Search Results - "Poirier, Marion"

Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB‐17 Fragment Library by Pujol‐Giménez, Jonai, Poirier, Marion, Bühlmann, Sven, Schuppisser, Céline, Bhardwaj, Rajesh, Awale, Mahendra, Visini, Ricardo, Javor, Sacha, Hediger, Matthias A., Reymond, Jean‐Louis

“…Solute carrier proteins (SLCs) are membrane proteins controlling fluxes across biological membranes and represent an emerging class of drug targets. Here we…”
Get full text

Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds by Manatschal, Cristina, Pujol-Giménez, Jonai, Poirier, Marion, Reymond, Jean-Louis, Hediger, Matthias A, Dutzler, Raimund

“…In humans, the divalent metal ion transporter-1 (DMT1) mediates the transport of ferrous iron across the apical membrane of enterocytes. Hence, its inhibition…”
Get full text

Integrating extended focused assessment with sonography for trauma (eFAST) in the initial assessment of severe trauma: Impact on the management of 756 patients by Zieleskiewicz, Laurent, Fresco, Raphaelle, Duclos, Gary, Antonini, François, Mathieu, Calypso, Medam, Sophie, Vigne, Coralie, Poirier, Marion, Roche, Pierre-Hugues, Bouzat, Pierre, Kerbaul, François, Scemama, Ugo, Bège, Thierry, Thomas, Pascal Alexandre, Flecher, Xavier, Hammad, Emmanuelle, Leone, Marc

“…Before total body computed tomography scan, an initial rapid imaging assessment should be conducted in the trauma bay. It generally includes a chest x-ray,…”
Get full text

Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT‐β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2 by Poirier, Marion, Awale, Mahendra, Roelli, Matthias A., Giuffredi, Guy T., Ruddigkeit, Lars, Evensen, Lasse, Stooss, Amandine, Calarco, Serafina, Lorens, James B., Charles, Roch‐Philippe, Reymond, Jean‐Louis

“…By screening a focused library of kinase inhibitor analogues in a phenotypic co‐culture assay for angiogenesis inhibition, we identified an aminotriazine that…”
Get full text

Front Cover: Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT‐β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2 (ChemMedChem 2/2019) by Poirier, Marion, Awale, Mahendra, Roelli, Matthias A., Giuffredi, Guy T., Ruddigkeit, Lars, Evensen, Lasse, Stooss, Amandine, Calarco, Serafina, Lorens, James B., Charles, Roch‐Philippe, Reymond, Jean‐Louis

“…The Front Cover illustrates the chemical space distance relationship between an angiogenesis inhibitory triazine identified in a phenotypic screen (structure…”
Get full text

Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation by Poirier, Marion, Pujol-Giménez, Jonai, Manatschal, Cristina, Bühlmann, Sven, Embaby, Ahmed, Javor, Sacha, Hediger, Matthias A, Reymond, Jean-Louis

“…Solute carrier proteins (SLCs) control fluxes of ions and molecules across biological membranes and represent an emerging class of drug targets. SLC11A2…”
Get full text

Frontiers in Medicinal Chemistry 2017 in Bern, Switzerland by Probst, Daniel, Heitz, Marc, Poirier, Marion, Gan, Bee Ha, Delalande, Clémence, Reymond, Jean‐Louis

“…Sharing capital ideas: The 2017 Frontiers in Medicinal Chemistry (FiMC) conference, organized jointly by the German Chemical Society, the German Pharmaceutical…”
Get full text

Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation† †Electronic supplementary information (ESI) available: Methods for bioassays, details of kinetic studies, SMARTS pattern analysis, chemical synthesis procedures and compound characterization, X-ray deposition information, HPLC purity table, NMR spectra of final compounds, and SMILES list of final compounds with activities and of compounds extracted from ChEMBL. CCDC 1976759, 1976832 and by Poirier, Marion, Pujol-Giménez, Jonai, Manatschal, Cristina, Bühlmann, Sven, Embaby, Ahmed, Javor, Sacha, Hediger, Matthias A., Reymond, Jean-Louis

“…Activity optimization of a pyrazolyl-pyrimidone against the iron transporter SLC11A2 (hDMT1) and mechanistic studies revealed that this class of inhibitors act…”
Get full text