Search Results - "Pol, Olga"

The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice by McDonnell, Christina, Leánez, Sergi, Pol, Olga

“…The involvement of heme oxygenase 1 (HO-1) in the modulation of the antinociceptive effects of opioids in type 1 diabetes has been demonstrated but the role…”
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The Induction of Heme Oxygenase 1 Decreases Painful Diabetic Neuropathy and Enhances the Antinociceptive Effects of Morphine in Diabetic Mice by Castany, Sílvia, Carcolé, Mireia, Leánez, Sergi, Pol, Olga

“…Painful diabetic neuropathy is a common complication of diabetes mellitus which is poorly controlled by conventional analgesics. This study investigates if…”
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The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice by McDonnell, Christina, Leánez, Sergi, Pol, Olga

“…The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity of delta-opioid receptors (DOR) in type 2 diabetic mice but the…”
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Sulforaphane Inhibited the Nociceptive Responses, Anxiety- and Depressive-Like Behaviors Associated With Neuropathic Pain and Improved the Anti-allodynic Effects of Morphine in Mice by Ferreira-Chamorro, Pablo, Redondo, Alejandro, Riego, Gabriela, Leánez, Sergi, Pol, Olga

“…Chronic neuropathic pain is associated with anxiety- and depressive-like disorders. Its treatment remains a serious clinical problem due to the lack of…”
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Effects of treatment with a carbon monoxide donor and an activator of heme oxygenase 1 on the nociceptive, apoptotic and/or oxidative alterations induced by persistent inflammatory pain in the central nervous system of mice by Cazuza, Rafael A., Batallé, Gerard, Bai, Xue, Leite-Panissi, Christie R.A., Pol, Olga

“…The activation of heme oxygenase 1 (HO-1)/carbon monoxide (CO) inhibits chronic inflammatory pain, but its role in the central nervous system (CNS) is not…”
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The Inhibitory Effects of Slow-Releasing Hydrogen Sulfide Donors in the Mechanical Allodynia, Grip Strength Deficits, and Depressive-Like Behaviors Associated with Chronic Osteoarthritis Pain by Batallé, Gerard, Cabarga, Laura, Pol, Olga

“…Osteoarthritis and its associated comorbidities are important clinical problems that have a negative impact on the quality of life, and its treatment remains…”
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A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice by Martínez-Martel, Ignacio, Pol, Olga

“…Patients undergoing chemotherapy with cisplatin (CIS) develop neuropathy in addition to other symptoms such as, anxiety, depression, muscle wasting and body…”
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Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice by Hervera, Arnau, Leánez, Sergi, Negrete, Roger, Motterlini, Roberto, Pol, Olga

“…Carbon monoxide (CO) synthesized by heme oxygenase 1 (HO-1) exerts antinociceptive effects during inflammation but its role during neuropathic pain remains…”
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The Interaction between Carbon Monoxide and Hydrogen Sulfide during Chronic Joint Pain in Young Female Mice by Batallé, Gerard, Bai, Xue, Pol, Olga

“…A relationship between carbon monoxide (CO) and hydrogen sulfide (H2S) has been described in different pathological conditions, but their interaction in…”
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The Anxiolytic and Antidepressant Effects of Diallyl Disulfide and GYY4137 in Animals with Chronic Neuropathic Pain by Bai, Xue, Batallé, Gerard, Pol, Olga

“…When neuropathic pain is maintained long term, it can also lead to the development of emotional disorders that are even more intense than pain perception and…”
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The Impact of UFP-512 in Mice with Osteoarthritis Pain: The Role of Hydrogen Sulfide by Batallé, Gerard, Bai, Xue, Balboni, Gianfranco, Pol, Olga

“…The pain-relieving properties of opioids in inflammatory and neuropathic pain are heightened by hydrogen sulfide (H S). However, whether allodynia and…”
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The role of carbon monoxide on the anti-nociceptive effects and expression of cannabinoid 2 receptors during painful diabetic neuropathy in mice by Castany, Sílvia, Carcolé, Mireia, Leánez, Sergi, Pol, Olga

“…Rationale The activation of cannabinoid 2 receptors (CB2R) attenuates chronic pain, but the role played by carbon monoxide synthesized by the inducible heme…”
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Hydrogen Sulfide Increases the Analgesic Effects of µ- and δ-Opioid Receptors during Neuropathic Pain: Pathways Implicated by Bai, Xue, Batallé, Gerard, Balboni, Gianfranco, Pol, Olga

“…Recent studies have revealed that hydrogen sulfide (H2S) increases the analgesic actions of the δ-opioid receptor (DOR) in inflammatory pain. However, the…”
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The role of gaseous neurotransmitters in the antinociceptive effects of morphine during acute thermal pain by Gou, Gemma, Leánez, Sergi, Pol, Olga

“…Treatment with a carbon monoxide-releasing molecule (tricarbonyldichlororuthenium(II) dimer, CORM-2) or a classical inducible heme oxygenase (HO-1) inducer…”
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The Antinociceptive, Antioxidant and Anti-Inflammatory Effects of 5-Fluoro-2-Oxindole during Inflammatory Pain by Redondo, Alejandro, Riego, Gabriela, Pol, Olga

“…Recent studies demonstrate that 5-fluoro-2-oxindole inhibits neuropathic pain but the antinociceptive actions of this drug and its effects on the plasticity,…”
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Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated by Polo, Sara, Díaz, Andrés Felipe, Gallardo, Núria, Leánez, Sergi, Balboni, Gianfranco, Pol, Olga

“…We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor…”
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New Treatment for the Cognitive and Emotional Deficits Linked with Paclitaxel-Induced Peripheral Neuropathy in Mice by Martínez-Martel, Ignacio, Bai, Xue, Batallé, Gerard, Pol, Olga

“…Chemotherapy-provoked peripheral neuropathy and its linked comorbidities severely reduce the quality of a patient's life. Its therapy is not completely…”
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Hydrogen Sulfide Interacting with Cannabinoid 2 Receptors during Sciatic Nerve Injury-Induced Neuropathic Pain by Bai, Xue, Batallé, Gerard, Martínez-Martel, Ignacio, Pol, Olga

“…Hydrogen sulfide (H S) donors make opioids more effective in inhibiting nociception during inflammatory and neuropathic pain. We examined whether the…”
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The Combination of Molecular Hydrogen and Heme Oxygenase 1 Effectively Inhibits Neuropathy Caused by Paclitaxel in Mice by Martínez-Martel, Ignacio, Bai, Xue, Kordikowski, Rebecca, Leite-Panissi, Christie R A, Pol, Olga

“…Chemotherapy-provoked peripheral neuropathy and its associated affective disorders are important adverse effects in cancer patients, and its treatment is not…”
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The Recovery of Cognitive and Affective Deficiencies Linked with Chronic Osteoarthritis Pain and Implicated Pathways by Slow-Releasing Hydrogen Sulfide Treatment by Batallé, Gerard, Bai, Xue, Pouso-Vázquez, Enric, Roch, Gerad, Rodríguez, Laura, Pol, Olga

“…Chronic osteoarthritis pain is accompanied by several comorbidities whose treatment has not been completely resolved. The anti-inflammatory, analgesic, and…”
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