Search Results - "Pollack, Lois"

SAXS Studies of Ion-Nucleic Acid Interactions by Pollack, Lois

“…Positively charged ions, atoms, or molecules compensate the high negative charge of the nucleic acid backbone. Their presence is critical to the biological…”
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Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2) by Kelly, Jamie A., Olson, Alexandra N., Neupane, Krishna, Munshi, Sneha, San Emeterio, Josue, Pollack, Lois, Woodside, Michael T., Dinman, Jonathan D.

“…Approximately 17 years after the severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic, the world is currently facing the COVID-19 pandemic caused…”
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Double-focusing mixing jet for XFEL study of chemical kinetics by Wang, Dingjie, Weierstall, Uwe, Pollack, Lois, Spence, John

“…Several liquid sample injection methods have been developed to satisfy the requirements for serial femtosecond X‐ray nanocrystallography, which enables…”
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Ionic strength-dependent persistence lengths of single-stranded RNA and DNA by Chen, Huimin, Meisburger, Steve P, Pabit, Suzette A, Sutton, Julie L, Webb, Watt W, Pollack, Lois

“…Dynamic RNA molecules carry out essential processes in the cell including translation and splicing. Base-pair interactions stabilize RNA into relatively rigid…”
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Electrostatics of strongly charged biological polymers: ion-mediated interactions and self-organization in nucleic acids and proteins by Wong, Gerard C L, Pollack, Lois

“…Charges on biological polymers in physiologically relevant solution conditions are strongly screened by water and salt solutions containing counter-ions…”
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Asymmetric unwrapping of nucleosomal DNA propagates asymmetric opening and dissociation of the histone core by Chen, Yujie, Tokuda, Joshua M., Topping, Traci, Meisburger, Steve P., Pabit, Suzette A., Gloss, Lisa M., Pollack, Lois

“…The nucleosome core particle (NCP) is the basic structural unit for genome packaging in eukaryotic cells and consists of DNA wound around a core of eight…”
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Determining the Locations of Ions and Water around DNA from X-Ray Scattering Measurements by Meisburger, Steve P., Pabit, Suzette A., Pollack, Lois

“…Nucleic acids carry a negative charge, attracting salt ions and water. Interactions with these components of the solvent drive DNA to condense, RNA to fold,…”
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Opposing Effects of Multivalent Ions on the Flexibility of DNA and RNA by Drozdetski, Aleksander V, Tolokh, Igor S, Pollack, Lois, Baker, Nathan, Onufriev, Alexey V

“…Increasing the concentration of counterions (salt) is known to reduce the bending persistence length of DNA. Here we use atomistic molecular dynamics…”
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Author Correction: Cation-induced intramolecular coil-to-globule transition in poly(ADP-ribose) by Wang, Tong, Coshic, Kush, Badiee, Mohsen, McDonald, Maranda R., Aksimentiev, Aleksei, Pollack, Lois, Leung, Anthony K. L.

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Cation-induced intramolecular coil-to-globule transition in poly(ADP-ribose) by Wang, Tong, Coshic, Kush, Badiee, Mohsen, McDonald, Maranda R., Aksimentiev, Aleksei, Pollack, Lois, Leung, Anthony K. L.

“…Poly(ADP-ribose) (PAR), a non-canonical nucleic acid, is essential for DNA/RNA metabolism and protein condensation, and its dysregulation is linked to cancer…”
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Flavin reduction activates Drosophila cryptochrome by Vaidya, Anand T., Top, Deniz, Manahan, Craig C., Tokuda, Joshua M., Zhang, Sheng, Pollack, Lois, Young, Michael W., Crane, Brian R.

“…Entrainment of circadian rhythms in higher organisms relies on light-sensing proteins that communicate to cellular oscillators composed of delayed…”
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Machine learning deciphers structural features of RNA duplexes measured with solution X-ray scattering by Chen, Yen-Lin, Pollack, Lois

“…Macromolecular structures can be determined from solution X-ray scattering. Small-angle X-ray scattering (SAXS) provides global structural information on…”
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Heterogeneity in M. tuberculosis β-lactamase inhibition by Sulbactam by Malla, Tek Narsingh, Zielinski, Kara, Aldama, Luis, Bajt, Sasa, Feliz, Denisse, Hayes, Brendon, Hunter, Mark, Kupitz, Christopher, Lisova, Stella, Knoska, Juraj, Martin-Garcia, Jose Manuel, Mariani, Valerio, Pandey, Suraj, Poudyal, Ishwor, Sierra, Raymond G., Tolstikova, Alexandra, Yefanov, Oleksandr, Yoon, Chung Hong, Ourmazd, Abbas, Fromme, Petra, Schwander, Peter, Barty, Anton, Chapman, Henry N., Stojkovic, Emina A., Batyuk, Alexander, Boutet, Sébastien, Phillips, George N., Pollack, Lois, Schmidt, Marius

“…For decades, researchers have elucidated essential enzymatic functions on the atomic length scale by tracing atomic positions in real-time. Our work builds on…”
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T box RNA decodes both the information content and geometry of tRNA to affect gene expression by Grigg, Jason C., Chen, Yujie, Grundy, Frank J., Henkin, Tina M., Pollack, Lois, Ke, Ailong

“…The T box leader sequence is an RNA element that controls gene expression by binding directly to a specific tRNA and sensing its aminoacylation state. This…”
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Small-Angle X-ray Scattering and Single-Molecule FRET Spectroscopy Produce Highly Divergent Views of the Low-Denaturant Unfolded State by Yoo, Tae Yeon, Meisburger, Steve P., Hinshaw, James, Pollack, Lois, Haran, Gilad, Sosnick, Tobin R., Plaxco, Kevin

“…The results of more than a dozen single-molecule Förster resonance energy transfer (smFRET) experiments suggest that chemically unfolded polypeptides…”
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Mixing injector enables time-resolved crystallography with high hit rate at X-ray free electron lasers by Calvey, George D., Katz, Andrea M., Schaffer, Chris B., Pollack, Lois

“…Knowledge of protein structure provides essential insight into function, enhancing our understanding of diseases and enabling new treatment development. X-ray…”
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The ATPase motor of the Chd1 chromatin remodeler stimulates DNA unwrapping from the nucleosome by Tokuda, Joshua M, Ren, Ren, Levendosky, Robert F, Tay, Rebecca J, Yan, Ming, Pollack, Lois, Bowman, Gregory D

“…Abstract Chromatin remodelers are ATP-dependent motors that reorganize DNA packaging by disrupting canonical histone-DNA contacts within the nucleosome. Here,…”
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Inter-DNA attraction mediated by divalent counterions by Qiu, Xiangyun, Andresen, Kurt, Kwok, Lisa W, Lamb, Jessica S, Park, Hye Yoon, Pollack, Lois

“…Can nonspecifically bound divalent counterions induce attraction between DNA strands? Here, we present experimental evidence demonstrating attraction between…”
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Distinct conformational states enable transglutaminase 2 to promote cancer cell survival versus cell death by Aplin, Cody, Zielinski, Kara A., Pabit, Suzette, Ogunribido, Deborah, Katt, William P., Pollack, Lois, Cerione, Richard A., Milano, Shawn K.

“…Transglutaminase 2 (TG2) is a GTP-binding, protein-crosslinking enzyme that has been investigated as a therapeutic target for Celiac disease, neurological…”
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Conformational changes of calmodulin upon Ca²⁺ binding studied with a microfluidic mixer by Park, Hye Yoon, Kim, Sally A, Korlach, Jonas, Rhoades, Elizabeth, Kwok, Lisa W, Zipfel, Warren R, Waxham, M. Neal, Webb, Watt W, Pollack, Lois

“…A microfluidic mixer is applied to study the kinetics of calmodulin conformational changes upon Ca²⁺ binding. The device facilitates rapid, uniform mixing by…”
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