Search Results - "Poirier, G. G."
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1
Biophysics of Chromatin Dynamics
Published in Annual review of biophysics (06-05-2019)“…Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate DNA processes, including transcription, replication, and repair…”
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2
Acute toxicity of 6 neonicotinoid insecticides to freshwater invertebrates
Published in Environmental toxicology and chemistry (01-05-2018)“…Neonicotinoids are a group of insecticides commonly used in agriculture. Due to their high water solubility, neonicotinoids can be transported to surface…”
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3
Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation
Published in Nature communications (12-03-2019)“…Protein ADP-ribosylation is essential for the regulation of several cellular pathways, enabling dynamic responses to diverse pathophysiological conditions. It…”
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CARM1 regulates replication fork speed and stress response by stimulating PARP1
Published in Molecular cell (18-02-2021)“…DNA replication forks use multiple mechanisms to deal with replication stress, but how the choice of mechanisms is made is still poorly understood. Here, we…”
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Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility
Published in Nucleic acids research (07-05-2021)“…Abstract Hexasomes and tetrasomes are intermediates in nucleosome assembly and disassembly. Their formation is promoted by histone chaperones, ATP-dependent…”
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Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
Published in Cancer research (Chicago, Ill.) (15-08-2014)“…The BRCA1-associated deubiquitylase BAP1 is mutated in several cancers, most notably mesothelioma and melanoma, where it is thought to promote oncogenesis. In…”
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Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
Published in Nature communications (04-07-2019)“…PARP-1 is rapidly recruited and activated by DNA double-strand breaks (DSBs). Upon activation, PARP-1 synthesizes a structurally complex polymer composed of…”
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Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
Published in Proceedings of the National Academy of Sciences - PNAS (15-07-2014)“…Excessive poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation kills cells via a cell-death process designated “parthanatos” in which PAR induces the…”
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No evidence of spherical microplastics (10–300 μm) translocation in adult rainbow trout (Oncorhynchus mykiss) after a two-week dietary exposure
Published in PloS one (25-09-2020)“…The consumption of fish contaminated with microplastics is often cited as a pathway for human exposure. However, because their guts are generally removed…”
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Seasona evolution of active layer thaw depth and hillslope‐stream connectivity in a permafrost watershed
Published in Water resources research (01-01-2020)“…To advance our understanding of permafrost hillslope drainage dynamics and its influence on streamflow hydrochemistry, we instrumented a hillslope‐stream…”
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ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD+ Depletion
Published in Cell reports (Cambridge) (25-09-2014)“…ARTD1 (PARP1) is a key enzyme involved in DNA repair through the synthesis of poly(ADP-ribose) (PAR) in response to strand breaks, and it plays an important…”
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The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice
Published in Nature cell biology (01-11-2015)“…DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining or homologous recombination (HR). Cell cycle stage and DNA end resection are…”
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PARP1 associates with R-loops to promote their resolution and genome stability
Published in Nucleic acids research (21-03-2023)“…Abstract PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate…”
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Poly(ADP‐ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation
Published in The FASEB journal (31-03-2024)“…PARP‐1 over‐activation results in cell death via excessive PAR generation in different cell types, including neurons following brain ischemia. Glycolysis,…”
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Dissociation rate compensation mechanism for budding yeast pioneer transcription factors
Published in eLife (19-03-2019)“…Nucleosomes restrict the occupancy of most transcription factors (TF) by reducing binding and accelerating dissociation, while a small group of TFs have high…”
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PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent
Published in PloS one (24-10-2012)“…Poly(ADP-ribose) polymerase-1 (PARP-1) is widely involved in cell death responses. Depending on the degree of injury and on cell type, PARP activation may lead…”
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Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro
Published in Clinical cancer research (15-03-2012)“…Poly(ADP-ribose) polymerase (PARP) inhibitors are undergoing extensive clinical testing for their single-agent activity in homologous recombination…”
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Nucleosomes accelerate transcription factor dissociation
Published in Nucleic acids research (01-03-2014)“…Transcription factors (TF) bind DNA-target sites within promoters to activate gene expression. TFs target their DNA-recognition sequences with high specificity…”
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Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)
Published in Science signaling (05-04-2011)“…The mitochondrial protein apoptosis-inducing factor (AIF) plays a pivotal role in poly(ADP-ribose) polymerase-1 (PARP-1)-mediated cell death (parthanatos),…”
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Low cost and massively parallel force spectroscopy with fluid loading on a chip
Published in Nature communications (10-11-2022)“…Current approaches for single molecule force spectroscopy are typically constrained by low throughput and high instrumentation cost. Herein, a low-cost, high…”
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