Anticancer potential of 3-hydroxypyridine-2-carboxaldehyde N(4)-methyl and pyrrolidinylthiosemicarbazones and their Zn(II) complexes in different cancers via targeting MAPK superfamily signaling pathway

Schematic representation of mechanism of action of HHyPyPyrd on cancer cell proliferation. [Display omitted] Zinc(II) complexes of 3-hydroxy-2-formylpyridine N(4)-methylthiosemicarbazone (1) and 3-hydroxy-2-formylpyridine N(4)-pyrrolidinyl thiosemicarbazone (2) respectively have been synthesized and...

Full description

Saved in:

Bibliographic Details
Published in:	Results in Chemistry Vol. 3; p. 100104
Main Authors:	Shahi, Nerina, Pandey, Vivek, Pathak, Ankita, Thapa, Ram Sundar, Pokhrel, Prabina, Pokharel, Yuba Raj, Yadav, Paras Nath
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-01-2021 Elsevier
Subjects:	3-Hydroxypyridine Anti-cancer activities ESI-mass spectrometry MAPK signaling pathway Thiosemicarbazone ZN(II) complexes 3-Hydroxypyridine Anti-cancer activities ESI-mass spectrometry Thiosemicarbazone ZN(II) complexes MAPK signaling pathway
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Schematic representation of mechanism of action of HHyPyPyrd on cancer cell proliferation. [Display omitted] Zinc(II) complexes of 3-hydroxy-2-formylpyridine N(4)-methylthiosemicarbazone (1) and 3-hydroxy-2-formylpyridine N(4)-pyrrolidinyl thiosemicarbazone (2) respectively have been synthesized and characterized by elemental analysis, IR, UV–Vis, 1H NMR spectroscopy and mass spectrometry. These compounds were investigated for their antiproliferative potential against PC3 (Prostate Cancer), DU145 (Prostate Cancer), A549 (Lung Cancer), A431 (skin cancer) and Hela (Cervical Cancer cell) cell lines. All the compounds showed good antiproliferative activity against the tested cell lines. However, compound HHyPyPyrd showed remarkable antiproliferative activity against PC3 cell line with an IC50 of 0.69 µM. Cell death analysis by propidium iodide staining showed significant increase in cell death of PC3 cells in a concentration dependent manner. Furthermore, cell cycle analysis showed cell cycle arrest of PC3 cells at S phase. Our study shows that compound HHyPyPyrd induces the downregulation of JNK, c-Jun and Erk.
ISSN:	2211-7156 2211-7156
DOI:	10.1016/j.rechem.2021.100104