Search Results - "Polishook, Jon D."

Kibdelomycin Is a Potent and Selective Agent against Toxigenic Clostridium difficile by MIESEL, Lynn, HECHT, David W, LIU, Jenny, OLSEN, David B, SINGH, Sheo B, OSMOLSKI, James R, GERDING, Dale, FLATTERY, Amy, FANGBIAO LI, JING LAN, LIPARI, Philip, POLISHOOK, Jon D, LIANZHU LIANG

“…Clostridium difficile is the causative agent of C. difficile-associated diarrhea (CDAD), with increased risk in elderly populations. Kibdelomycin, a novel…”
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Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin by Ondeyka, John G, Smith, Scott K, Zink, Deborah L, Vicente, Francisca, Basilio, Angela, Bills, Gerald F, Polishook, Jon D, Garlisi, Charles, Mcguinness, Debra, Smith, Elizabeth, Qiu, Hongchen, Gill, Charles J, Donald, Robert GK, Phillips, John W, Goetz, Michael A, Singh, Sheo B

“…The ever-increasing bacterial resistance to clinical antibiotics is making many drugs ineffective and creating significant treatment gaps. This can be only…”
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Isolation, Structure Elucidation, and Biological Activity of Altersolanol P Using Staphylococcus aureus Fitness Test Based Genome-Wide Screening by Ondeyka, John, Buevich, Alexei V, Williamson, R. Thomas, Zink, Deborah L, Polishook, Jon D, Occi, James, Vicente, Francisca, Basilio, Angela, Bills, Gerald F, Donald, Robert G. K, Phillips, John W, Goetz, Michael A, Singh, Sheo B

“…Bacteria continue to evade existing antibiotics by acquiring resistance by various mechanisms, leading to loss of antibiotic effectiveness. To avoid an…”
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Isolation, Structure Elucidation, and Antibacterial Activity of Methiosetin, a Tetramic Acid from a Tropical Sooty Mold (Capnodium sp.) by Herath, Kithsiri, Jayasuriya, Hiranthi, Zink, Deborah L, Sigmund, Jan, Vicente, Francisca, de la Cruz, Mercedes, Basilio, Angela, Bills, Gerald F, Polishook, Jon D, Donald, Robert, Phillips, John, Goetz, Michael, Singh, Sheo B

“…Drug-resistant bacteria continue to make many existing antibiotic classes ineffective. In order to avoid a future epidemic from drug-resistant bacterial…”
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Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites by SINGH, Sheo B, JAYASURIYA, Hiranthi, FELOCK, Peter J, HAZUDA, Daria J, DEWEY, Raymond, POLISHOOK, Jon D, DOMBROWSKI, Anne W, ZINK, Deborah L, ZIQIANG GUAN, COLLADO, Javier, PLATAS, Gonzalo, PELAEZ, Fernando

“…HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition is one of the most promising new drug strategies for anti-retroviral therapy,…”
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Isolation and Structure of Antagonists of Chemokine Receptor (CCR5) by Jayasuriya, Hiranthi, Herath, Kithsiri B, Ondeyka, John G, Polishook, Jon D, Bills, Gerald F, Dombrowski, Anne W, Springer, Marty S, Siciliano, Sal, Malkowitz, Lorraine, Sanchez, Manuel, Guan, Ziqiang, Tiwari, Suroojnauth, Stevenson, Dennis W, Borris, Robert P, Singh, Sheo B

“…Human CCR5 is a G-coupled receptor that binds to the envelope protein gp120 and CD4 and mediates the HIV-1 viral entry into the cells. The blockade of this…”
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Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic Clostridioides difficile by Singh, Sheo B, Miesel, Lynn, Kramer, Susanne, Xu, Libo, Li, Fangbio, Lan, Jing, Lipari, Phillip, Polishook, Jon D, Liu, Gongjie, Liang, Lianzhu, Flattery, Amy M

“…Clostridioides difficile is a commensal Gram-positive gut bacterium that causes C. difficile-associated diarrhea. Currently available antibacterial therapeutic…”
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Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium Sp. Isolation, Structure Determination, and Chemical Transformations by Ondeyka, John G, Helms, Gregory L, Hensens, Otto D, Goetz, Michael A, Zink, Deborah L, Tsipouras, Athanasios, Shoop, Wesley L, Slayton, Lyndia, Dombrowski, Anne W, Polishook, Jon D, Ostlind, Dan A, Tsou, Nancy N, Ball, Richard G, Singh, Sheo B

“…The potent insecticidal agent nodulisporic acid A (1a), representative of a new class of indole terpenes, was isolated from fermentations of a Nodulisporium…”
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Isolation, Structure, and Coccidiostat Activity of Coccidiostatin A by Jayasuriya, Hiranthi, Guan, Ziqiang, Dombrowski, Anne W, Bills, Gerald F, Polishook, Jon D, Jenkins, Rosalind G, Koch, Leslie, Crumley, Tami, Tamas, Dubois, Michelle, Misura, Andrew, Darkin-Rattray, Sandra J, Gregory, Lynn, Singh, Sheo B

“…Coccidiosis is one of the more common and costly diseases in poultry that is caused by various Eimeria species. In our quest to discover coccidiostats from…”
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Identification of Diverse Microbial Metabolites as Potent Inhibitors of HIV-1 Tat Transactivation by Jayasuriya, Hiranthi, Zink, Deborah L., Polishook, Jon D., Bills, Gerald F., Dombrowski, Anne W., Genilloud, Olga, Pelaez, Fernando F., Herranz, Lucia, Quamina, Donette, Lingham, Russell B., Danzeizen, Renee, Graham, Pia L., Tomassini, Joanne E., Singh, Sheo B.

“…HIV‐1 Tat is one of six regulatory proteins that are required for viral replication and is an attractive target for the development of new anti‐HIV agents…”
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Isolation and Structures of Novel Fungal Metabolites as Chemokine Receptor (CCR2) Antagonists by Herath, Kithsiri B, Jayasuriya, Hiranthi, Ondeyka, John G, Polishook, Jon D, Bills, Gerald F, Dombrowski, Anne W, Cabello, Angeles, Vicario, Pasquale P, Zweerink, Hans, Guan, Ziqiang, Singh, Sheo B

“…The chemokine receptor, CCR2, is predominantly expressed on monocytes/macrophages, and on a subset of memory T cells. It binds to several CC type chemokines of…”
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Isolation, Structure, and HIV-1 Integrase Inhibitory Activity of Cytosporic Acid, a Fungal Metabolite Produced by a Cytospora sp by Jayasuriya, Hiranthi, Guan, Ziqiang, Polishook, Jon D, Dombrowski, Anne W, Felock, Peter J, Hazuda, Daria J, Singh, Sheo B

“…HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition has the potential to lead to an anti-retroviral therapy that has advantages…”
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Isolation, Structure, Absolute Stereochemistry, and HIV-1 Integrase Inhibitory Activity of Integrasone, a Novel Fungal Polyketide by Herath, Kithsiri B, Jayasuriya, Hiranthi, Bills, Gerald F, Polishook, Jon D, Dombrowski, Anne W, Guan, Ziqiang, Felock, Peter J, Hazuda, Daria J, Singh, Sheo B

“…HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition is one of the most promising new drug targets for anti-retroviral therapy with…”
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Isolation, structure and HIV-1 integrase inhibitory activity of exophillic acid, a novel fungal metabolite from Exophiala pisciphila by Ondeyka, John G, Zink, Deborah L, Dombrowski, Anne W, Polishook, Jon D, Felock, Peter J, Hazuda, Daria J, Singh, Sheo B

“…HIV-1 integrase is one of the three enzymes that are critical for replication and spread of HIV and its inhibition is one of the most promising new drug…”
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Apicidin: A Novel Antiprotozoal Agent that Inhibits Parasite Histone Deacetylase by Darkin-Rattray, Sandra J., Gurnett, Anne M., Myers, Robert W., Dulski, Paula M., Crumley, Tami M., Allocco, John J., Cannova, Christine, Meinke, Peter T., Colletti, Steven L., Bednarek, Maria A., Singh, Sheo B., Goetz, Michael A., Dombrowski, Anne W., Polishook, Jon D., Schmatz, Dennis M.

“…A novel fungal metabolite, apicidin [cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2- amino-8-oxodecanoyl)], that exhibits potent, broad…”
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Zaragozic Acids D and D2: Potent Inhibitors of Squalene Synthase and of Ras Farnesyl-Protein Transferase by Dufresne, Claude, Wilson, Kenneth E, Singh, Sheo Bux, Zink, Deborah L, Bergstrom, James D, Rew, Deborah, Polishook, Jon D, Meinz, Maria, Huang, Leeyuan, Silverman, Keith C, Lingham, Russell B, Mojena, Marina, Cascales, Carmen, Pelaéz, Fernando, Gibbs, Jackson B

“…Two new zaragozic acids, D and D2, have been isolated from the keratinophilic fungus Amauroascus niger. Zaragozic acids D [4] and D2 [5] are related to the…”
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Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase by Singh, Sheo B., Zink, Deborah L., Goetz, Michael A., Dombrowski, Anne W., Polishook, Jon D., Hazuda, Daria J.

“…Integration is an essential step in HIV replication and is catalyzed by an enzyme called integrase. We have isolated equisetin ( 1a), and a novel opposite…”
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Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase by Singh, Sheo B, Herath, Kithsiri, Guan, Ziqiang, Zink, Deborah L, Dombrowski, Anne W, Polishook, Jon D, Silverman, Keith C, Lingham, Russell B, Felock, Peter J, Hazuda, Daria J

“…[structure: see text]. Integramides A and B are two novel 16-mer linear peptides rich in C(alpha)-methyl amino acids that were isolated from fungal extracts of…”
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Citrafungins A and B, Two New Fungal Metabolite Inhibitors of GGTase I with Antifungal Activity by Singh, Sheo B, Zink, Deborah L, Doss, George A, Polishook, Jon D, Ruby, Carolyn, Register, Elizabeth, Kelly, Theresa M, Bonfiglio, Cynthia, Williamson, Joanne M, Kelly, Rosemarie

“…Screening of natural products extracts led to the discovery of citrafungins A and B, two new fungal metabolites of the alkylcitrate family that are inhibitors…”
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Integramides A and B, Two Novel Non-Ribosomal Linear Peptides Containing Nine C α-Methyl Amino Acids Produced by Fungal Fermentations That Are Inhibitors of HIV-1 Integrase by Singh, Sheo B, Herath, Kithsiri, Guan, Ziqiang, Zink, Deborah L, Dombrowski, Anne W, Polishook, Jon D, Silverman, Keith C, Lingham, Russell B, Felock, Peter J, Hazuda, Daria J

“…Integramides A and B are two novel 16-mer linear peptides rich in C α-methyl amino acids that were isolated from fungal extracts of Dendrodochium sp. by…”
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