Search Results - "Polizzi, Donatella"

BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin by MANZOTTI, C, PRATESI, G, PEZZONI, G, ZUNINO, F, MENTA, E, DI DOMENICO, R, CAVALLETTI, E, FIEBIG, H. H, KELLAND, L. R, FARRELL, N, POLIZZI, D, SUPINO, R

“…Multinuclear platinum complexes represent a new class of anticancer agents, distinct in terms of DNA binding features and the profile of antitumor activity…”
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Role of apoptosis and apoptosis-related genes in cellular response and antitumor efficacy of anthracyclines by Perego, P, Corna, E, De Cesare, M, Gatti, L, Polizzi, D, Pratesi, G, Supino, R, Zunino, F

“…Cellular resistance to anthracyclines is a major limitation of their clinical use in the treatment of human tumors. Resistance to doxorubicin is described as a…”
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Oral Efficacy and Bioavailability of a Novel Taxane by Polizzi, D, Pratesi, G, Monestiroli, S, Tortoreto, M, Zunino, F, Bombardelli, E, Riva, A, Morazzoni, P, Colombo, T, D'Incalci, M, Zucchetti, M

“…A novel taxane (IDN 5109), originally selected for its ability to overcome P-glycoprotein-mediated drug resistance, is characterized by an improved preclinical…”
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Molecular mechanisms of resistance to taxanes and therapeutic implications by Zunino, Franco, Cassinelli, Giuliana, Polizzi, Donatella, Perego, Paola

“…The mechanism of resistance to taxanes has not been fully elucidated. Since Taxol is a substrate for P-glycoprotein, overexpression of this transport system is…”
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Growth‐inhibitory effects of luteinizing hormone‐releasing hormone (LHRH) agonists on xenografts of the DU 145 human androgen‐independent prostate cancer cell line in nude mice by Dondi, Donatella, Moretti, Roberta M., Marelli, Marina Montagnani, Pratesi, Graziella, Polizzi, Donatella, Milani, Mario, Motta, Marcella, Limonta, Patrizia

“…Experiments have been performed to clarify whether LHRH agonists might decrease growth of hormone‐unresponsive prostate cancer in vivo. Male nude mice were…”
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A novel 9-aza-anthrapyrazole effective against human prostatic carcinoma xenografts by Supino, R, Polizzi, D, Pavesi, R, Pratesi, G, Guano, F, Capranico, G, Palumbo, M, Sissi, C, Richter, S, Beggiolin, G, Menta, E, Pezzoni, G, Spinelli, S, Torriani, D, Carenini, N, Dal Bo, L, Facchinetti, F, Tortoreto, M, Zunino, F

“…Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438…”
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Reversal of multidrug resistance by the P-glycoprotein modulator, LY335979, from the bench to the clinic by Dantzig, A H, Law, K L, Cao, J, Starling, J J

“…Multidrug resistance may be conferred by P-glycoprotein (Pgp, ABCB1) or the multidrug resistance associated protein (MRP). These membrane proteins are members…”
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A role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanes by Cassinelli, Giuliana, Supino, Rosanna, Perego, Paola, Polizzi, Donatella, Lanzi, Cinzia, Pratesi, Graziella, Zunino, Franco

“…Loss of p53 function has been linked to increased responsiveness to taxane treatment of ovarian carcinoma in clinical studies. We recently reported that the…”
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A novel taxane with improved tolerability and therapeutic activity in a panel of human tumor xenografts by POLIZZI, D, PRATESI, G, TORTORETO, M, SUPINO, R, RIVA, A, BOMBARDELLI, E, ZUNINO, F

“…Clinically available taxanes represent one of the most promising class of antitumor agents, despite several problems with their solubility and toxicity. In an…”
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Clavilactones, a novel class of tyrosine kinase inhibitors of fungal origin by Cassinelli, Giuliana, Lanzi, Cinzia, Pensa, Tiziana, Gambetta, Romolo A, Nasini, Gianluca, Cuccuru, Giuditta, Cassinis, Marco, Pratesi, Graziella, Polizzi, Donatella, Tortoreto, Monica, Zunino, Franco

“…Targeting of deregulated protein tyrosine kinases has been proposed as a new approach in the therapeutic intervention against pathological processes including…”
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Activation of the orphan nuclear receptor RORα induces growth arrest in androgen-independent DU 145 prostate cancer cells by Moretti, Roberta M., Marelli, Marina Montagnani, Motta, Marcella, Polizzi, Donatella, Monestiroli, Silvia, Pratesi, Graziella, Limonta, Patrizia

“…BACKGROUND RORα is a transcription factor which belongs to the family of orphan nuclear receptors. The regulatory functions of this receptor are still poorly…”
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Bcl-2 phosphorylation in a human breast carcinoma xenograft: a common event in response to effective DNA-damaging drugs by Pratesi, Graziella, Polizzi, Donatella, Perego, Paola, Dal Bo, Laura, Zunino, Franco

“…A variety of cytotoxic agents effective as antitumor drugs are known to kill tumor cells through induction of apoptosis as the most relevant modality of cell…”
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Doxorubicin disaccharide analogue : Apoptosis-related improvement of efficacy in vivo by ARCAMONE, F, ANIMATI, F, LOMBARDI, P, MADAMI, A, MANZINI, S, MONTEAGUDO, E, POLIZZI, D, PRATESI, G, RIGHETTI, S. C, SALVATORE, C, SUPINO, R, ZUNINO, F, BERETTONI, M, BIGIONI, M, CAPRANICO, G, CASAZZA, A. M, CASERINI, C, CIPOLLONE, A, DE CESARE, M, FRANCIOTTI, M

“…Although doxorubicin remains one of the most effective agents for the treatment of solid tumors, there is an intensive effort to synthesize doxorubicin…”
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Improved efficacy and enlarged spectrum of activity of a novel anthracycline disaccharide analogue of doxorubicin against human tumor xenografts by PRATESI, G, DE CESARE, M, SALVATORE, C, CASAZZA, A, ARCAMONE, F, ZUNINO, F, CASERINI, C, PEREGO, P, DAL BO, L, POLIZZI, D, SUPINO, R, BIGIONI, M, MANZINI, S, IAFRATE, E

“…On the basis of a structure-activity study of a new series of anthracycline disaccharides, we recently identified a doxorubicin analogue (MEN 10755) with a…”
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Activation of the orphan nuclear receptor ROR? induces growth arrest in androgen-independent DU 145 prostate cancer cells by Moretti, Roberta M., Marelli, Marina Montagnani, Motta, Marcella, Polizzi, Donatella, Monestiroli, Silvia, Pratesi, Graziella, Limonta, Patrizia

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Doxorubicin Disaccharide Analogue: Apoptosis-Related Improvement of Efficacy In Vivo by Arcamone, Federico, Animati, Fabio, Berettoni, Marco, Bigioni, Mario, Cipollone, Amalia, Franciotti, Maurizio, Lombardi, Paolo, Madami, Andrea, Manzini, Stefano, Salvatore, Carmela, Capranico, Giovanni, Caserini, Claudia, De Cesare, Michelandrea, Polizzi, Donatella, Pratesi, Graziella, Righetti, Sabina C., Supino, Rosanna, Zunino, Franco, Casazza, Anna Maria

“…Background: Although doxorubicin remains one of the most effective agents for the treatment of solid tumors, there is an intensive effort to synthesize…”
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