Search Results - "Pogam, Carole Le"

BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome by Gorombei, Petra, Guidez, Fabien, Ganesan, Saravanan, Chiquet, Mathieu, Pellagatti, Andrea, Goursaud, Laure, Tekin, Nilgun, Beurlet, Stephanie, Patel, Satyananda, Guerenne, Laura, Le Pogam, Carole, Setterblad, Niclas, de la Grange, Pierre, LeBoeuf, Christophe, Janin, Anne, Noguera, Maria-Elena, Sarda-Mantel, Laure, Merlet, Pascale, Boultwood, Jacqueline, Konopleva, Marina, Andreeff, Michael, West, Robert, Pla, Marika, Adès, Lionel, Fenaux, Pierre, Krief, Patricia, Chomienne, Christine, Omidvar, Nader, Padua, Rose Ann

“…During transformation, myelodysplastic syndromes (MDS) are characterized by reducing apoptosis of bone marrow (BM) precursors. Mouse models of high risk…”
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GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways by Guerenne, Laura, Beurlet, Stéphanie, Said, Mohamed, Gorombei, Petra, Le Pogam, Carole, Guidez, Fabien, de la Grange, Pierre, Omidvar, Nader, Vanneaux, Valérie, Mills, Ken, Mufti, Ghulam J, Sarda-Mantel, Laure, Noguera, Maria Elena, Pla, Marika, Fenaux, Pierre, Padua, Rose Ann, Chomienne, Christine, Krief, Patricia

“…In spite of the recent discovery of genetic mutations in most myelodysplasic (MDS) patients, the pathophysiology of these disorders still remains poorly…”
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BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells by Beurlet, Stephanie, Omidvar, Nader, Gorombei, Petra, Krief, Patricia, Le Pogam, Carole, Setterblad, Niclas, de la Grange, Pierre, Leboeuf, Christophe, Janin, Anne, Noguera, Maria-Elena, Hervatin, Florence, Sarda-Mantel, Laure, Konopleva, Marina, Andreeff, Michael, Tu, Andrea W., Fan, Alice C., Felsher, Dean W., Whetton, Anthony, Pla, Marika, West, Robert, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann

“…Myelodysplastic syndrome (MDS) transforms into an acute myelogenous leukemia (AML) with associated increased bone marrow (BM) blast infiltration. Using a…”
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Tracking the Extramedullary PML-RARα-Positive Cell Reservoirs in a Preclinical Model of APL: Biomarker of Long-Term Drug Efficacy by Pokorna, Katerina, Le Pogam, Carole, Chopin, Martine, Cassinat, Bruno, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann, Pla, Marika

“…Abstract 1510 Relapses are now relatively rare in APL and occur mainly in the bone marrow (BM) within 3 years of complete response achievement, but later BM…”
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pVAX14 DNA, a Non-Specific DNA Vaccine, Improves Survival In An Acute Promyelocytic Leukemia (APL) Mouse Model Treated With All-Trans Retinoic Acid (ATRA) and Arsenic Trioxide (ATO) and Targets Leukemia Initiating Cells (LICs) by Patel, Satyananda, Guerenne, Laura, Le Pogam, Carole, Gorombei, Petra, Krief, Patricia, Schlageter, Marie-Helene, West, Robert, Mathews, Vikram, Pla, Marika, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann

“…The combination of ATRA and ATO is very effective in treating APL, both in mouse models (Lallemand JEM 1999) and in patients (Lo Coco NEJM 2013). Having…”
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pVAX14 DNA, An Immunoadjuvant, Extends Life-Span As Add-On Treatment To Azacitidine (AZA) In A Mouse Model Of High Risk Myelodysplastic Syndrome (HR-MDS) by Petra, Gorombei, Carole, Le Pogam, Krief, Patricia, Patel, Satyananda, Laura, Guerenne, Robert, West, Marika, Pla, Pierre, Fenaux, Christine, Chomienne, Padua, Rose Ann

“…We have established animal models of MDS and acute myelogenous leukemia (AML) using NRASD12 and overexpression of BCL-2 (Omidvar Cancer Res 2007). These models…”
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Efficacy of ABT-737, a BCL-2 Inhibitor, in an NRAS/BCL2 Mouse Model of High Risk Myelodysplasia (HR-MDS) By Targeting Pathways Identified By Gene Expression Profiling by Padua, Rose Ann, Gorombei, Petra, Beurlet, Stéphanie, Omidvar, Nader, Patel, Satyananda, Guerenne, Laura, Le Pogam, Carole, Setterblad, Niclas, de la Grange, Pierre, Guidez, Fabien, Le Boeuf, Christophe, Janin, Anne, Noguera, Maria-Elena, Sarda-Mantel, Laure, Merlet, Pascal, West, Robert, Pla, Marika, Fenaux, Pierre, Krief, Patricia, Chomienne, Christine

“…Background: MDS lack therapeutic approaches in many instances and very few animal models of MDS available for preclinical testing of new drugs have been…”
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Tracking the extramedullary PML-RARα-positive cell reservoirs in a preclinical model: Biomarker of long-term drug efficacy by Pokorna, Katerina, Le Pogam, Carole, Chopin, Martine, Balitrand, Nicole, Reboul, Murielle, Cassinat, Bruno, Chomienne, Christine, Padua, Rose Ann, Pla, Marika

“…Using an acute promyelocytic leukemia (APL) preclinical model, we show that oncogene–specific PCR (Polymerase Chain Reaction)-based assays allow to evaluate…”
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BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia by OMIDVAR, Nader, KOGAN, Scott, SETTERBLAD, Niclas, FELSHER, Dean, LAGASSE, Eric, MOHAMEDALI, Azim, THOMAS, N. Shaun B, FENAUX, Pierre, FONTENAY, Michaela, PLA, Marika, MUFTI, Ghulam J, WEISSMAN, Irving, BEURLET, Stephanie, CHOMIENNE, Christine, PADUA, Rose Ann, LE POGAM, Carole, JANIN, Anne, WEST, Robert, NOGUERA, Maria-Elena, REBOUL, Murielle, SOULIE, Annie, LEBOEUF, Christophe

“…Myelodysplastic syndromes (MDS) are clonal stem cell hematologic disorders that evolve to acute myeloid leukemia (AML) and thus model multistep leukemogenesis…”
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DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies by Le Pogam, Carole, Patel, Satyananda, Gorombei, Petra, Guerenne, Laura, Krief, Patricia, Omidvar, Nader, Tekin, Nilgun, Bernasconi, Elena, Sicre, Flore, Schlageter, Marie-Helene, Chopin, Martine, Noguera, Maria-Elena, West, Robert, Abu, Ansu, Mathews, Vikram, Pla, Marika, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann

“…We have previously shown that a specific promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) DNA vaccine combined with all-trans retinoic acid…”
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BCL-2 Inhibition with ABT-737 Prolongs Survival in an NRAS/BCL2-Mediated MOUSE MODEL of Myelodyspastic Syndrome (MDS) Progressing to ACUTE Myelogenous Leukemia (AML) by Targeting Leukemia Initiating CELLS by Gorombei, Petra, Stephanie, Beurlet, Omidvar, Nader, Patricia, Krief, Carole, Le Pogam, de la Grange, Pierre, Christophe, Leboeuf, Janin, Anne, Maria-Elena, Noguera, Konopleva, Marina, Andreeff, Michael, Marika, Pla, Robert, West, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann

“…Abstract 678 BCL-2 activation plays a role in the progression of MDS to AML and BCL 2 inhibition may represent a therapeutic target in such patients. Using our…”
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DNA vaccination with all-trans retinoic acid treatment induces long-term survival and elicits specific immune responses requiring CD4+ and CD8+ T-cell activation in an acute promyelocytic leukemia mouse model by Furugaki, Kouichi, Pokorna, Katerina, Le Pogam, Carole, Aoki, Masayuki, Reboul, Murielle, Bajzik, Véronique, Krief, Patricia, Janin, Anne, Noguera, Marie-Elena, West, Robert, Charron, Dominique, Chomienne, Christine, Pla, Marika, Moins-Teisserenc, Hélène, Padua, Rose Ann

“…DNA vaccination and all-trans retinoic acid (ATRA) result in a survival advantage in a mouse model of acute promyelocytic leukemia (APL). Depletion of CD4+ or…”
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Mutant BCL2 Co-Operates with CBFβ/PEBP2β-MYH11 to Promote Expansion of Leukemia Initiating Cells with a Predominantly Pro-Apoptotic Mechanism Via Recruitment of Ras-GTP In a Mouse Model of Progressive Acute Myeloid Leukemia by Omidvar, Nader, Pogam, Carole Le, Beurlet, Stephanie, Noguera, Maria-Elena, Janin, Ann, Kogan, Scott C., Weissman, Irving L., Pla, Marika, Chomienne, Christine, Padua, Rose Ann

“…Abstract 1050 Mutations and translocation of the core binding factor complexes frequently co-operate with other lesions in Acute Myeloid Leukemia (AML). In…”
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DNA and All-Trans Retinoic Acid as Immunotherapy or Add-on Adjuvants to 5-Azacytidine In Myelodysplastic Syndromes by Le Pogam, Carole, Krief, Patricia, Beurlet, Stéphanie, Reboul, Murielle, West, Robert, Pla, Marika, Charron, Dominique, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann

“…Abstract 2938 Myelodysplastic syndromes (MDS) are clonal stem cell hematological disorders characterized by ineffective hematopoiesis leading to cytopenia,…”
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NRAS:BCL-2 Complex Localization Determines Anti-Apoptotic Features Associated with Progressive Disease in Myelodysplastic Syndromes (MDS) by Padua, Rose Ann, Le Pogam, Carole, Krief, Patricia, Beurlet, Stephanie, Cassinat, Bruno, Cavé, Hélène, Kosmider, Olivier, Setterblad, Niclas, Leboeuf, Christophe, Sarda-Mantel, Laure, Hervatin, Florence, Merlet, Pascal, Noguera, Maria-Elena, Janin, Anne, Pla, Marika, Fontenay, Michaela, Ades, Lionel, Fenaux, Pierre, Chomienne, Christine, Omidvar, Nader

“…Abstract 3835 Activation of the RAS pathway plays an important role in the pathogenesis of myeloid malignancies. RAS mutations occur in some 10% of MDS and…”
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Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes by Le Pogam, Carole, Krief, Patricia, Beurlet, Stephanie, Soulié, Annie, Balitrand, Nicole, Cassinat, Bruno, Cavé, Helene, Kosmider, Olivier, Setterblad, Niclas, Leboeuf, Christophe, Sarda-Mantel, Laure, Hervatin, Florence, Merlet, Pascal, Noguera, Maria-Elena, Janin, Anne, Pla, Marika, Fontenay, Michaela, Adès, Lionel, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann, Omidvar, Nader

“…Abstract We have previously demonstrated that two prognostic features of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML), mutant NRAS and…”
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ABT-737 Targets Leukemic Stem Cells In Mouse Models of Mutant NRASD12/hBCL-2- Mediated Acute Myeloid Leukemia Progression with Increased Survival by Padua, Rose Ann, Beurlet, Stephanie, Krief, Patricia, Omidvar, Nader, Pogam, Carole Le, Auboeuf, Didier, de la Grange, Pierre, Soulie, Annie, Janin, Anne, Noguera, Maria-Elena, Merlet, Pascal, Sarda-Mantel, Laure, Fenaux, Pierre, Konopleva, Marina, Andreeff, Michael, Tu, Andrea, Yang, Phoebe, Fan, Alice C., Kogan, Scott C., Weissman, Irving L., Felsher, Dean W., Pla, Marika, West, Robert, Chomienne, Christine

“…Abstract 3308 Animal models enable us to understand disease progression and provide us with reagents to test various therapeutic strategies. We have previously…”
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DNA Vaccination and All-Trans Retinoic Acid Treatment-Induced Long Term Survival Requires CD4+ and CD8+ T-Cell Activation in An APL Mouse Model by Padua, Rose Ann, Furugaki, Kouichi, Moins-Teisserenc, Helene, Pokorna, Katerina, Le Pogam, Carole, Reboul, Murielle, Aoki, Masayuki, Bajzik, Veronique, Krief, Patricia, Janin, Anne, Noguera, Maria-Elena, West, Robert, Schlageter, Marie-Helene, Charron, Dominique, Pla, Marika, Chomienne, Christine

“…OBJECTIVES: DNA vaccines can be effective in the acquisition of humoral and cellmediated immune responses. Our studies on an acute promyelocytic leukemia (APL)…”
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ABT-737 Targets Intrinsic Apoptosis during Cooperation of BCL-2 and Oncogenic NRAS in An in Vivo Progression Model of Myelodysplasia/Acute Myeloid Leukaemia by Omidvar, Nader, Beurlet, Stephanie, Le Pogam, Carole, Janin, Anne, Leboeuf, Christophe, Soulie, Annie, Setterblad, Niclas, Noguera, Maria-Elena, Sarda-Mantel, Laure, Merlet, Pascal, Pla, Marika, Kogan, Scott C., Weissman, Irving L, Konopleva, Marina, Bormann, William, Andreeff, Michael, Chomienne, Christine, Padua, Rose Ann

“…OBJECTIVES: Activating RAS mutations and over-expression of BCL-2 are prognostic features of myelodysplastic syndromes/acute myeloid leukemia (MDS/AML)…”
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Retinoic acid receptor α1 variants, RARα1ΔB and RARα1ΔBC, define a new class of nuclear receptor isoforms by Parrado, Antonio, Despouy, Gilles, Kraïba, Radhia, Pogam, Carole Le, Dupas, Stéphane, Choquette, Maryline, Robledo, Macarena, Larghero, Jérôme, Bui, Hung, Gall, Isabelle Le, Rochette-Egly, Cécile, Chomienne, Christine, Padua, Rose Ann

“…Retinoic acid (RA) binds and activates retinoid X receptor (RXR)/retinoic acid receptor (RAR) heterodimers, which regulate the transcription of genes that have…”
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