Search Results - "Polak, MM"

Multiple hyperplastic polyps in the stomach: Evidence for clonality and neoplastic potential by Dijkhuizen, SM, Entius, MM, Clement, MJ, Polak, MM, Van den Berg, FM, Craanen, ME, Slebos, RJ, Offerhaus, GJ

“…The origin and neoplastic potential of gastric epithelial polyps remains an area of great interest, and treatment choices are a topic of controversy. This…”
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Detection of p53 overexpression in routinely paraffin-embedded tissue of human carcinomas using a novel target unmasking fluid by van den Berg, FM, Baas, IO, Polak, MM, Offerhaus, GJ

“…With the aid of a newly developed target unmasking fluid (TUF), p53 overexpression was visualized by immunohistochemistry on recent and archival…”
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Diagnostic p53 Immunostaining of Endobiliary brush cytology : Preoperative cytology compared with the surgical specimen by TASCILAR, M, STURM, P. D. J, CASPERS, E, SMIT, M, POLAK, M. M, HUIBREGTSE, K, NOORDUYN, L. A, OFFERHAUS, G. J. A

“…Endobiliary brush cytology is important in the distinction of malignant and benign causes of extrahepatic bile duct obstruction. The additional diagnostic…”
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Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma by MULDER, J-W. R, BAAS, I. O, POLAK, M. M, GOODMAN, S. N, OFFERHAUS, G. J. A

“…Mutation of the p53 gene is reported to be of prognostic importance in colorectal carcinomas. Immunohistochemical staining of the accumulated p53 gene product…”
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Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis by Mulder, J W, Wielenga, V J, Polak, M M, van den Berg, F M, Adolf, G R, Herrlich, P, Pals, S T, Offerhaus, G J

“…Colorectal tumorigenesis evolves through a series of molecular genetic changes, providing putative markers for tumour progression. This study investigated the…”
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Clinical significance of K-ras oncogene activation in ampullary neoplasms by Chung, C H, Wilentz, R E, Polak, M M, Ramsoekh, T B, Noorduyn, L A, Gouma, D J, Huibregtse, K, Offerhaus, G J, Slebos, R J

“…AIMS: To investigate the prevalence of K-ras codon 12 point mutations in ampullary neoplasms, to explore their clinical usefulness, and to test whether the…”
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Molecular evidence of field cancerization in a patient with 7 tumors of the aerodigestive tract by van Rees, Bastiaan P., Cleton-Jansen, Anne-Marie, Cense, Huib A., Polak, Mirjam M., Clement, Marjon J., Drillenburg, Paul, van Lanschot, Jan J.B., Offerhaus, G. Johan A.

“…Exposure of the mucosa of the upper aerodigestive tract to carcinogens can induce genetic changes resulting in various independent clones of neoplastic growth,…”
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Diagnostic and prognostic value of incidence of k-ras codon 12 mutations in resected distal bile duct carcinoma by Rijken, Arjen M., Van Gulik, Thomas M., Polak, Mirjam M., Sturm, Patrick D. J., Gouma, Dirk J., Offerhaus, G. Johan A.

“…Background and Objectives: The K‐ras gene is one of the most extensively investigated oncogenes in a wide variety of human tumors, but has rarely been studied…”
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Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma by Rijken, A M, Umezawa, A, van Gulik, T M, Bosma, A, Polak, M M, Offerhaus, G J, Obertop, H, Gouma, D J

“…The aim of this study was to investigate the prognostic value of cell proliferation (Ki-67 antigen) and DNA content in patients resected for distal bile duct…”
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Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product by van Es, J M, Polak, M M, van den Berg, F M, Ramsoekh, T B, Craanen, M E, Hruban, R H, Offerhaus, G J

“…AIMS--To determine the potential efficiency of molecular markers specific for neoplastic change--mutations of the K-ras oncogene and the p53 tumour suppressor…”
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p53 expression as a prognostic determinant in resected distal bile duct carcinoma by Rijken, A.M., Offerhaus, G.J.A., Polak, M.M., Gouma, D.J., van Gulik, T.M.

“…AimsTo determine the incidence and prognostic value of p53 immunopositivity in resectable distal bile duct carcinoma (DBDC).MethodsForty-seven…”
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Peutz-Jeghers polyps, dysplasia, and K-ras codon 12 mutations by Entius, M M, Westerman, A M, Giardiello, F M, van Velthuysen, M-L F, Polak, M M, Slebos, R J C, Wilson, J H P, Hamilton, S R, Offerhaus, G J A

“…Background—Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant, polyposis syndrome, associated with an increased risk of gastrointestinal and…”
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Mutational analysis of the P16-binding domain of cyclin-dependent kinase 4 in tumors in the head region of the pancreas by CEHA, H. M, CLEMENT, M. J, POLAK, M. M, OFFERHAUS, G. J. A, SLEBOS, R. J. C

“…Alterations in genes involved in cell cycle regulation are common in many tumor types. In pancreatic adenocarcinomas, inactivating mutations in the CDKN2 gene,…”
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DNA quantitation of distal bile duct carcinoma measured by image and flow cytometry by Rijken, A M, Belien, J A, van Gulik, T M, Polak, M M, Offerhaus, G J, Gouma, D J, Baak, J P

“…To evaluate discrepancies between flow cytometry (FCM) and image cytometry (ICM), ploidy incidence and relation between DNA ploidies and survival in distal…”
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