Search Results - "Poirier, Michelle"

Protein aggregation and neurodegenerative disease by Ross, Christopher A, Poirier, Michelle A

“…Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion…”
Get full text

What is the role of protein aggregation in neurodegeneration? by Ross, Christopher A, Poirier, Michelle A

Get full text

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation by Spiess, Christoph, Joachimiak, Lukasz, Frydman, Judith, Tam, Stephen, Poirier, Michelle A, Auyeung, William, Chen, Bryan

“…The eukaryotic group II chaperonin TRiC can block polyQ tract aggregation, present in proteins such as Htt. Here the TRiC-Htt interaction is examined using in…”
Get full text

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core by Lin, Hsiang-Kai, Boatz, Jennifer C., Krabbendam, Inge E., Kodali, Ravindra, Hou, Zhipeng, Wetzel, Ronald, Dolga, Amalia M., Poirier, Michelle A., van der Wel, Patrick C. A.

“…Polyglutamine expansion in the huntingtin protein is the primary genetic cause of Huntington’s disease (HD). Fragments coinciding with mutant huntingtin exon1…”
Get full text

Polyglutamine Amyloid Core Boundaries and Flanking Domain Dynamics in Huntingtin Fragment Fibrils Determined by Solid-State Nuclear Magnetic Resonance by Hoop, Cody L, Lin, Hsiang-Kai, Kar, Karunakar, Hou, Zhipeng, Poirier, Michelle A, Wetzel, Ronald, van der Wel, Patrick C. A

“…In Huntington’s disease, expansion of a polyglutamine (polyQ) domain in the huntingtin (htt) protein leads to misfolding and aggregation. There is much…”
Get full text

Identification of Novel Potentially Toxic Oligomers Formed in Vitro from Mammalian-derived Expanded huntingtin Exon-1 Protein by Nucifora, Leslie G., Burke, Kathleen A., Feng, Xia, Arbez, Nicolas, Zhu, Shanshan, Miller, Jason, Yang, Guocheng, Ratovitski, Tamara, Delannoy, Michael, Muchowski, Paul J., Finkbeiner, Steven, Legleiter, Justin, Ross, Christopher A., Poirier, Michelle A.

“…Huntington disease is a genetic neurodegenerative disorder that arises from an expanded polyglutamine region in the N terminus of the HD gene product,…”
Get full text

Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells by Ratovitski, Tamara, Gucek, Marjan, Jiang, Haibing, Chighladze, Ekaterine, Waldron, Elaine, D'Ambola, James, Hou, Zhipeng, Liang, Yideng, Poirier, Michelle A., Hirschhorn, Ricky R., Graham, Rona, Hayden, Michael R., Cole, Robert N., Ross, Christopher A.

“…Huntingtin proteolysis is implicated in Huntington disease pathogenesis, yet, the nature of huntingtin toxic fragments remains unclear. Huntingtin undergoes…”
Get full text

Huntingtin Spheroids and Protofibrils as Precursors in Polyglutamine Fibrilization by Poirier, Michelle A, Li, Huilin, Macosko, Jed, Cai, Shuowei, Amzel, Mario, Ross, Christopher A

“…The pathology of Huntington's disease is characterized by neuronal degeneration and inclusions containing N-terminal fragments of mutant huntingtin (htt). To…”
Get full text

Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin by Jiang, Haibing, Poirier, Michelle A., Liang, Yideng, Pei, Zhong, Weiskittel, Charlotte E., Smith, Wanli W., DeFranco, Donald B., Ross, Christopher A.

“…Huntington's disease is a neurodegenerative disease caused by an expanded polyglutamine stretch within the huntingtin protein. Transfection of mutant…”
Get full text

Baicalein reduces E46K α-synuclein aggregation in vitro and protects cells against E46K α-synuclein toxicity in cell models of familiar Parkinsonism by Jiang, Mali, Porat-Shliom, Yair, Pei, Zhong, Cheng, Yong, Xiang, Lan, Sommers, Katherine, Li, Qing, Gillardon, Frank, Hengerer, Bastian, Berlinicke, Cynthia, Smith, Wanli W, Zack, Donald J, Poirier, Michelle A, Ross, Christopher A, Duan, Wenzhen

“…J. Neurochem. (2010) 114, 419-429. The E46K is a point mutation in α-synuclein (α-syn) that causes familial Parkinsonism with Lewy body dementia. We have now…”
Get full text

Meditation-induced bloodborne factors as an adjuvant treatment to COVID-19 disease by Zuniga-Hertz, Juan P., Chitteti, Ramamurthy, Dispenza, Joe, Cuomo, Raphael, Bonds, Jacqueline A., Kopp, Elena L., Simpson, Sierra, Okerblom, Jonathan, Maurya, Svetlana, Rana, Brinda K., Miyonahara, Atsushi, Niesman, Ingrid R., Maree, Jacqueline, Belza, Gianna, Hamilton, Hillari D., Stanton, Carla, Gonzalez, David J., Poirier, Michelle A., Moeller-Bertram, Tobias, Patel, Hemal H.

“…The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. Management of the pandemic has relied mainly on SARS-CoV-2 vaccines, while…”
Get full text

A Compact β Model of huntingtin Toxicity by Zhang, Qi Charles, Yeh, Tzu-lan, Leyva, Alfonso, Frank, Leslie G., Miller, Jason, Kim, Yujin E., Langen, Ralf, Finkbeiner, Steven, Amzel, Mario L., Ross, Christopher A., Poirier, Michelle A.

“…Huntington disease results from an expanded polyglutamine region in the N terminus of the huntingtin protein. HD pathology is characterized by neuronal…”
Get full text

A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure by Poirier, Michelle A., Jiang, Haibing, Ross, Christopher A.

“…Huntington's disease (HD) arises from an expanded polyglutamine (polyQ) in the N-terminus of the huntingtin (htt) protein. Neuronal degeneration and inclusions…”
Get full text

Polyglutamine Fibrillogenesis: The Pathway Unfolds by Ross, Christopher A., Poirier, Michelle A., Wanker, Erich E., Amzel, Mario

“…Ross et al discuss recent research regarding polyglutamine (polyGln) and neurodegenerative diseases. Even if polyGln inclusions are not the major toxic…”
Get full text

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice by Schilling, Gabriele, Savonenko, Alena V., Klevytska, Alexandra, Morton, Johanna L., Tucker, Stina M., Poirier, Michelle, Gale, Alexa, Chan, Ning, Gonzales, Vicky, Slunt, Hilda H., Coonfield, Michael L., Jenkins, Nancy A., Copeland, Neal G., Ross, Christopher A., Borchelt, David R.

“…Huntington's disease (HD) results from the expansion of a glutamine repeat near the N-terminus of huntingtin (htt). At post-mortem, neurons in the central…”
Get full text

ATF3 plays a protective role against toxicity by N -terminal fragment of mutant huntingtin in stable PC12 cell line by Liang, Yideng, Jiang, Haibing, Ratovitski, Tamara, Jie, Chunfa, Nakamura, Masayuki, Hirschhorn, Ricky R, Wang, Xiaofang, Smith, Wanli W, Hai, Tsonwin, Poirier, Michelle A, Ross, Christopher A

“…Abstract Huntington's disease is a progressive neurodegenerative disorder caused by a polyglutamine expansion near the N-terminus of huntingtin. The mechanisms…”
Get full text

The neuronal t-SNARE complex is a parallel four-helix bundle by Shin, Yeon-Kyun, Xiao, Wenzhong, Poirier, Michelle A, Bennett, Mark K

“…Assembly of the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) complex is an essential step for neurotransmitter release in…”
Get full text

The synaptic SNARE complex is a parallel four-stranded helical bundle by Bennett, Mark K, Poirier, Michelle A, Xiao, Wenzhong, Macosko, Jed C, Chan, Charles, Shin, Yeon-Kyun

“…The heterotrimeric synaptic soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, consisting of the synaptic…”
Get full text

Intergenerational Pathways into Family Sex Market Facilitation by Horning, Amber, Poirier, Michelle, Jordenö, Sara

“…Prior studies have found that 15-31% of sex market facilitators (SMFs) experienced family trafficking, and this was a primary route of market entrance (Dank et…”
Get full text

A Visual Psychogeography Approach: Mapping Sex Market Facilitation in New York City by Horning, Amber, Jordenö, Sara, Motiwala, Punit, Poirier, Michelle

“…The geography of sex work has received attention from scholars exploring its ebb and flow based on how police, neighbors, and gentrification influence sex work…”
Get full text