Search Results - "Pohla, H."

311: A CXCR4-positive subpopulation exhibits cancer stem cell properties in renal cell carcinoma by Zimmermann, W, Gassenmaier, M, Chen, D, Buchner, A, Pohla, H

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Allogeneic gene-modified tumor cells (RCC-26 IL-7 CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study by Westermann, J, Flörcken, A, Willimsky, G, van Lessen, A, Kopp, J, Takvorian, A, Jöhrens, K, Lukowsky, A, Schönemann, C, Sawitzki, B, Pohla, H, Frank, R, Dörken, B, Schendel, D J, Blankenstein, T, Pezzutto, A

“…Despite novel targeted agents, prognosis of metastatic renal cell cancer (RCC) remains poor, and experimental therapeutic strategies are warranted…”
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Lysis of Prostate Carcinoma Cells by Trifunctional Bispecific Antibodies ({{alpha}}EpCAM {{alpha}}CD3) by Riesenberg, Rainer, Buchner, Alexander, Pohla, Heike, Lindhofer, Horst

“…Bispecific monoclonal antibodies (bsAbs) are a promising immunotherapeutic option for treatment of cancer, especially in situations of minimal residual…”
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Allogeneic retrovirally transduced, IL-2- and IFN-γ-secreting cancer cell vaccine in patients with hormone refractory prostate cancer-a phase I clinical trial by Brill, T. H., Kübler, H. R., Randenborgh, H. v., Fend, F., Pohla, H., Breul, J., Hartung, R., Paul, R., Schendel, D. J., Gansbacher, B.

“…Background The purpose of this vaccine study was to determine the safety and feasibility of vaccination with an allogeneic prostate carcinoma cell line, LNCaP,…”
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Immunomagnetic cell enrichment detects more disseminated cancer cells than immunocytochemistry in vitro by Zigeuner, R E, Riesenberg, R, Pohla, H, Hofstetter, A, Oberneder, R

“…We describe a method to improve tumor cell detection compared to currently available immunocytochemical methods by using immunomagnetic cell enrichment. Two…”
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Expression of B7.1 (CD80) in a renal cell carcinoma line allows expansion of tumor-associated cytotoxic T lymphocytes in the presence of an alloresponse by SCHENDEL, D. J, FRANKENBERGER, B, JANTZER, P, CAYEUX, S, NÖSSNER, E, WILLIMSKY, G, MAGET, B, POHLA, H, BLANKENSTEIN, T

“…We have selected a well-characterized human renal cell carcinoma (RCC) line as the basis for development of a genetically engineered tumor cell vaccine to be…”
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Allogeneic vaccination for renal cell carcinoma: development and monitoring by Pohla, H, Frankenberger, B, Stadlbauer, B, Oberneder, R, Hofstetter, A, Willimsky, G, Pezzutto, A, Dörken, B, Blankenstein, T, Schendel, D J

“…An allogeneic tumor cell vaccine should display a natural immunogenicity that allows the stimulation of tumor-reactive effector cells in patients. Furthermore,…”
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Cytotoxic Markers and Frequency Predict Functional Capacity of Natural Killer Cells Infiltrating Renal Cell Carcinoma by SCHLEYPEN, Julia S, BAUR, Nicole, FALK, Christine S, NOESSNER, Elfriede, KAMMERER, Robert, NELSON, Peter J, ROHRMANN, Karl, CRÖNE, Elisabeth F, HOHENFELLNER, Markus, HAFERKAMP, Axel, POHLA, Heike, SCHENDEL, Dolores J

“…Purpose: Renal cell carcinoma harbors high numbers of infiltrating lymphocytes with apparent limited efficacy in tumor control. This study focused on the…”
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Adoptive tumor therapy with T lymphocytes enriched through an IFN-γ capture assay by Blankenstein, Thomas, Becker, Christian, Pohla, Heike, Frankenberger, Bernhard, Schüler, Thomas, Assenmacher, Mario, Schendel, Dolores J

“…Successful adoptive T-cell therapy has been demonstrated in viral disease and selected forms of cancer. However, it is limited by the difficulty to efficiently…”
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49 THERAPEUTIC VACCINATION IN PATIENTS WITH ANDROGEN-INDEPENDENT PROSTATE CANCER - RESULTS OF AN OPEN-LABELED PHASE I/II TRIAL WITH AN IL2-IFN-Y SECRETING ALLOGENEIC TUMORVACCINE by Kuebler, H.R, Brill, T, Van Randenborgh, H, Paul, R, Fend, F, Pohla, H, Schendel, D.J, Hartung, R, Gansbacher, B

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Isolation of circulating cancer cells from whole blood by immunomagnetic cell enrichment and unenriched immunocytochemistry in vitro by Zigeuner, Richard E, Riesenberg, Rainer, Pohla, Heike, Hofstetter, Alfons, Oberneder, Ralph

“…We improved tumor cell detection compared with currently available immunocytochemical methods by immunomagnetic cell enrichment. Two methods of immunomagnetic…”
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Renal cell carcinoma‐infiltrating natural killer cells express differential repertoires of activating and inhibitory receptors and are inhibited by specific HLA class I allotypes by Schleypen, Julia S., von Geldern, Marion, Weiß, Elisabeth H., Kotzias, Nicole, Rohrmann, Karl, Schendel, Dolores J., Falk, Christine S., Pohla, Heike

“…Among tumor‐infiltrating lymphocytes (TILs) directly isolated from renal cell carcinomas (RCCs), we found substantial numbers of natural killer (NK) cells in…”
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Extrathymic development and function of human T-lymphocytes from bone marrow cells in vitro by Adibzadeh, M, Bühring, H J, Daikeler, T, Siegels-Hübenthal, P, Owsianowsky, M, Schenk, A, Rehbein, A, Schaudt, K, Schlotz, E, Pohla, H

“…To enrich low-density human bone marrow (BM) cells for putative progenitors of T-lymphocytes, CD7+ CD3- cells were sorted (purity was estimated at > 99.9%) and…”
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RNA Transfer by Electroporation into Mature Dendritic Cells Leading to Reactivation of Effector-Memory Cytotoxic T Lymphocytes: A Quantitative Analysis by Javorovic, Miran, Pohla, Heike, Frankenberger, Bernhard, Wölfel, Thomas, Schendel, Dolores J

“…Previous studies have analyzed transfer of RNA-encoded tumor-associated antigens (TAAs) into immature dendritic cells (DCs) because of their exceptional…”
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Phase 1 trial of allogeneic gene-modified tumor cell vaccine RCC-26/CD80/IL-2 in patients with metastatic renal cell carcinoma by Buchner, Alexander, Pohla, Heike, Willimsky, Gerald, Frankenberger, Bernhard, Frank, Ronald, Baur-Melnyk, Andrea, Siebels, Michael, Stief, Christian G, Hofstetter, Alfons, Kopp, Joachim, Pezzutto, Antonio, Blankenstein, Thomas, Oberneder, Ralph, Schendel, Dolores J

“…Preclinical studies showed that the allogeneic tumor cell line RCC-26 displayed natural immunogenic potential that was enhanced through expression of CD80…”
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Role of three quantitatively dominant endogenous peptides from HLA-DRB10401 molecules in class II specific alloreactivity by Adibzadeh, M, Friccius, H, Bornhak, S, Max, H, Hambrecht, A, Sansom, D, Kalbacher, H, Schenk, A, Pohla, H, Pawelec, G

“…Alloreactivity remains an important barrier to organ transplantation and is caused by T cell recognition of foreign histocompatibility antigens (HAg) in two…”
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970 ALLOGENEIC GENETICALLY-MODIFIED TUMOR CELL VACCINE (RCC-26/CD80/IL-2) IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA - A PHASE I TRIAL by Buchner, A, Pohla, H, Baur, A, Kopp, J, Pezzutto, A, Blankenstein, T, Schendel, D, Stief, C, Hofstetter, A, Oberneder, R

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The effects of the antifungal azoles itraconazole, fluconazole, ketoconazole and miconazole on cytokine gene expression in human lymphoid cells by Friccius, H, Pohla, H, Adibzadeh, M, Siegels-Hübenthal, P, Schenk, A, Pawelec, G

“…The antifungal azole drugs itraconazole (itra; R51,211), fluconazole (flu; UK-49,858), ketoconazole (keto) and micronazole (mico) have been investigated for…”
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HSP expression in human leukocytes is modulated by endurance exercise by FEHRENBACH, E, PASSEK, F, NIESS, A. M, POHLA, H, WEINSTOCK, C, DICKHUTH, H.-H, NORTHOFF, H

“…Temperature increase, oxidative stress, and inflammatory reactions after endurance exercise were expected to stimulate the synthesis of heat shock proteins…”
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A PCR-SSP method to specifically select HLA-A0201 individuals for immunotherapeutic studies by Gatz, S.A., Pohla, H., Schendel, D.J.

“…: HLA‐A*0201 is an important restriction element for peptide presentation to T cells in disease and cancer. Mutation studies and analyses using cytotoxic T…”
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