Search Results - "Poirier, G. G."

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  1. 1

    Biophysics of Chromatin Dynamics by Fierz, Beat, Poirier, Michael G

    Published in Annual review of biophysics (06-05-2019)
    “…Nucleosomes and chromatin control eukaryotic genome accessibility and thereby regulate DNA processes, including transcription, replication, and repair…”
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  2. 2

    Acute toxicity of 6 neonicotinoid insecticides to freshwater invertebrates by Raby, Melanie, Nowierski, Monica, Perlov, Dmitri, Zhao, Xiaoming, Hao, Chunyan, Poirier, David G., Sibley, Paul K.

    Published in Environmental toxicology and chemistry (01-05-2018)
    “…Neonicotinoids are a group of insecticides commonly used in agriculture. Due to their high water solubility, neonicotinoids can be transported to surface…”
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  3. 3

    Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation by O’Sullivan, Julia, Tedim Ferreira, Maria, Gagné, Jean-Philippe, Sharma, Ajit K., Hendzel, Michael J., Masson, Jean-Yves, Poirier, Guy G.

    Published in Nature communications (12-03-2019)
    “…Protein ADP-ribosylation is essential for the regulation of several cellular pathways, enabling dynamic responses to diverse pathophysiological conditions. It…”
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  4. 4

    CARM1 regulates replication fork speed and stress response by stimulating PARP1 by Genois, Marie-Michelle, Gagné, Jean-Philippe, Yasuhara, Takaaki, Jackson, Jessica, Saxena, Sneha, Langelier, Marie-France, Ahel, Ivan, Bedford, Mark T., Pascal, John M., Vindigni, Alessandro, Poirier, Guy G., Zou, Lee

    Published in Molecular cell (18-02-2021)
    “…DNA replication forks use multiple mechanisms to deal with replication stress, but how the choice of mechanisms is made is still poorly understood. Here, we…”
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  5. 5

    Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility by Morrison, Emma A, Baweja, Lokesh, Poirier, Michael G, Wereszczynski, Jeff, Musselman, Catherine A

    Published in Nucleic acids research (07-05-2021)
    “…Abstract Hexasomes and tetrasomes are intermediates in nucleosome assembly and disassembly. Their formation is promoted by histone chaperones, ATP-dependent…”
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  6. 6

    Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair by ISMAIL HASSAN ISMAIL, DAVIDSON, Riley, GAGNE, Jean-Philippe, ZHI ZHONG XU, POIRIER, Guy G, HENDZEL, Michael J

    Published in Cancer research (Chicago, Ill.) (15-08-2014)
    “…The BRCA1-associated deubiquitylase BAP1 is mutated in several cancers, most notably mesothelioma and melanoma, where it is thought to promote oncogenesis. In…”
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    Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis by Andrabi, Shaida A., Umanah, George K. E., Chang, Calvin, Stevens, Daniel A., Karuppagounder, Senthilkumar S., Gagné, Jean-Philippe, Poirier, Guy G., Dawson, Valina L., Dawson, Ted M.

    “…Excessive poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation kills cells via a cell-death process designated “parthanatos” in which PAR induces the…”
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  9. 9

    No evidence of spherical microplastics (10–300 μm) translocation in adult rainbow trout (Oncorhynchus mykiss) after a two-week dietary exposure by Kim, Joel, Poirier, David G., Helm, Paul A., Bayoumi, Malak, Rochman, Chelsea M.

    Published in PloS one (25-09-2020)
    “…The consumption of fish contaminated with microplastics is often cited as a pathway for human exposure. However, because their guts are generally removed…”
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  10. 10

    Seasona evolution of active layer thaw depth and hillslope‐stream connectivity in a permafrost watershed by Chiasson‐Poirier, G., Franssen, J., Lafrenière, M. J., Fortier, D., Lamoureux, S. F.

    Published in Water resources research (01-01-2020)
    “…To advance our understanding of permafrost hillslope drainage dynamics and its influence on streamflow hydrochemistry, we instrumented a hillslope‐stream…”
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    The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice by Ismail, Ismail Hassan, Gagné, Jean-Philippe, Genois, Marie-Michelle, Strickfaden, Hilmar, McDonald, Darin, Xu, Zhizhong, Poirier, Guy G., Masson, Jean-Yves, Hendzel, Michael J.

    Published in Nature cell biology (01-11-2015)
    “…DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining or homologous recombination (HR). Cell cycle stage and DNA end resection are…”
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  13. 13

    PARP1 associates with R-loops to promote their resolution and genome stability by Laspata, Natalie, Kaur, Parminder, Mersaoui, Sofiane Yacine, Muoio, Daniela, Liu, Zhiyan Silvia, Bannister, Maxwell Henry, Nguyen, Hai Dang, Curry, Caroline, Pascal, John M, Poirier, Guy G, Wang, Hong, Masson, Jean-Yves, Fouquerel, Elise

    Published in Nucleic acids research (21-03-2023)
    “…Abstract PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate…”
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  14. 14

    Poly(ADP‐ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation by Hossain, M. Iqbal, Lee, Jun Hee, Gagné, Jean‐Philippe, Khan, Junaid, Poirier, Guy G., King, Peter H., Dawson, Valina L., Dawson, Ted M., Andrabi, Shaida A.

    Published in The FASEB journal (31-03-2024)
    “…PARP‐1 over‐activation results in cell death via excessive PAR generation in different cell types, including neurons following brain ischemia. Glycolysis,…”
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  15. 15

    Dissociation rate compensation mechanism for budding yeast pioneer transcription factors by Donovan, Benjamin T, Chen, Hengye, Jipa, Caroline, Bai, Lu, Poirier, Michael G

    Published in eLife (19-03-2019)
    “…Nucleosomes restrict the occupancy of most transcription factors (TF) by reducing binding and accelerating dissociation, while a small group of TFs have high…”
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  16. 16

    PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent by Ethier, Chantal, Tardif, Maxime, Arul, Laura, Poirier, Guy G

    Published in PloS one (24-10-2012)
    “…Poly(ADP-ribose) polymerase-1 (PARP-1) is widely involved in cell death responses. Depending on the degree of injury and on cell type, PARP activation may lead…”
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  17. 17

    Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro by PATEL, Anand G, DE LORENZO, Silvana B, FLATTEN, Karen S, POIRIER, Guy G, KAUFMANN, Scott H

    Published in Clinical cancer research (15-03-2012)
    “…Poly(ADP-ribose) polymerase (PARP) inhibitors are undergoing extensive clinical testing for their single-agent activity in homologous recombination…”
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  18. 18

    Nucleosomes accelerate transcription factor dissociation by Luo, Yi, North, Justin A, Rose, Sean D, Poirier, Michael G

    Published in Nucleic acids research (01-03-2014)
    “…Transcription factors (TF) bind DNA-target sites within promoters to activate gene expression. TFs target their DNA-recognition sequences with high specificity…”
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  19. 19

    Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos) by Wang, Yingfei, Kim, No Soo, Haince, Jean-Francois, Kang, Ho Chul, David, Karen K, Andrabi, Shaida A, Poirier, Guy G, Dawson, Valina L, Dawson, Ted M

    Published in Science signaling (05-04-2011)
    “…The mitochondrial protein apoptosis-inducing factor (AIF) plays a pivotal role in poly(ADP-ribose) polymerase-1 (PARP-1)-mediated cell death (parthanatos),…”
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  20. 20

    Low cost and massively parallel force spectroscopy with fluid loading on a chip by Akbari, Ehsan, Shahhosseini, Melika, Robbins, Ariel, Poirier, Michael G., Song, Jonathan W., Castro, Carlos E.

    Published in Nature communications (10-11-2022)
    “…Current approaches for single molecule force spectroscopy are typically constrained by low throughput and high instrumentation cost. Herein, a low-cost, high…”
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