Search Results - "Polk, D"

Probiotics and Probiotic-Derived Functional Factors-Mechanistic Insights Into Applications for Intestinal Homeostasis by Yan, Fang, Polk, D Brent

“…Advances in our understanding of the contribution of the gut microbiota to human health and the correlation of dysbiosis with diseases, including chronic…”
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Helicobacter pylori : gastric cancer and beyond by Peek, Richard M, Polk, D. Brent

“…Key Points Infection with Helicobacter pylori is the strongest known risk factor for gastric adenocarcinoma, but only a minority of colonized individuals…”
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Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases by Vanderpool, Charles, Yan, Fang, Polk, D. Brent

“…Probiotics are defined as nonpathogenic living microorganisms, including some commensal bacterial flora, which have beneficial effects on host health and…”
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Bedside Intestinal Ultrasound Predicts Disease Severity and the Disease Distribution of Pediatric Patients With Inflammatory Bowel Disease: A Pilot Cross-sectional Study by Chavannes, Mallory, Hart, Lara, Hayati Rezvan, Panteha, Dillman, Jonathan R, Polk, D Brent

“…Intestinal ultrasound (IUS) is a noninvasive tool to assess bowel inflammation. There is a paucity of data on its accuracy in pediatric patients. The aim of…”
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Probiotics and immune health by Yan, Fang, Polk, D.B

“…PURPOSE OF REVIEWThe beneficial effects of probiotics have been demonstrated in many diseases. One of the major mechanisms of probiotic action is through the…”
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Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells by Yan, Fang, Polk, D. Brent

“…Probiotic bacteria are microorganisms that benefit the host by preventing or ameliorating disease. However, little information is known regarding the…”
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Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor by Wang, Lihong, Liu, Liping, Shi, Yan, Cao, Hanwei, Chaturvedi, Rupesh, Calcutt, M Wade, Hu, Tianhui, Ren, Xiubao, Wilson, Keith T, Polk, D Brent, Yan, Fang

“…Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although…”
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Soluble Proteins Produced by Probiotic Bacteria Regulate Intestinal Epithelial Cell Survival and Growth by Yan, Fang, Cao, Hanwei, Cover, Timothy L, Whitehead, Robert, Washington, M. Kay, Polk, D. Brent

“…Background & Aims: Increased inflammatory cytokine levels and intestinal epithelial cell apoptosis leading to disruption of epithelial integrity are major…”
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Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice by Yan, Fang, Wang, Lihong, Shi, Yan, Cao, Hanwei, Liu, Liping, Washington, M Kay, Chaturvedi, Rupesh, Israel, Dawn A, Cao, Hailong, Wang, Bangmao, Peek, Jr, Richard M, Wilson, Keith T, Polk, D Brent

“…Inflammatory bowel disease (IBD) results from dysregulation of intestinal mucosal immune responses to microflora in genetically susceptible hosts. A major…”
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Preserving viability of Lactobacillus rhamnosus GG in vitro and in vivo by a new encapsulation system by Li, Ran, Zhang, Yufeng, Polk, D. Brent, Tomasula, Peggy M., Yan, Fang, Liu, LinShu

“…Probiotics have shown beneficial effects on health and prevention of diseases in humans. However, a concern for application of probiotics is the loss of…”
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BDNF, endurance activity, and mechanisms underlying the evolution of hominin brains by Hill, Tyler, Polk, John D.

“…Objectives As a complex, polygenic trait, brain size has likely been influenced by a range of direct and indirect selection pressures for both cognitive and…”
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Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios by Weitkamp, Jörn-Hendrik, Koyama, Tatsuki, Rock, Michael T, Correa, Hernan, Goettel, Jeremy A, Matta, Pranathi, Oswald-Richter, Kyra, Rosen, Michael J, Engelhardt, Brian G, Moore, Daniel J, Polk, D Brent

“…Necrotising enterocolitis (NEC) is the most common gastrointestinal emergency in premature infants. Immaturity of gastrointestinal immune regulation may…”
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Production of a Functional Factor, p40, by Lactobacillus rhamnosus GG Is Promoted by Intestinal Epithelial Cell-Secreted Extracellular Vesicles by Yang, Luyao, Higginbotham, James N, Liu, Liping, Zhao, Gang, Acra, Sari A, Peek, Jr, Richard M, Polk, D Brent, Li, Hui, Yan, Fang

“…The symbiotic relationship between the gut microbiome and the host provides a nutrient-rich environment for gut microbes and has beneficial effects on host…”
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Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism by Yan, Fang, Cao, Hanwei, Cover, Timothy L, Washington, M. Kay, Shi, Yan, Liu, LinShu, Chaturvedi, Rupesh, Peek Jr., Richard M, Wilson, Keith T, Polk, D. Brent

“…Probiotic bacteria can potentially have beneficial effects on the clinical course of several intestinal disorders, but our understanding of probiotic action is…”
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Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism by Seth, A, Yan, Fang, Polk, D Brent, Rao, R K

“…Probiotics promote intestinal epithelial integrity and reduce infection and diarrhea. We evaluated the effect of Lactobacillus rhamnosus GG-produced soluble…”
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Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells by Wang, Lihong, Cao, Hailong, Lu, Ning, Liu, Liping, Wang, Bangmao, Hu, Tianhui, Israel, Dawn A, Peek, Jr, Richard M, Polk, D Brent, Yan, Fang

“…Berberine, an isoquinoline alkaloid, is an active component of Ranunculaceae and Papaveraceae plant families. Berberine has been found to suppress growth of…”
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Redeeming an old foe: protective as well as pathophysiological roles for tumor necrosis factor in inflammatory bowel disease by Dubé, Philip E, Punit, Shivesh, Polk, D Brent

“…Tumor necrosis factor (TNF) and its receptors TNFR1 and TNFR2 are major therapeutic targets for inflammatory bowel disease. Research advances have demonstrated…”
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Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis? by Waitzberg, Dan, Guarner, Francisco, Hojsak, Iva, Ianiro, Gianluca, Polk, D. Brent, Sokol, Harry

“…Dysbiosis corresponds to the disruption of a formerly stable, functionally complete microbiota. In the gut, this imbalance can lead to adverse health outcomes…”
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Predicting Persistence of Functional Abdominal Pain From Childhood Into Young Adulthood by Horst, Sara, Shelby, Grace, Anderson, Julia, Acra, Sari, Polk, D. Brent, Saville, Benjamin R, Garber, Judy, Walker, Lynn S

“…Background & Aims Pediatric functional abdominal pain has been linked to functional gastrointestinal disorders (FGIDs) in adulthood, but little is known about…”
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Neonatal colonization of mice with LGG promotes intestinal development and decreases susceptibility to colitis in adulthood by Yan, F, Liu, L, Cao, H, Moore, D J, Washington, M K, Wang, B, Peek, R M, Acra, S A, Polk, D B

“…Development of the intestinal microbiota during early life serves as a key regulatory stage in establishing the host–microbial relationship. This symbiotic…”
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