Search Results - "Pojoga, Luminita"

Mineralocorticoid receptor and aldosterone: Interaction between NR3C2 genetic variants, sex and age in a mixed cohort by Heydarpour, Mahyar, Parksook, Wasita W, Pojoga, Luminita H, Williams, Gordon H, Williams, Jonathan S

“…Hypertension, a prevalent cardiovascular risk, often involves dysregulated aldosterone and its interaction with the mineralocorticoid receptor (MR)…”
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Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II by Shukri, Mohammad Zaki, Tan, Jia Wei, Manosroi, Worapaka, Pojoga, Luminita H, Rivera, Alicia, Williams, Jonathan S, Seely, Ellen W, Adler, Gail K, Jaffe, Iris Z, Karas, Richard H, Williams, Gordon H, Romero, Jose R

“…The relationship between biological sex and aldosterone on blood pressure (BP) is unclear. We hypothesized that sex would modify the interaction between…”
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Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population by Aljaibeji, Hayat, Heydarpour, Mahyar, Stanton, Ana Maria, Williams, Jonathan S, Pojoga, Luminita H, Romero, Jose R, Williams, Gordon H

“…The mTOR (mechanistic target of rapamycin) is an essential regulator of fundamental biological processes. mTOR forms 2 distinct complexes, mTORC1 (mTOR complex…”
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Striatin Gene Variants Are Associated With Salt Sensitivity of Blood Pressure by Mechanisms That Differ in Women and Men by Gholami, Shadi K, Heydarpour, Mahyar, Williams, Jonathan S, Pojoga, Luminita H, Adler, Gail K, Williams, Gordon H, Romero, Jose R

“…Salt sensitivity of blood pressure (SSBP) is a substantial risk factor for cardiovascular morbidity and mortality. Striatin (STRN) is critical for estrogen and…”
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A candidate locus in the renalase gene and susceptibility to blood pressure responses to the dietary salt by Heydarpour, Mahyar, Parksook, Wasita W., Hopkins, Paul N., Pojoga, Luminita H., Williams, Gordon H., Williams, Jonathan S.

“…High dietary salt confers a risk of elevating blood pressure (BP) and the development of hypertension. BP to salt intake may be determined in part by…”
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Longitudinal changes in blood pressure are preceded by changes in albuminuria and accelerated by increasing dietary sodium intake by Katayama, Isis Akemi, Huang, Yuefei, Garza, Amanda E., Brooks, Danielle L., Williams, Jonathan S., Nascimento, Mariana M., Heimann, Joel C., Pojoga, Luminita H.

“…Dietary sodium is a well-known risk factor for cardiovascular and renal disease; however, direct evidence of the longitudinal changes that occur with aging,…”
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Salt Sensitivity of Blood Pressure and Aldosterone: Interaction Between the Lysine-specific Demethylase 1 Gene, Sex, and Age by Parksook, Wasita W, Heydarpour, Mahyar, Gholami, Shadi K, Luther, James M, Hopkins, Paul N, Pojoga, Luminita H, Williams, Jonathan S

“…Salt sensitivity of blood pressure (SSBP) is associated with increased cardiovascular risk, especially in individuals of African descent, although the…”
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Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor by Treesaranuwattana, Thitinan, Wong, Kelly Yin Han, Brooks, Danielle L., Tay, Chee Sin, Williams, Gordon H., Williams, Jonathan S., Pojoga, Luminita H.

“…LSD1 (lysine-specific demethylase-1) is an epigenetic regulator of gene transcription. LSD1 risk allele in humans and LSD1 deficiency (LSD1+/−) in mice confer…”
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Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone by Brown, Jenifer M, Williams, Jonathan S, Luther, James M, Garg, Rajesh, Garza, Amanda E, Pojoga, Luminita H, Ruan, Daniel T, Williams, Gordon H, Adler, Gail K, Vaidya, Anand

“…Observational studies in primary hyperaldosteronism suggest a positive relationship between aldosterone and parathyroid hormone (PTH); however, interventions…”
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Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner by Tan, Yi Jun Desmond, Brooks, Danielle L, Wong, Kelly Yin Han, Huang, Yuefei, Romero, Jose R, Williams, Jonathan S, Pojoga, Luminita H

“…Biologic sex influences the development of cardiovascular disease and modifies aldosterone (ALDO) and blood pressure (BP) phenotypes: females secrete more…”
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Effects of Mineralocorticoid Receptor Blockade and Statins on Kidney Injury Marker 1 (KIM-1) in Female Rats Receiving L-NAME and Angiotensin II by Huang, Jiayan, Caliskan Guzelce, Ezgi, Gholami, Shadi K, Gawelek, Kara L, Mitchell, Richard N, Pojoga, Luminita H, Romero, Jose R, Williams, Gordon H, Adler, Gail K

“…Kidney injury molecule-1 (KIM-1) is a biomarker of renal injury and a predictor of cardiovascular disease. Aldosterone, via activation of the mineralocorticoid…”
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Regulation of aldosterone secretion by mineralocorticoid receptor–mediated signaling by Chong, Cherish, Hamid, Anis, Yao, Tham, Garza, Amanda E, Pojoga, Luminita H, Adler, Gail K, Romero, Jose R, Williams, Gordon H

“…We posit the existence of a paracrine/autocrine negative feedback loop, mediated by the mineralocorticoid receptor (MR), regulating aldosterone secretion. To…”
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Biological sex modifies aldosterone’s secretion at a cellular level by Gholami, Shadi K, Tay, Chee Sin, Lee, Jessica M, Zagoren, Eleanor, Maris, Stephen A, Wong, Jian Yao, Garza, Amanda E, Caliskan Guzelce, Ezgi, Pojoga, Luminita H, Adler, Gail K, Romero, Jose R, Williams, Gordon H

“…Inconsistencies have been reported on the effect of sex on aldosterone (ALDO) levels leading to clinical confusion. The reasons for these inconsistencies are…”
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Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects by Baudrand, Rene, Pojoga, Luminita H, Vaidya, Anand, Garza, Amanda E, Vöhringer, Paul A, Jeunemaitre, Xavier, Hopkins, Paul N, Yao, Tham M, Williams, Jonathan, Adler, Gail K, Williams, Gordon H

“…BACKGROUND—Statins substantially reduce cardiovascular mortality and appear to have beneficial effects independent of their lipid-lowering properties. We…”
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Histone demethylase LSD1 deficiency and biological sex: impact on blood pressure and aldosterone production by Huang, Yuefei, Ting, Pei Yee, Yao, Tham M, Homma, Tsuyoshi, Brooks, Danielle, Katayama Rangel, Isis, Adler, Gail K, Romero, Jose R, Williams, Jonathan S, Pojoga, Luminita H, Williams, Gordon H

“…Human risk allele carriers of lysine-specific demethylase 1 (LSD1) and LSD1-deficient mice have salt-sensitive hypertension for unclear reasons. We…”
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Striatin heterozygous mice are more sensitive to aldosterone-induced injury by Garza, Amanda E, Trefts, Elijah, Katayama Rangel, Isis A, Brooks, Danielle, Baudrand, Rene, Moize, Burhanuddin, Romero, Jose R, Ranjit, Sanjay, Treesaranuwattana, Thitinan, Yao, Tham M, Adler, Gail K, Pojoga, Luminita H, Williams, Gordon H

“…Aldosterone modulates the activity of both epithelial (specifically renal) and non-epithelial cells. Binding to the mineralocorticoid receptor (MR), activates…”
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Interplay Between Statins, Cav1 (Caveolin-1), and Aldosterone by Haas, Andrea V., Baudrand, Rene, Easly, Rebecca M., Murray, Gillian R., Touyz, Rhian M., Pojoga, Luminita H., Jeunemaitre, Xavier, Hopkins, Paul N., Rosner, Bernard, Williams, Jonathan S., Williams, Gordon H., Adler, Gail K.

“…Statin use is associated with lower aldosterone levels. We hypothesized that caveolin-1 may be important for the uptake of statins into the adrenal gland and…”
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Caloric restriction improves glucose homeostasis, yet increases cardiometabolic risk in caveolin-1-deficient mice by Mayurasakorn, Korapat, Hasanah, Nurul, Homma, Tsuyoshi, Homma, Mika, Rangel, Isis Katayama, Garza, Amanda E., Romero, Jose R., Adler, Gail K., Williams, Gordon H., Pojoga, Luminita H.

“…The plasma membrane protein caveolin-1 (CAV-1) has been shown to be involved in modulating glucose homeostasis and the actions of the…”
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The Association of Estrogen Receptor-β Gene Variation With Salt-Sensitive Blood Pressure by Manosroi, Worapaka, Tan, Jia Wei, Rariy, Chevon M, Sun, Bei, Goodarzi, Mark O, Saxena, Aditi R, Williams, Jonathan S, Pojoga, Luminita H, Lasky-Su, Jessica, Cui, Jinrui, Guo, Xiuqing, Taylor, Kent D, Chen, Yii-Der I, Xiang, Anny H, Hsueh, Willa A, Raffel, Leslie J, Buchanan, Thomas A, Rotter, Jerome I, Williams, Gordon H, Seely, Ellen W

“…Abstract Context Hypertension in young women is uncommon compared with young men and older women. Estrogen appears to protect most women against hypertension,…”
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Aldosteroneʼs mechanism of action: roles of lysine-specific demethylase 1, caveolin and striatin by Baudrand, Rene, Pojoga, Luminita H, Romero, Jose R, Williams, Gordon H

“…PURPOSE OF REVIEWAldosteroneʼs functions and mechanisms of action are different depending on the tissue and the environmental condition. The mineralocorticoid…”
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