Search Results - "Polard, Patrice"

Bacterial transformation: distribution, shared mechanisms and divergent control by Johnston, Calum, Martin, Bernard, Fichant, Gwennaele, Polard, Patrice, Claverys, Jean-Pierre

“…Key Points This Review discusses natural bacterial transformation, highlighting the common and divergent features that exist in a phylogenetically diverse…”
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Fever-like temperature bursts promote competence development via an HtrA-dependent pathway in Streptococcus pneumoniae by Maziero, Mickaël, Lane, David, Polard, Patrice, Bergé, Mathieu

“…Streptococcus pneumoniae (the pneumococcus) is well known for its ability to develop competence for natural DNA transformation. Competence development is…”
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genetic transformation machinery: composition, localization, and mechanism by Claverys, Jean-Pierre, Martin, Bernard, Polard, Patrice

“…Natural genetic transformation is widely distributed in bacteria. It is a genetically programmed process that is inherent to the species. Transformation…”
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A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae by Bergé, Matthieu J., Mercy, Chryslène, Mortier-Barrière, Isabelle, VanNieuwenhze, Michael S., Brun, Yves V., Grangeasse, Christophe, Polard, Patrice, Campo, Nathalie

“…Competence for genetic transformation is a differentiation program during which exogenous DNA is imported into the cell and integrated into the chromosome. In…”
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The C-terminal domain of the bacterial SSB protein acts as a DNA maintenance hub at active chromosome replication forks by Costes, Audrey, Lecointe, François, McGovern, Stephen, Quevillon-Cheruel, Sophie, Polard, Patrice

“…We have investigated in vivo the role of the carboxy-terminal domain of the Bacillus subtilis Single-Stranded DNA Binding protein (SSB(Cter)) as a recruitment…”
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Induction of competence for genetic transformation by antibiotics: convergent evolution of stress responses in distant bacterial species lacking SOS? by Charpentier, Xavier, Polard, Patrice, Claverys, Jean-Pierre

“…Highlights ► SOS-inducing antibiotics induce natural competence in non-SOS bacterial species. ► Competence regulatory circuits are diverse, yet they are…”
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Pneumococcal Competence Coordination Relies on a Cell-Contact Sensing Mechanism by Prudhomme, Marc, Berge, Mathieu, Martin, Bernard, Polard, Patrice

“…Bacteria have evolved various inducible genetic programs to face many types of stress that challenge their growth and survival. Competence is one such program…”
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Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence by Mirouze, Nicolas, Bergé, Mathieu A, Soulet, Anne-Lise, Mortier-Barrière, Isabelle, Quentin, Yves, Fichant, Gwennaele, Granadel, Chantal, Noirot-Gros, Marie-Françoise, Noirot, Philippe, Polard, Patrice, Martin, Bernard, Claverys, Jean-Pierre

“…Natural bacterial transformation is a genetically programmed process allowing genotype alterations that involves the internalization of DNA and its chromosomal…”
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Fine‐tuning cellular levels of DprA ensures transformant fitness in the human pathogen Streptococcus pneumoniae by Johnston, Calum, Mortier‐Barriere, Isabelle, Khemici, Vanessa, Polard, Patrice

“…Summary Natural genetic transformation is a widespread mechanism of horizontal gene transfer. It involves the internalization of exogenous DNA as single…”
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Pneumococcal competence is a populational health sensor driving multilevel heterogeneity in response to antibiotics by Prudhomme, Marc, Johnston, Calum H. G., Soulet, Anne-Lise, Boyeldieu, Anne, De Lemos, David, Campo, Nathalie, Polard, Patrice

“…Competence for natural transformation is a central driver of genetic diversity in bacteria. In the human pathogen Streptococcus pneumoniae , competence…”
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Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension by Marie, Léa, Rapisarda, Chiara, Morales, Violette, Bergé, Mathieu, Perry, Thomas, Soulet, Anne-Lise, Gruget, Clémence, Remaut, Han, Fronzes, Rémi, Polard, Patrice

“…Homologous recombination (HR) is a central process of genome biology driven by a conserved recombinase, which catalyses the pairing of single-stranded DNA…”
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Streptococcus pneumoniae , le transformiste by Johnston, Calum, Campo, Nathalie, Bergé, Matthieu J, Polard, Patrice, Claverys, Jean-Pierre

“…Highlights • Bacterial genetic transformation, which was discovered in Streptococcus pneumoniae , is widespread. • Transformation allows horizontal gene…”
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The ex planta signal activity of a Medicago ribosomal uL2 protein suggests a moonlighting role in controlling secondary rhizobial infection by Sorroche, Fernando, Morales, Violette, Mouffok, Saïda, Pichereaux, Carole, Garnerone, A. Marie, Zou, Lan, Soni, Badrish, Carpéné, Marie-Anne, Gargaros, Audrey, Maillet, Fabienne, Burlet-Schiltz, Odile, Poinsot, Verena, Polard, Patrice, Gough, Clare, Batut, Jacques, Martinez-Abarca, Francisco

“…We recently described a regulatory loop, which we termed autoregulation of infection (AOI), by which Sinorhizobium meliloti, a Medicago endosymbiont,…”
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Midcell recruitment of the DNA uptake and virulence nuclease, EndA, for pneumococcal transformation by Bergé, Matthieu J, Kamgoué, Alain, Martin, Bernard, Polard, Patrice, Campo, Nathalie, Claverys, Jean-Pierre

“…Genetic transformation, in which cells internalize exogenous DNA and integrate it into their chromosome, is widespread in the bacterial kingdom. It involves a…”
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Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events by Kurushima, Jun, Campo, Nathalie, van Raaphorst, Renske, Cerckel, Guillaume, Polard, Patrice, Veening, Jan-Willem

“…The spread of antimicrobial resistance and vaccine escape in the human pathogen can be largely attributed to competence-induced transformation. Here, we…”
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Tight Interplay between Replication Stress and Competence Induction in Streptococcus pneumoniae by Khemici, Vanessa, Prudhomme, Marc, Polard, Patrice

“…Cells respond to genome damage by inducing restorative programs, typified by the SOS response of Escherichia coli. Streptococcus pneumoniae (the pneumococcus),…”
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Dynamic Modeling of Streptococcus pneumoniae Competence Provides Regulatory Mechanistic Insights Into Its Tight Temporal Regulation by Weyder, Mathias, Prudhomme, Marc, Bergé, Mathieu, Polard, Patrice, Fichant, Gwennaele

“…In the human pathogen , the gene regulatory circuit leading to the transient state of competence for natural transformation is based on production of an…”
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ComE/ComE similar to P interplay dictates activation or extinction status of pneumococcal X-state (competence) by Martin, Bernard, Soulet, Anne-Lise, Mirouze, Nicolas, Prudhomme, Marc, Mortier-Barriere, Isabelle, Granadel, Chantal, Noirot-Gros, Marie-Francoise, Noirot, Philippe, Polard, Patrice, Claverys, Jean-Pierre

“…Since 1996, induction of competence for genetic transformation of Streptococcus pneumoniaeis known to be controlled by the ComD/ComEtwo-component regulatory…”
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ComE/ComE∼P interplay dictates activation or extinction status of pneumococcal X‐state (competence) by Martin, Bernard, Soulet, Anne‐Lise, Mirouze, Nicolas, Prudhomme, Marc, Mortier‐Barrière, Isabelle, Granadel, Chantal, Noirot‐Gros, Marie‐Françoise, Noirot, Philippe, Polard, Patrice, Claverys, Jean‐Pierre

“…Summary Since 1996, induction of competence for genetic transformation of Streptococcus pneumoniae is known to be controlled by the ComD/ComE two‐component…”
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Structure–function analysis of pneumococcal DprA protein reveals that dimerization is crucial for loading RecA recombinase onto DNA during transformation by Quevillon-Cheruel, Sophie, Campo, Nathalie, Mirouze, Nicolas, Mortier-Barrière, Isabelle, Brooks, Mark A, Boudes, Marion, Durand, Dominique, Soulet, Anne-Lise, Lisboa, Johnny, Noirot, Philippe, Martin, Bernard, van Tilbeurgh, Herman, Noirot-Gros, Marie-Françoise, Claverys, Jean-Pierre, Polard, Patrice

“…Transformation promotes genome plasticity in bacteria via RecA-driven homologous recombination. In the Gram-positive human pathogen Streptococcus pneumoniae ,…”
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