Search Results - "Polak, Timothy"

Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15 by Freeman, Christine M, Han, MeiLan K, Martinez, Fernando J, Murray, Susan, Liu, Lyrica X, Chensue, Stephen W, Polak, Timothy J, Sonstein, Joanne, Todt, Jill C, Ames, Theresa M, Arenberg, Douglas A, Meldrum, Catherine A, Getty, Christi, McCloskey, Lisa, Curtis, Jeffrey L

“…Lung CD8(+) T cells might contribute to progression of chronic obstructive pulmonary disease (COPD) indirectly via IFN-gamma production or directly via…”
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Resident Murine Alveolar and Peritoneal Macrophages Differ in Adhesion of Apoptotic Thymocytes by Hu, Bin, Jennings, Jeffrey H, Sonstein, Joanne, Floros, Joanna, Todt, Jill C, Polak, Timothy, Curtis, Jeffrey L

“…Apoptotic cells must be cleared efficiently by macrophages (Mø) to prevent autoimmunity, yet their ingestion impairs Mø microbicidal function. The principal…”
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Recognition and phagocytosis of apoptotic T cells by resident murine tissue macrophages require multiple signal transduction events by Hu, Bin, Punturieri, Antonello, Todt, Jill, Sonstein, Joanne, Polak, Timothy, Curtis, Jeffrey L.

“…Macrophages (Mø) ingest apoptotic cells with unique effects on their cytokine production, but the signaling pathways involved are virtually unknown. Signal…”
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CCR2 Mediates Conventional Dendritic Cell Recruitment and the Formation of Bronchovascular Mononuclear Cell Infiltrates in the Lungs of Mice Infected with Cryptococcus neoformans by Osterholzer, John J, Curtis, Jeffrey L, Polak, Timothy, Ames, Theresa, Chen, Gwo-Hsiao, McDonald, Rod, Huffnagle, Gary B, Toews, Galen B

“…Pulmonary clearance of the encapsulated yeast Cryptococcus neoformans requires the development of T1-type immunity. CCR2-deficient mice infected with C…”
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CCR2 and CCR6, but Not Endothelial Selectins, Mediate the Accumulation of Immature Dendritic Cells within the Lungs of Mice in Response to Particulate Antigen by Osterholzer, John J, Ames, Theresa, Polak, Timothy, Sonstein, Joanne, Moore, Bethany B, Chensue, Stephen W, Toews, Galen B, Curtis, Jeffrey L

“…Dendritic cells (DC) migrate from sites of inflammation to lymph nodes to initiate primary immune responses, but the molecular mechanisms by which DC are…”
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Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages by Punturieri, Antonello, Alviani, Rebecca S, Polak, Timothy, Copper, Phil, Sonstein, Joanne, Curtis, Jeffrey L

“…The innate immune response must be mobilized promptly yet judiciously via TLRs to protect the lungs against pathogens. Stimulation of murine peritoneal…”
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Conserved Nontypeable Haemophilus influenzae-Derived TLR2-Binding Lipopeptides Synergize with IFN-beta to Increase Cytokine Production by Resident Murine and Human Alveolar Macrophages by Punturieri, Antonello, Copper, Phil, Polak, Timothy, Christensen, Paul J, Curtis, Jeffrey L

“…Nontypeable Haemophilus influenzae (NTHi) is strongly associated with exacerbations of chronic obstructive pulmonary disease, which often coincide with viral…”
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Cytotoxic potential of lung CD8+ T cells increases with COPD severity and with in vitro stimulation by IL-18 or IL-15 by Freeman, Christine M., Han, MeiLan K., Martinez, Fernando J., Murray, Susan, Liu, Lyrica X., Chensue, Stephen W., Polak, Timothy J., Sonstein, Joanne, Todt, Jill C., Ames, Theresa M., Arenberg, Douglas A., Meldrum, Catherine A., Getty, Christi, McCloskey, Lisa, Curtis, Jeffrey L.

“…Lung CD8+ T cells might contribute to progression of chronic obstructive pulmonary disease (COPD) indirectly via IFN-γ production or directly via cytolysis but…”
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Conserved Nontypeable Haemophilus influenzae-Derived TLR2-Binding Lipopeptides Synergize with IFN-β to Increase Cytokine Production by Resident Murine and Human Alveolar Macrophages1 by Punturieri, Antonello, Copper, Phil, Polak, Timothy, Christensen, Paul J., Curtis, Jeffrey L.

“…Nontypeable Haemophilus influenzae (NTHi) is strongly associated with exacerbations of chronic obstructive pulmonary disease, which often coincide with viral…”
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Activation of Protein Kinase C βII by the Stereo-specific Phosphatidylserine Receptor Is Required for Phagocytosis of Apoptotic Thymocytes by Resident Murine Tissue Macrophages by Todt, Jill C., Hu, Bin, Punturieri, Antonello, Sonstein, Joanne, Polak, Timothy, Curtis, Jeffrey L.

“…We showed previously that protein kinase C (PKC) is required for phagocytosis of apoptotic leukocytes by murine alveolar (AMø) and peritoneal macrophages (PMø)…”
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Specific engagement of TLR4 or TLR3 does not lead to IFN-β-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages1 by Punturieri, Antonello, Alviani, Rebecca S., Polak, Timothy, Copper, Phil, Sonstein, Joanne, Curtis, Jeffrey L.

“…The innate immune response must be mobilized promptly yet judiciously via Toll-like receptors (TLRs) to protect the lungs against pathogens. Stimulation of…”
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Cutting Edge: Antigen-Driven Lymphocyte Recruitment to the Lung Is Diminished in the Absence of Urokinase-Type Plasminogen Activator (uPA) Receptor, but Is Independent of uPA by Gyetko, Margaret R, Sud, Sudha, Sonstein, Joanne, Polak, Timothy, Sud, Anchal, Curtis, Jeffrey L

“…Abstract The requirement for urokinase plasminogen activator (uPA) and uPA receptor (uPAR) in T lymphocyte migration is unknown. uPA−/− mice have fewer…”
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CCR2 and CCR6, but Not Endothelial Selectins, Mediate the Accumulation of Immature Dendritic Cells within the Lungs of Mice in Response to Particulate Antigen12 by Osterholzer, John J., Ames, Theresa, Polak, Timothy, Sonstein, Joanne, Moore, Bethany B., Chensue, Stephen W., Toews, Galen B., Curtis, Jeffrey L.

“…Dendritic cells (DC) migrate from sites of inflammation to lymph nodes to initiate primary immune responses, but the molecular mechanisms by which DC are…”
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Activation of Protein Kinase C βII by the Stereo-specific Phosphatidylserine Receptor Is Required for Phagocytosis of Apoptotic Thymocytes by Resident Murine Tissue Macrophages by Jill C. Todt, Bin Hu, Antonello Punturieri, Joanne Sonstein, Timothy Polak, Jeffrey L. Curtis

“…We showed previously that protein kinase C (PKC) is required for phagocytosis of apoptotic leukocytes by murine alveolar (AMø) and peritoneal macrophages…”
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Activation of Protein Kinase C βII by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages3 by Todt, Jill C., Hu, Bin, Punturieri, Antonello, Sonstein, Joanne, Polak, Timothy, Curtis, Jeffrey L.

“…We showed previously that protein kinase C (PKC) is required for phagocytosis of apoptotic leukocytes by murine alveolar (AMø) and peritoneal macrophages…”
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RECOGNITION AND PHAGOCYTOSIS OF APOPTOTIC T CELLS BY RESIDENT MURINE TISSUE MACROPHAGES REQUIRES MULTIPLE SIGNAL TRANSDUCTION EVENTS by Hu, Bin, Punturieri, Antonello, Todt, Jill, Sonstein, Joanne, Polak, Timothy, Curtis, Jeffrey L.

“…Macrophages (Mø) ingest apoptotic cells with unique effects on their cytokine production, but the signaling pathways involved are virtually unknown. Signal…”
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Subset-Specific Reductions in Lung Lymphocyte Accumulation Following Intratracheal Antigen Challenge in Endothelial Selectin-Deficient Mice by Curtis, Jeffrey L, Sonstein, Joanne, Craig, Ronald A, Todt, Jill C, Knibbs, Randall N, Polak, Timothy, Bullard, Daniel C, Stoolman3, Lloyd M

“…We previously demonstrated induction and expression of CD62E and CD62P in the lungs of mice primed and then challenged with intratracheal (i.t.) SRBC. The…”
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Repeated intratracheal challenge with particulate antigen modulates murine lung cytokines by Todt, J, Sonstein, J, Polak, T, Seitzman, G D, Hu, B, Curtis, J L

“…When lungs of experimental animals are repeatedly challenged with Ag, pulmonary inflammation wanes via unknown mechanisms. We hypothesized that changes in the…”
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Specific Engagement of TLR4 or TLR3 Does Not Lead to IFN-{beta}-Mediated Innate Signal Amplification and STAT1 Phosphorylation in Resident Murine Alveolar Macrophages by Punturieri, Antonello, Alviani, Rebecca S, Polak, Timothy, Copper, Phil, Sonstein, Joanne, Curtis, Jeffrey L

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Lymphocyte–endothelial cell adhesive interactions in lung immunity: lessons from the murine response to particulate antigen by Curtis, Jeffrey L, Wolber, Frances M, Sonstein, Joanne, Craig, Ronald A, Polak, Timothy, Knibbs, Randall N, Todt, Jill, Seitzman, Gerami D, Stoolman, Lloyd M

“…The adhesive interaction between lymphocytes and lung endothelial cells presents an attractive arena for the development of novel therapeutic agents to modify…”
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