Search Results - "Politi, K."

EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer by Hastings, K., Yu, H.A., Wei, W., Sanchez-Vega, F., DeVeaux, M., Choi, J., Rizvi, H., Lisberg, A., Truini, A., Lydon, C.A., Liu, Z., Henick, B.S., Wurtz, A., Cai, G., Plodkowski, A.J., Long, N.M., Halpenny, D.F., Killam, J., Oliva, I., Schultz, N., Riely, G.J., Arcila, M.E., Ladanyi, M., Zelterman, D., Herbst, R.S., Goldberg, S.B., Awad, M.M., Garon, E.B., Gettinger, S., Hellmann, M.D., Politi, K.

“…Although EGFR mutant tumors exhibit low response rates to immune checkpoint blockade overall, some EGFR mutant tumors do respond to these therapies; however,…”
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A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers by Gettinger, S. N., Choi, J., Mani, N., Sanmamed, M. F., Datar, I., Sowell, Ryan, Du, Victor Y., Kaftan, E., Goldberg, S., Dong, W., Zelterman, D., Politi, K., Kavathas, P., Kaech, S., Yu, X., Zhao, H., Schlessinger, J., Lifton, R., Rimm, D. L., Chen, L., Herbst, R. S., Schalper, K. A.

“…The biological determinants of sensitivity and resistance to immune checkpoint blockers are not completely understood. To elucidate the role of intratumoral…”
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Evaluation of a risk score for interhospital transport of critically ill patients by Markakis, C, Dalezios, M, Chatzicostas, C, Chalkiadaki, A, Politi, K, Agouridakis, P J

“…Background: Interhospital transfer imposes essential risk for critically ill patients. The Risk Score for Transport Patients (RSTP) scale can be used as a…”
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P1555 Human herpes virus 6 infection in children in Northern Greece by Sidira, P, Mitka, S, Karabaxoglou, D, Politi, K, Kansouzidou, A, Papa, A

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Oncogenes come of age by Varmus, H, Pao, W, Politi, K, Podsypanina, K, Du, Y-C N

“…Mutations of proto-oncogenes are common events in the pathogenesis of cancers, as shown in a wide range of studies during the 30 years since the discovery of…”
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EGF Receptor Gene Mutations Are Common in Lung Cancers from "Never Smokers" and Are Associated with Sensitivity of Tumors to Gefitinib and Erlotinib by Pao, William, Miller, Vincent, Zakowski, Maureen, Doherty, Jennifer, Politi, Katerina, Sarkaria, Inderpal, Singh, Bhuvanesh, Heelan, Robert, Rusch, Valerie, Fulton, Lucinda, Mardis, Elaine, Kupfer, Doris, Wilson, Richard, Kris, Mark, Varmus, Harold

“…Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene are reportedly associated with sensitivity of lung…”
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Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance by Jia, Peilin, Jin, Hailing, Meador, Catherine B, Xia, Junfeng, Ohashi, Kadoaki, Liu, Lin, Pirazzoli, Valentina, Dahlman, Kimberly B, Politi, Katerina, Michor, Franziska, Zhao, Zhongming, Pao, William

“…Somatic mutations in kinase genes are associated with sensitivity of solid tumors to kinase inhibitors, but patients with metastatic cancer eventually develop…”
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Deconstructing tumor heterogeneity: the stromal perspective by Vickman, Renee E, Faget, Douglas V, Beachy, Philip, Beebe, David, Bhowmick, Neil A, Cukierman, Edna, Deng, Wu-Min, Granneman, James G, Hildesheim, Jeffrey, Kalluri, Raghu, Lau, Ken S, Lengyel, Ernst, Lundeberg, Joakim, Moscat, Jorge, Nelson, Peter S, Pietras, Kristian, Politi, Katerina, Puré, Ellen, Scherz-Shouval, Ruth, Sherman, Mara H, Tuveson, David, Weeraratna, Ashani T, White, Richard M, Wong, Melissa H, Woodhouse, Elisa C, Zheng, Ying, Hayward, Simon W, Stewart, Sheila A

“…Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression,…”
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Notch in mammary gland development and breast cancer by Politi, Katerina, Feirt, Nikki, Kitajewski, Jan

“…Notch signaling has been implicated in many processes including cell fate determination and oncogenesis. In mice, the Notch1 and Notch4 genes are both targets…”
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Assessing response to immunotherapy in patients with non-small cell lung cancer using circulating tumor DNA by Goldberg, S.B., Narayan, A., Kole, A.J., Decker, R.H., Teysir, J., Carriero, N.J., Lee, A., Nemati, R., Nath, S.K., Mane, S.M., Deng, Y., Sukumar, N., Zelterman, D., Boffa, D.J., Politi, K., Gettinger, S.N., Wilson, L.D., Herbst, R.S., Patel, A.A.

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Articular changes in experimentally induced patellar trauma by Triantafillopoulos, Ioannis K, Papagelopoulos, Panayiotis J, Politi, Panorea K, Nikiforidis, Panayiotis A

“…Only a few studies have described the microscopic pathology of the articular cartilage after trauma. In the present animal study, we demonstrate the effect of…”
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Bupivacaine-induced Regeneration of Rat Soleus Muscle: Ultrastructural and Immunohistochemical Aspects by Politi, Panorea K., Havaki, Sophia, Manta, Panagiota, Lyritis, George

“…The regeneration of soleus muscle injury induced by the bupivacaine model was studied ultrastructurally and immunohistochemically. Twenty-one young (age range…”
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Modulation of Notch Signaling Elicits Signature Tumors and Inhibits Hras1-Induced Oncogenesis in the Mouse Mammary Epithelium by Kiaris, Hippokratis, Politi, Katerina, Grimm, Lisa M., Szabolcs, Matthias, Fisher, Peter, Efstratiadis, Argiris, Artavanis-Tsakonas, Spyros

“…Deregulation of Notch signaling, which normally affects a broad spectrum of cell fates, has been implicated in various neoplastic conditions. Here we describe…”
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Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors by Trimis, George, Chatzistamou, Ioulia, Politi, Katerina, Kiaris, Hippokratis, Papavassiliou, Athanasios G.

“…During carcinogenesis, stromal fibroblasts undergo certain changes in concert with their neoplastic neighbors, an interaction that progressively leads to a…”
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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain by Pao, William, Miller, Vincent A, Politi, Katerina A, Riely, Gregory J, Somwar, Romel, Zakowski, Maureen F, Kris, Mark G, Varmus, Harold

“…Lung adenocarcinomas from patients who respond to the tyrosine kinase inhibitors gefitinib (Iressa) or erlotinib (Tarceva) usually harbor somatic…”
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A Mouse Model of Uterine Leiomyosarcoma by Politi, Katerina, Szabolcs, Matthias, Fisher, Peter, Kljuic, Ana, Ludwig, Thomas, Efstratiadis, Argiris

“…We are using an approach that is based on the cre/loxP recombination process and involves a binary system of Cre-producing and Cre-responding transgenic mice…”
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Defective phagocytic and bactericidal function of polymorphonuclear leucocytes in patients with beta-thalassaemia major by Skoutelis, A T, Lianou, E, Papavassiliou, T, Karamerou, A, Politi, K, Bassaris, H P

“…The phagocytic and bactericidal activity of polymorphonuclear leucocytes (PMNL) obtained from 50 non-splenectomised patients with homozygous beta-thalassaemia…”
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Expression of ERp29, an endoplasmic reticulum secretion factor in basal- cell carcinoma by CHERETIS, Christos, DIETRICH, Frank, CHATZISTAMOU, Ioulia, POLITI, Katerina, ANGELIDOU, Eirini, KIARIS, Hippokratis, MKRTCHIAN, Souren, KOUTSELINI, Helen

“…The role of endoplasmic reticulum (ER)-stress proteins in the pathogenesis of neoplasia remains obscure. ERp29 encodes for an ER protein that is thought to…”
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'Designer' tumors in mice by POLITI, Katerina, KLJUIC, Ana, SZABOLCS, Matthias, FISHER, Peter, LUDWIG, Thomas, EFSTRATIADIS, Argiris

“…We have developed and tested successfully a general method based on Cre-mediated recombination that can be used for ubiquitous or tissue-specific expression of…”
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Evaluation of Methods of Pre-Vaccination Screening for Markers of Hepatitis B Infection by Papaevangelou, G., Roumeliotou-Karayannis, A., Tassopoulos, N., Richardson, S. C., Stathopoulou, P., Papadoyannakis, N., Tsantoulis, N., Politi, K., Tassiopoulou, A.

“…The prevalence of serologic evidence of hepatitis B virus infection in various populations in Greece was examined to provide data for formulating…”
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