Search Results - "Pollack, GM"

P-Glycoprotein attenuates brain uptake of substrates after nasal instillation by GRAFF, Candace L, POLLACK, Gary M

“…Previous literature has suggested the absence of an effective barrier between the nasal mucosa and the brain for compounds administered via the nasal route…”
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Pharmacokinetic and Pharmacodynamic Implications of P-glycoprotein Modulation by Matheny, Christopher J., Lamb, Matthew W., Brouwer, Kim L. R., Pollack, Gary M.

“…P‐glycoprotein (P‐gp) is a cell membrane—associated protein that transports a variety of drug substrates. Although P‐gp has been studied extensively as a…”
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The development of morphine antinociceptive tolerance in nitric oxide synthase-deficient mice by Heinzen, Erin L, Pollack, Gary M

“…Elevations in nitric oxide (NO) have been implicated in the development of morphine antinociceptive tolerance. This study was conducted to establish the role…”
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Effects of a Potent and Specific P-Glycoprotein Inhibitor on the Blood-Brain Barrier Distribution and Antinociceptive Effect of Morphine in the Rat by LETRENT, S. P, POLLACK, G. M, BROUWER, K. R, BROUWER, K. L. R

“…Previous data suggest that the analgesic effect of morphine may be modulated by P-glycoprotein (P-gp) inhibition. The effects of the P-gp inhibitor GF120918 on…”
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Contribution of Morphine-6-Glucuronide to Antinociception following Intravenous Administration of Morphine to Healthy Volunteers by Murthy, Bindu P., Pollack, Gary M., Brouwer, Kim L. R.

“…This study was performed to develop an integrated pharmacokinetic‐pharmacodynamic model for estimating the contribution of morphine‐6‐glucuronide (M6G) to…”
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P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells by Letrent, Stephen P., Polli, Joseph W., Humphreys, Joan E., Pollack, Gary M., Brouwer, Kenneth R., Brouwer, Kim L.R.

“…Cell accumulation, transendothelial permeability, and efflux studies were conducted in bovine brain capillary endothelial cells (BBCECs) to assess the role of…”
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Nasal drug administration: potential for targeted central nervous system delivery by Graff, Candace L, Pollack, Gary M

“…Nasal administration as a means of delivering therapeutic agents preferentially to the brain has gained significant recent interest. While some substrates…”
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Pharmacodynamics and tolerance development during multiple intravenous bolus morphine administration in rats by Ouellet, D M, Pollack, G M

“…Limited information is available about how the time course of the development of tolerance to morphine-induced antinociception is related to the kinetics of…”
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Biliary excretion and enterohepatic recirculation of morphine-3-glucuronide in rats by Ouellet, D M, Pollack, G M

“…Morphine elimination is characterized by a prolonged terminal elimination phase, at least in part because of enterohepatic recirculation (EHR) of morphine as…”
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Variable modulation of opioid brain uptake by P-glycoprotein in mice by Dagenais, Claude, Graff, Candace L., Pollack, Gary M.

“…The efflux transporter P-glycoprotein (P-gp) is an important component of the blood–brain barrier (BBB) that limits accumulation of many compounds in brain…”
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Blood-brain barrier efflux transport by Golden, Pamela L, Pollack, Gary M

“…Efflux transport at the blood-brain barrier (BBB) limits the brain tissue exposure to a variety of potential therapeutic agents, including compounds that are…”
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Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective by Dumas, Emily O., Pollack, Gary M.

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Drug transport at the blood-brain barrier and the choroid plexus by Graff, Candace L, Pollack, Gary M

“…The blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) represent the main interfaces between the central nervous system (CNS) and the peripheral…”
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Enterohepatic recirculation and renal metabolism of morphine in the rat by Horton, T L, Pollack, G M

“…Morphine (2.5 mg/kg) was administered iv to intact (I), bile duct-cannulated (BC), and bile duct-cannulated--renal-ligated (BC-RL) rats (n = 4 per group) to…”
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Functional evidence for P-glycoprotein at the nose-brain barrier by Graff, Candace L, Pollack, Gary M

“…Experiments were performed to assess the brain distribution of [3H]-verapamil, including the influence of delivery route of inhibitor and substrate (nasal vs…”
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Comparison of a New Intranasal Naloxone Formulation to Intramuscular Naloxone: Results from Hypothesis‐generating Small Clinical Studies by Gufford, BT, Ainslie, GR, White, JR, Layton, ME, Padowski, JM, Pollack, GM, Paine, MF

“…Easy‐to‐use naloxone formulations are needed to help address the opioid overdose epidemic. The pharmacokinetics of i.v., i.m., and a new i.n. naloxone…”
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Evidence for reversible sequestration of morphine in rat liver by Matheny, Christopher J, Taft, David R., Brouwer, Kim L.R., Pollack, Gary M.

“…The residence of morphine in the systemic circulation is prolonged despite a high systemic clearance, suggestive of significant extravascular sequestration…”
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Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin by Zong, Jian, Pollack, Gary M

“…The objective of the present study was to examine the time course and concentration dependence of modulation of P-glycoprotein (P-gp) activity in the…”
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Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver by Zamek-Gliszczynski, Maciej J, Xiong, Hao, Patel, Nita J, Turncliff, Ryan Z, Pollack, Gary M, Brouwer, Kim L R

“…Hepatic disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein (CDF) and its diacetate promoiety (CDFDA) was studied in isolated perfused rat livers…”
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A pharmacokinetic-pharmacodynamic model of tolerance to morphine analgesia during infusion in rats by Ouellet, D M, Pollack, G M

“…A pharmacokinetic-pharmacodynamic (PK-PD) model was constructed to describe the kinetics of tolerance development to morphine-induced antinociception…”
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