Search Results - "Polkey, M. I."

The prevalence of quadriceps weakness in COPD and the relationship with disease severity by SEYMOUR, J. M, SPRUIT, M. A, WOUTERS, E. F. M, HOPKINSON, N. S, NATANEK, S. A, MAN, W. D-C, JACKSON, A, GOSKER, H. R, SCHOLS, A. M. W. J, MOXHAM, J, POLKEY, M. I

“…Quadriceps strength relates to exercise capacity and prognosis in chronic obstructive pulmonary disease (COPD). We wanted to quantify the prevalence of…”
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Ultrasound measurement of rectus femoris cross-sectional area and the relationship with quadriceps strength in COPD by Seymour, J M, Ward, K, Sidhu, P S, Puthucheary, Z, Steier, J, Jolley, C J, Rafferty, G, Polkey, M I, Moxham, J

“…Quadriceps weakness and loss of muscle mass predict mortality in chronic obstructive pulmonary disease (COPD). It was hypothesised that a reduced quadriceps…”
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Atelectasis and survival after bronchoscopic lung volume reduction for COPD by HOPKINSON, N. S, KEMP, S. V, TOMA, T. P, HANSELL, D. M, GEDDES, D. M, SHAH, P. L, POLKEY, M. I

“…Bronchoscopic therapies to reduce lung volumes in chronic obstructive pulmonary disease are intended to avoid the risks associated with lung volume reduction…”
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Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs by Bloch, S A A, Lee, J Y, Syburra, T, Rosendahl, U, Griffiths, M J D, Kemp, P R, Polkey, M I

“…The molecular mechanisms underlying the muscle atrophy of intensive care unit-acquired weakness (ICUAW) are poorly understood. We hypothesised that increased…”
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Neural respiratory drive in obesity by Steier, J, Jolley, C J, Seymour, J, Roughton, M, Polkey, M I, Moxham, J

“…The load imposed on ventilation by increased body mass contributes to the respiratory symptoms caused by obesity. A study was conducted to quantify ventilatory…”
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Neural respiratory drive in healthy subjects and in COPD by Jolley, C. J, Luo, Y-M, Steier, J, Reilly, C, Seymour, J, Lunt, A, Ward, K, Rafferty, G. F, Polkey, M. I, Moxham, J

“…The aim of the present study was to use the diaphragm electromyogram (EMG(di)) to compare levels of neural respiratory drive (NRD) in a cohort of healthy…”
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Molecular mechanisms of intensive care unit-acquired weakness by BLOCH, S, POLKEY, M. I, GRIFFITHS, M, KEMP, P

“…Intensive care unit-acquired weakness (ICUAW) is an increasingly recognised and important clinical consequence of critical illness. It is associated with…”
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Cytokine profile in quadriceps muscles of patients with severe COPD by Barreiro, E, Schols, A M W J, Polkey, M I, Galdiz, J B, Gosker, H R, Swallow, E B, Coronell, C, Gea, J

“…Systemic proinflammatory cytokines and oxidative stress have been described in association with peripheral muscle wasting and weakness of patients with severe…”
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Acute ischaemic hemispheric stroke is associated with impairment of reflex in addition to voluntary cough by WARD, K, SEYMOUR, J, STEIER, J, JOLLEY, C. J, POLKEY, M. I, KALRA, L, MOXHAM, J

“…Cough function is impaired after stroke; this may be important for protection against chest infection. Reflex cough (RC) intensity indices have not been…”
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Cough augmentation with mechanical insufflation/exsufflation in patients with neuromuscular weakness by Chatwin, M, Ross, E, Hart, N, Nickol, A.H, Polkey, M.I, Simonds, A.K

“…Adults and children with neuromuscular disease exhibit weak cough and are susceptible to recurrent chest infections, a major cause of morbidity and mortality…”
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A novel technique for nonvolitional assessment of quadriceps muscle endurance in humans by Swallow, E. B, Gosker, H. R, Ward, K. A, Moore, A. J, Dayer, M. J, Hopkinson, N. S, Schols, A. M. W. J, Moxham, J, Polkey, M. I

“…1 Respiratory Muscle Laboratory, Royal Brompton Hospital, London, United Kingdom; 2 Department of Respiratory Medicine, University of Maastricht, Maastricht,…”
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Respiratory muscle strength and ventilatory failure in amyotrophic lateral sclerosis by Lyall, R. A., Donaldson, N., Polkey, M. I., Leigh, P. N., Moxham, J.

“…Although ventilatory failure is the most common cause of death in amyotrophic lateral sclerosis (ALS) and measurement of respiratory muscle strength (RMS) has…”
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Analysis of home support and ventilator malfunction in 1,211 ventilator-dependent patients by Chatwin, M, Heather, S, Hanak, A, Polkey, M. I, Simonds, A. K

“…Risk management is an important aspect of home ventilation (HV). We examined the nature of calls to a home support helpline to identify patient/equipment…”
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The effect of noninvasive ventilation on ALS patients and their caregivers by MUSTFA, N, WALSH, E, BRYANT, V, LYALL, R. A, ADDINGTON-HALL, J, GOLDSTEIN, L. H, DONALDSON, N, POLKEY, M. I, MOXHAM, J, LEIGH, P. N

“…Noninvasive ventilation (NIV) reduces mortality and improves some aspects of quality of life (QoL) in ALS. However, concerns remain that progressive disability…”
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Magnetic stimulation for the measurement of respiratory and skeletal muscle function by Man, W.D-C, Moxham, J, Polkey, M.I

“…Respiratory and skeletal muscle function is of interest in many areas of pulmonary and critical care medicine. The capacity of the respiratory muscle pump to…”
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Mechanisms of improvement of respiratory failure in patients with restrictive thoracic disease treated with non-invasive ventilation by Nickol, A H, Hart, N, Hopkinson, N S, Moxham, J, Simonds, A, Polkey, M I

“…Background: Nocturnal non-invasive ventilation (NIV) is an effective treatment for hypercapnic respiratory failure in patients with restrictive thoracic…”
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Sleep-disordered breathing in unilateral diaphragm paralysis or severe weakness by Steier, J, Jolley, C. J, Seymour, J, Kaul, S, Luo, Y. M, Rafferty, G. F, Hart, N, Polkey, M. I, Moxham, J

“…Few data exist concerning sleep in patients with hemidiaphragm paralysis or weakness. Traditionally, such patients are considered to sustain normal ventilation…”
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A prospective study of quality of life in ALS patients treated with noninvasive ventilation by LYALL, R. A, DONALDSON, N, FLEMING, T, WOOD, C, NEWSOM-DAVIS, I, POLKEY, M. I, LEIGH, P. N, MOXHAM, J

“…Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of…”
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Screening for sleep-disordered breathing in neuromuscular disease using a questionnaire for symptoms associated with diaphragm paralysis by STEIER, J, JOLLEY, C. J, SEYMOUR, J, TESCHLER, H, LUO, Y. M, POLKEY, M. I, MOXHAM, J

“…Patients with neuromuscular disease (NMD) are at risk of developing sleep-disordered breathing (SDB) following respiratory muscle involvement. We hypothesised…”
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Proportional assist ventilation as an aid to exercise training in severe chronic obstructive pulmonary disease by Hawkins, P, Johnson, L C, Nikoletou, D, Hamnegård, C-H, Sherwood, R, Polkey, M I, Moxham, J

“…Background: The effects of providing ventilatory assistance to patients with severe chronic obstructive pulmonary disease (COPD) during a high intensity…”
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