is an extended-release, dual-acting local anesthetic consisting of bupivacaine and low-dose meloxicam in a novel polymer that is administered by…”
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Response to the letter to the editor by Hafer and Johnson concerning ‘Mechanism of action of HTX-011: a novel, extended-release, dual-acting local anesthetic formulation for postoperative pain’ by Ottoboni, Thomas, Quart, Barry, Pawasauskas, Jayne, Dasta, Joseph F, Pollak, Richard A, Viscusi, Eugene R

“…The early proof-of-concept phase II bunionectomy study presented in our manuscript2 confirmed the preclinical findings and demonstrated that HTX-011 resulted…”
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Selective Inhibition of Na V 1.8 with VX-548 for Acute Pain by Jones, Jim, Correll, Darin J, Lechner, Sandra M, Jazic, Ina, Miao, Xiaopeng, Shaw, David, Simard, Christopher, Osteen, Jeremiah D, Hare, Brian, Beaton, Alina, Bertoch, Todd, Buvanendran, Asokumar, Habib, Ashraf S, Pizzi, Lois J, Pollak, Richard A, Weiner, Scott G, Bozic, Carmen, Negulescu, Paul, White, Paul F

“…The Na 1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548,…”
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Efficacy and Safety of Intravenous Meloxicam in Patients With Moderate-to-Severe Pain Following Bunionectomy: A Randomized, Double-Blind, Placebo-controlled Trial by Pollak, Richard A, Gottlieb, Ira J, Hakakian, Fardin, Zimmerman, John C, McCallum, Stewart W, Mack, Randall J, Keller, Rosemary, Freyer, Alex, Du, Wei

“…OBJECTIVE:To evaluate the analgesic efficacy and safety of a novel intravenous (IV) formulation of meloxicam (30 mg) in patients with moderate-to-severe pain…”
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Efinaconazole topical solution, 10%: the development of a new topical treatment for toenail onychomycosis by Pollak, Richard A

“…Toenail onychomycosis is a common disease with limited treatment options; treatment failure and relapse are frequently encountered. Many patients experience…”
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Access of efinaconazole topical solution, 10%, to the infection site by spreading through the subungual space by Elewski, Boni E, Pollak, Richard A, Pillai, Radhakrishnan, Olin, Jason T

“…To evaluate the ability of efinaconazole vehicle to reach the site of toenail onychomycosis by spreading through the subungual space between the nail plate and…”
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Efficacy of Collagenase Clostridium Histolyticum Injection, a Potential Nonsurgical Intralesional Treatment Option for Plantar Fibromatosis: A Randomized, Open-Label, Dose-Ranging Study by Caporusso, Joseph, Pollak, Richard, Hernandez, David, Dalton, Shannon, Xiang, Qinfang, Vijayan, Saji, Anderson, C. James

“…Category: Midfoot/Forefoot; Basic Sciences/Biologics Introduction/Purpose: Plantar fibromatosis (PFi) is characterized by collagen-containing nodules on the…”
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Participant Satisfaction and Investigator Assessment of Collagenase Clostridium Histolyticum Injection as a Nonsurgical Intralesional Treatment Option for Plantar Fibromatosis by Anderson, C. James, Pollak, Richard, Dalton, Shannon, Xiang, Qinfang, Vijayan, Saji, Ortega, Luis A., Caporusso, Joseph

“…Category: Midfoot/Forefoot; Basic Sciences/Biologics Introduction/Purpose: Currently, there is no safe and efficacious injectable therapy for symptomatic…”
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Tolerability and Safety of Collagenase Clostridium Histolyticum Injection in Participants with Plantar Fibromatosis by Pollak, Richard, Anderson, C. James, Hernandez, David, Xiang, Qinfang, Vijayan, Saji, Ortega, Luis A., Caporusso, Joseph

“…Category: Midfoot/Forefoot; Basic Sciences/Biologics Introduction/Purpose: Plantar fibromatosis (PFi) is a functionally disabling disorder characterized by…”
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Efficacy and Safety of Intravenously Administered Tramadol in Patients with Moderate to Severe Pain Following Bunionectomy: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study by Singla, Neil K., Pollak, Richard, Gottlieb, Ira, Leiman, David, Minkowitz, Harold, Zimmerman, John, Harnett, Mark, Ryan, Michael, Lu, Lucy, Reines, Scott

“…Introduction This study is part of the registrational program for intravenously administered (IV) tramadol in the USA and compared the analgesic benefit and…”
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The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis by Toledo-Bahena, Mirna E, Bucko, Alicia, Ocampo-Candiani, Jorge, Herz-Ruelas, Maira E, Jones, Terry M, Jarratt, Michael T, Pollak, Richard A, Zane, Lee T

“…To assess the potential efficacy, safety, and optimal dosing concentration of tavaborole, a novel, boron-based pharmaceutical agent with broad-spectrum…”
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Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success by Pollak, Richard A, Siu, William J Jo, Tatsumi, Yoshiyuki, Pillai, Radhakrishnan

“…To provide an adequate therapeutic effect against onychomycosis, it has been suggested that topical drugs should have two properties: drug permeability through…”
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Opioid-Free Recovery from Bunionectomy with HTX-011, a Dual-Acting Local Anesthetic Combining Bupivacaine and Meloxicam, as the Foundation of Non-Opioid Multimodal Analgesia by Pollak, Richard, Cai, Danlin, Gan, Tong J

“…There is a need for postoperative pain control that minimizes/eliminates opioid use during the first 72 hours following surgery, when pain is most severe…”
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The Efficacy and Safety of Dermagraft in Improving the Healing of Chronic Diabetic Foot Ulcers by Marston, William A., Hanft, Jason, Norwood, Paul, Pollak, Richard

“…The Efficacy and Safety of Dermagraft in Improving the Healing of Chronic Diabetic Foot Ulcers Results of a prospective randomized trial William A. Marston ,…”
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Efinaconazole Topical Solution, 10 by Pollak, Richard A.

“…Background Toenail onychomycosis is a common disease with limited treatment options; treatment failure and relapse are frequently encountered. Many patients…”
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