Search Results - "Polidoro, Rafael B."

Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19 by Polidoro, Rafael B, Hagan, Robert S, de Santis Santiago, Roberta, Schmidt, Nathan W

“…Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some patients, lung infection leads to the activation of alveolar macrophages and…”
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Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions by Gutierrez-Arcelus, Maria, Teslovich, Nikola, Mola, Alex R., Polidoro, Rafael B., Nathan, Aparna, Kim, Hyun, Hannes, Susan, Slowikowski, Kamil, Watts, Gerald F. M., Korsunsky, Ilya, Brenner, Michael B., Raychaudhuri, Soumya, Brennan, Patrick J.

“…How innate T cells (ITC), including invariant natural killer T (iNKT) cells, mucosal-associated invariant T (MAIT) cells, and γδ T cells, maintain a poised…”
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Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection by Belew, A Trey, Junqueira, Caroline, Rodrigues-Luiz, Gabriela F, Valente, Bruna M, Oliveira, Antonio Edson R, Polidoro, Rafael B, Zuccherato, Luciana W, Bartholomeu, Daniella C, Schenkman, Sergio, Gazzinelli, Ricardo T, Burleigh, Barbara A, El-Sayed, Najib M, Teixeira, Santuza M R

“…Trypanosoma cruzi, the protozoan that causes Chagas disease, has a complex life cycle involving several morphologically and biochemically distinct stages that…”
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Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice by Garcia, Cristiana C, Russo, Remo C, Guabiraba, Rodrigo, Fagundes, Caio T, Polidoro, Rafael B, Tavares, Luciana P, Salgado, Ana Paula C, Cassali, Geovanni D, Sousa, Lirlândia P, Machado, Alexandre V, Teixeira, Mauro M

“…Influenza A virus causes annual epidemics which affect millions of people worldwide. A recent Influenza pandemic brought new awareness over the health impact…”
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Transient transfection and expression of foreign and endogenous genes in the intracellular stages of Trypanosoma cruzi by Padmanabhan, Prasad K., Polidoro, Rafael B., Barteneva, Natasha S., Gazzinelli, Ricardo T., Burleigh, Barbara A.

“…•A rapid method for transgene expression in intracellular T. cruzi amastigotes.•Direct transfection of trypomastigotes prior to host cell infection.•FACS…”
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γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis by Junqueira, Caroline, Polidoro, Rafael B., Castro, Guilherme, Absalon, Sabrina, Liang, Zhitao, Sen Santara, Sumit, Crespo, Ângela, Pereira, Dhelio B., Gazzinelli, Ricardo T., Dvorin, Jeffrey D., Lieberman, Judy

“…Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are expanded in Plasmodium falciparum– infected patients. Although previous…”
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Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites by Dotiwala, Farokh, Mulik, Sachin, Polidoro, Rafael B, Ansara, James A, Burleigh, Barbara A, Walch, Michael, Gazzinelli, Ricardo T, Lieberman, Judy

“…Judy Lieberman and colleagues show that intracellular parasites are eradicated by lymphocyte delivery of cytotoxic granule contents—perforin, granulysin and…”
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Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine by Senkpeil, Leetah, Bhardwaj, Jyoti, Little, Morgan R, Holla, Prasida, Upadhye, Aditi, Fusco, Elizabeth M, Swanson, 2nd, Phillip A, Wiegand, Ryan E, Macklin, Michael D, Bi, Kevin, Flynn, Barbara J, Yamamoto, Ayako, Gaskin, Erik L, Sather, D Noah, Oblak, Adrian L, Simpson, Edward, Gao, Hongyu, Haining, W Nicholas, Yates, Kathleen B, Liu, Xiaowen, Murshedkar, Tooba, Richie, Thomas L, Sim, B Kim Lee, Otieno, Kephas, Kariuki, Simon, Xuei, Xiaoling, Liu, Yunlong, Polidoro, Rafael B, Hoffman, Stephen L, Oneko, Martina, Steinhardt, Laura C, Schmidt, Nathan W, Seder, Robert A, Tran, Tuan M

“…A systems analysis was conducted to determine the potential molecular mechanisms underlying differential immunogenicity and protective efficacy results of a…”
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[delta] T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis by Junqueira, Caroline, Polidoro, Rafael B, Castro, Guilherme, Absalon, Sabrina, Liang, Zhitao, Sen Santara, Sumit, Crespo, Ângela

“…Activated V[gamma]9V[delta]2 ([gamma][delta]2) T lymphocytes that sense parasite-produced phosphoantigens are expanded in Plasmodium falciparum-infected…”
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IRF3 inhibits IFNγ-mediated restriction of intracellular pathogens in macrophages independently of type I interferons by Maciag, Karolina, Raychowdhury, Raktima, Smith, Karen, Coers, Jörn, Mumbach, Maxwell R., Schwartz, Schraga, Polidoro, Rafael B., Gazzinelli, Ricardo, Hacohen, Nir

“…Abstract Macrophages use an array of innate immune sensors to detect intracellular pathogens and to tailor effective antimicrobial responses. In addition,…”
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Pathogenic effector TH2 lymphocytes in human nasal polyposis by Tuttle, Katherine L., Mola, Alex R., Dwyer, Daniel F., Polidoro, Rafael B., Barrett, Nora A., Boyce, Joshua A., Brennan, Patrick J.

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Pathogenic effector T H 2 lymphocytes in human nasal polyposis by Tuttle, Katherine L, Mola, Alex R, Dwyer, Daniel F, Polidoro, Rafael B, Barrett, Nora A, Boyce, Joshua A, Brennan, Patrick J

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Platelet-Activating Factor Receptor Plays a Role in Lung Injury and Death Caused by Influenza A in Mice: e1001171 by Garcia, Cristiana C, Russo, Remo C, Guabiraba, Rodrigo, Fagundes, Caio T, Polidoro, Rafael B, Tavares, Luciana P, Salgado, Ana PaulaC, Cassali, Geovanni D, Sousa, Lirlândia P, Machado, Alexandre V, Teixeira, Mauro M

“…Influenza A virus causes annual epidemics which affect millions of people worldwide. A recent Influenza pandemic brought new awareness over the health impact…”
Get full text