Search Results - "Pokorná, Šárka"

Biomembrane Permeabilization: Statistics of Individual Leakage Events Harmonize the Interpretation of Vesicle Leakage by Braun, Stefan, Pokorná, Šárka, Šachl, Radek, Hof, Martin, Heerklotz, Heiko, Hoernke, Maria

“…The mode of action of membrane-active molecules, such as antimicrobial, anticancer, cell penetrating, and fusion peptides and their synthetic mimics,…”
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Apoptotic Bax at Oxidatively Stressed Mitochondrial Membranes: Lipid Dynamics and Permeabilization by Dingeldein, Artur Peter Günther, Pokorná, Šárka, Lidman, Martin, Sparrman, Tobias, Šachl, Radek, Hof, Martin, Gröbner, Gerhard

“…Mitochondria are crucial compartments of eukaryotic cells because they function as the cellular power plant and play a central role in the early stages of…”
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Distinct roles of SNARE-mimicking lipopeptides during initial steps of membrane fusion by Koukalová, Alena, Pokorná, Šárka, Boyle, Aimee L, Lopez Mora, Nestor, Kros, Alexander, Hof, Martin, Šachl, Radek

“…A model system for membrane fusion, inspired by SNARE proteins and based on two complementary lipopeptides CPnE4 and CPnK4, has been recently developed. It…”
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Oxidatively Stressed Mitochondrial Membranes: Insight into their Organization and Function during Apoptosis by Dingeldein, Artur P.G., Sparrman, Tobias, Åden, Jörgen, Wacklin, Hanna, Šachl, Radek, Pokorná, Šárka, Hof, Martin, Gröbner, Gerhard

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Effect of helical kink in antimicrobial peptides on membrane pore formation by Tuerkova, Alzbeta, Kabelka, Ivo, Králová, Tereza, Sukeník, Lukáš, Pokorná, Šárka, Hof, Martin, Vácha, Robert

“…Every cell is protected by a semipermeable membrane. Peptides with the right properties, for example Antimicrobial peptides (AMPs), can disrupt this protective…”
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GUV and LUV Leakage: How All-Or-None and Graded Leakage Scale with Vesicle Size by Braun, Stefan, Pokorná, Šárka, Šachl, Radek, Hof, Martin, Heerklotz, Heiko, Hoernke, Maria

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The Role of Lipids in Regulation of Programmed Cell Death by Lidman, Martin, Dingeldein, Artur, Pokorná, Šárka, Šachl, Radek, Sparrman, Tobias, Hof, Martin, Gröbner, Gerhard

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Controlled Peptide-Mediated Vesicle Fusion Assessed by Simultaneous Dual-Colour Time-Lapsed Fluorescence Microscopy by Mora, Nestor Lopez, Boyle, Aimee L., Kolck, Bart Jan van, Rossen, Anouk, Pokorná, Šárka, Koukalová, Alena, Šachl, Radek, Hof, Martin, Kros, Alexander

“…We have employed a model system, inspired by SNARE proteins, to facilitate membrane fusion between Giant Unilamellar Vesicles (GUVs) and Large Unilamellar…”
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The oxidized phospholipid PazePC promotes permeabilization of mitochondrial membranes by Bax by Lidman, Martin, Pokorná, Šárka, Dingeldein, Artur P.G., Sparrman, Tobias, Wallgren, Marcus, Šachl, Radek, Hof, Martin, Gröbner, Gerhard

“…Mitochondria play a crucial role in programmed cell death via the intrinsic apoptotic pathway, which is tightly regulated by the B-cell CLL/lymphoma-2 (Bcl-2)…”
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Membrane activity of the pentaene macrolide didehydroroflamycoin in model lipid bilayers by Koukalová, Alena, Pokorná, Šárka, Fišer, Radovan, Kopecký, Vladimír, Humpolíčková, Jana, Černý, Jan, Hof, Martin

“…Didehydroroflamycoin (DDHR), a recently isolated member of the polyene macrolide family, was shown to have antibacterial and antifungal activity. However, its…”
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Does fluoride disrupt hydrogen bond network in cationic lipid bilayer? Time-dependent fluorescence shift of Laurdan and molecular dynamics simulations by Pokorna, Sarka, Jurkiewicz, Piotr, Vazdar, Mario, Cwiklik, Lukasz, Jungwirth, Pavel, Hof, Martin

“…Time-dependent fluorescence shift (TDFS) of Laurdan embedded in phospholipid bilayers reports on hydration and mobility of the phospholipid acylgroups…”
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The complex nature of calcium cation interactions with phospholipid bilayers by Melcrová, Adéla, Pokorna, Sarka, Pullanchery, Saranya, Kohagen, Miriam, Jurkiewicz, Piotr, Hof, Martin, Jungwirth, Pavel, Cremer, Paul S., Cwiklik, Lukasz

“…Understanding interactions of calcium with lipid membranes at the molecular level is of great importance in light of their involvement in calcium signaling,…”
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Cell lipid droplet heterogeneity and altered biophysical properties induced by cell stress and metabolic imbalance by Ventura, Ana E., Pokorna, Sarka, Huhn, Natalie, Santos, Tânia C.B., Prieto, Manuel, Futerman, Anthony H., Silva, Liana C.

“…Lipid droplets (LD) are important regulators of lipid metabolism and are implicated in several diseases. However, the mechanisms underlying the roles of LD in…”
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Concurrent Compression of Phospholipid Membranes by Calcium and Cholesterol by Melcrová, Adéla, Pokorna, Sarka, Vošahlíková, Miroslava, Sýkora, Jan, Svoboda, Petr, Hof, Martin, Cwiklik, Lukasz, Jurkiewicz, Piotr

“…Regulation of cell metabolism, membrane fusion, association of proteins with cellular membranes, and cellular signaling altogether would not be possible…”
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Kink in Helical Peptides Affects Membrane Pore Formation by Turkova, Alzbeta, Kabelka, Ivo, Kralova, Tereza, Sukenik, Lukas, Pokorna, Sarka, Hof, Martin, Vacha, Robert

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Design of a stable human acid‐β‐glucosidase: towards improved Gaucher disease therapy and mutation classification by Pokorna, Sarka, Khersonsky, Olga, Lipsh‐Sokolik, Rosalie, Goldenzweig, Adi, Nielsen, Rebekka, Ashani, Yacov, Peleg, Yoav, Unger, Tamar, Albeck, Shira, Dym, Orly, Tirosh, Asa, Tarayra, Rana, Hocquemiller, Michaël, Laufer, Ralph, Ben‐Dor, Shifra, Silman, Israel, Sussman, Joel L., Fleishman, Sarel J., Futerman, Anthony H.

“…Acid‐β‐glucosidase (GCase, EC3.2.1.45), the lysosomal enzyme which hydrolyzes the simple glycosphingolipid, glucosylceramide (GlcCer), is encoded by the GBA1…”
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Laurdan in live cell imaging: Effect of acquisition settings, cell culture conditions and data analysis on generalized polarization measurements by Pokorna, Sarka, Ventura, Ana E., Santos, Tânia C.B., Hof, Martin, Prieto, Manuel, Futerman, Anthony H., Silva, Liana C.

“…Cell function is highly dependent on membrane structure, organization, and fluidity. Therefore, methods to probe the biophysical properties of biological…”
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Mitochondrial Membrane Organization in Regulation of Apoptosis by Dingeldein, Artur, Aden, Jörgen, Sparrman, Tobias, Sachl, Radek, Pokorna, Sarka, Hof, Martin, Gröbner, Gerhard

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Oxidized Lipids: Their Role in Regulation of Mitochondrial Apoptosis by Dingeldein, Artur, Aden, Jörgen, Sparrman, Tobias, Sachl, Radek, Pokorna, Sarka, Hof, Martin, Gröbner, Gerhard

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Interactions of monovalent salts with cationic lipid bilayers by Pokorna, Sarka, Jurkiewicz, Piotr, Cwiklik, Lukasz, Vazdar, Mario, Hof, Martin

“…The influence of monovalent salts (NaF, NaCl, NaBr, NaClO4, KCl) on the properties of lipid bilayers composed of binary mixtures of zwitterionic DOPC…”
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