Search Results - "Polášek, M."

Calculation of the pharmacogenomics benefit score for patients with medication-related problems by Polasek, Thomas M

“…Unexpected poor efficacy and intolerable adverse effects are medication-related problems that may result from genetic variation in genes encoding key proteins…”
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Sequential injection technique applied to pharmaceutical analysis by Solich, P, Polášek, M, Klimundová, J, Ruzicka, J

“…The versatility of sequential injection analysis (SIA), based on programmable flow, has been recently enhanced by the miniaturization implemented in…”
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Virtual Twins: Understanding the Data Required for Model‐Informed Precision Dosing by Polasek, Thomas M., Rostami‐Hodjegan, Amin

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Contrasting Dynamics in Isoelectronic Anions Formed by Electron Attachment by Nag, P., Ranković, M., Polášek, M., Čurík, R., Slaughter, D. S., Fedor, J.

“…Cyanogen NCCN and cyanoacetylene HCCCN are isoelectronic molecules, and as such, they have many similar properties. We focus on the bond cleavage in these…”
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The reactivity of methanimine radical cation (H2CNH•+) and its isomer aminomethylene (HCNH2•+) with C2H4 by Sundelin, D., Ascenzi, D., Richardson, V., Alcaraz, C., Polášek, M., Romanzin, C., Thissen, R., Tosi, P., Žabka, J., Geppert, W.

“…[Display omitted] •Cationic isomers of methanimine generated via dissociative photoionization.•Reactive cross sections and branching ratios with C2H4 as a…”
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Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy by Darwich, Adam S, Polasek, Thomas M, Aronson, Jeffrey K, Ogungbenro, Kayode, Wright, Daniel F.B, Achour, Brahim, Reny, Jean-Luc, Daali, Youssef, Eiermann, Birgit, Cook, Jack, Lesko, Lawrence, McLachlan, Andrew J, Rostami-Hodjegan, Amin

“…Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in which the characteristics of each…”
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The reactivity of methanimine radical cation (H2CNH+) and its isomer aminomethylene (HCNH2+) with methane by Richardson, V., Alcaraz, C., Geppert, W.D., Polášek, M., Romanzin, C., Sundelin, D., Thissen, R., Tosi, P., Žabka, J., Ascenzi, D.

“…[Display omitted] •Cationic isomers of methanimine generated via dissociative photoionization.•Isomers react with methane by H atom transfer to give protonated…”
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Virtual twin for healthcare management by Polasek, Thomas M.

“…Healthcare is increasingly fragmented, resulting in escalating costs, patient dissatisfaction, and sometimes adverse clinical outcomes. Strategies to decrease…”
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Personality vulnerabilities and adverse event reporting in phase 1 clinical studies by Skommer, Joanna, Gunesh, Krish, Polasek, Thomas M

“…Phase 1 clinical trials involve rigorous safety monitoring to identify any adverse effects of investigational treatments. There is growing evidence that…”
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Improving the Efficiency of Clinical Pharmacology Studies by Polasek, Thomas M., Schuck, Virna

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Quantifying the Impact of Phenoconversion on Medications With Actionable Pharmacogenomic Guideline Recommendations in an Acute Aged Persons Mental Health Setting by Mostafa, Sam, Polasek, Thomas M., Sheffield, Leslie J., Huppert, David, Kirkpatrick, Carl M. J.

“…Introduction: Polypharmacy and genetic variants that strongly influence medication response (pharmacogenomics, PGx) are two well-described risk factors for…”
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A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers by Kenney, Richard T, Cini, John K, Dexter, Susan, DaFonseca, Manuel, Bingham, Justus, Kuan, Isabelle, Chawla, Sant P, Polasek, Thomas M, Lickliter, Jason, Ryan, Philip J

“…The benefits of recombinant interleukin-12 (rIL-12) as a multifunctional cytokine and potential immunotherapy for cancer have been sought for decades based on…”
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Artificial Intelligence and Machine Learning Applied at the Point of Care by Angehrn, Zuzanna, Haldna, Liina, Zandvliet, Anthe S, Gil Berglund, Eva, Zeeuw, Joost, Amzal, Billy, Cheung, S Y Amy, Polasek, Thomas M, Pfister, Marc, Kerbusch, Thomas, Heckman, Niedre M

“…The increasing availability of healthcare data and rapid development of big data analytic methods has opened new avenues for use of Artificial Intelligence…”
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In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism by Korprasertthaworn, Porntipa, Polasek, Thomas M, Sorich, Michael J, McLachlan, Andrew J, Miners, John O, Tucker, Geoffrey T, Rowland, Andrew

“…Olanzapine (OLZ) is an atypical antipsychotic used in the treatment of schizophrenia and related psychoses. The metabolism of OLZ is complex and incompletely…”
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Efficacy and safety of pharmacogenomic-guided antidepressant prescribing in patients with depression: an umbrella review and updated meta-analysis by Tesfamicael, Kiflu G, Zhao, Lijun, Fernández-Rodríguez, Rubén, Adelson, David L, Musker, Michael, Polasek, Thomas M, Lewis, Martin David

“…To determine the efficacy and safety of pharmacogenomics (PGx)-guided antidepressant prescribing in patients with depression through an umbrella review and…”
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Delineating gene–environment effects using virtual twins of patients treated with clozapine by Mostafa, Sam, Polasek, Thomas M., Bousman, Chad, Rostami‐Hodjegan, Amin, Sheffield, Leslie J., Everall, Ian, Pantelis, Christos, Kirkpatrick, Carl M. J.

“…Studies that focus on individual covariates, while ignoring their interactions, may not be adequate for model‐informed precision dosing (MIPD) in any given…”
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Determination of bopindolol in pharmaceuticals by capillary isotachophoresis by URBANEK, M, POSPISILOVA, M, POLASEK, M

“…Capillary isotachophoresis (ITP) with conductimetric detection has been used for separating and determining bopindolol ( I) in commercial mass-produced…”
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Pharmacogenomics in general practice: The time has come by Polasek, Thomas M, Mina, Kym, Suthers, Graeme

“…Patients respond to medications differently because of variations in the genes that determine medication exposure and medication response. The aim of this…”
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Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia by Mostafa, Sam, Rafizadeh, Reza, Polasek, Thomas M., Bousman, Chad A., Rostami‐Hodjegan, Amin, Stowe, Robert, Carrion, Prescilla, Sheffield, Leslie J., Kirkpatrick, Carl M. J.

“…Model‐informed precision dosing using virtual twins (MIPD‐VTs) is an emerging strategy to predict target drug concentrations in clinical practice. Using a high…”
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Combining Therapeutic Drug Monitoring and Pharmacokinetic Modelling Deconvolutes Physiological and Environmental Sources of Variability in Clozapine Exposure by Wills, Kenneth H, Behan, Stephen J, Nance, Michael J, Dawson, Jessica L, Polasek, Thomas M, Hopkins, Ashley M, van Dyk, Madelé, Rowland, Andrew

“…Clozapine is a key antipsychotic drug for treatment-resistant schizophrenia but exhibits highly variable pharmacokinetics and a propensity for serious adverse…”
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