Search Results - "Pofahl, Ruth"

Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis by Deshmukh, Jayesh, Pofahl, Ruth, Haase, Ingo

“…Non-melanoma skin cancer (NMSC) is the most common type of cancer. Increased expression and activity of Rac1, a small Rho GTPase, has been shown previously in…”
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Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1 by Tscharntke, Michael, Pofahl, Ruth, Chrostek-Grashoff, Anna, Smyth, Neil, Niessen, Carien, Niemann, Catherin, Hartwig, Benedikt, Herzog, Volker, Klein, Helmut W, Krieg, Thomas, Brakebusch, Cord, Haase, Ingo

“…To address the functions of Rac1 in keratinocytes of the basal epidermal layer and in the outer root sheath of hair follicles, we generated transgenic mice…”
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Localized Inflammatory Skin Disease Following Inducible Ablation of I Kappa B Kinase 2 in Murine Epidermis by Stratis, Athanasios, Pasparakis, Manolis, Markur, Doreen, Knaup, Renate, Pofahl, Ruth, Metzger, Daniel, Chambon, Pierre, Krieg, Thomas, Haase, Ingo

“…Skin inflammation is a complex process that involves interactions between various cell types residing in different skin compartments. Using mice with…”
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Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis by Deshmukh, Jayesh, Pofahl, Ruth, Pfister, Herbert, Haase, Ingo

“…Overexpression and increased activity of the small Rho GTPase Rac1 has been linked to squamous cell carcinoma of the epidermis and mucosa in humans. Targeted…”
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Epidermal RelA Specifically Restricts Contact Allergen–Induced Inflammation and Apoptosis in Skin by Kumari, Snehlata, Herzberg, Benjamin, Pofahl, Ruth, Krieg, Thomas, Haase, Ingo

“…Strong inhibition of NF-κB signaling in the epidermis results in spontaneous skin inflammation in mice and men. As there is evidence for linkage between…”
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Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways by Haase, Ingo, Evans, Richard, Pofahl, Ruth, Watt, Fiona M

“…Adult epidermal keratinocytes migrate by crawling, a process that requires protrusion of the plasma membrane at the front of the cell and contraction of the…”
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A function for Rac1 in the terminal differentiation and pigmentation of hair by Behrendt, Kristina, Klatte, Jennifer, Pofahl, Ruth, Bloch, Wilhelm, Smyth, Neil, Tscharntke, Michael, Krieg, Thomas, Paus, Ralf, Niessen, Carien, Niemann, Catherin, Brakebusch, Cord, Haase, Ingo

“…The small GTPase Rac1 is ubiquitously expressed in proliferating and differentiating layers of the epidermis and hair follicles. Previously, Rac1 was shown to…”
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A function for Rac1 in the terminal differentiation and pigmentation of hair by Behrendt, Kristina, Klatte, Jennifer, Pofahl, Ruth, Bloch, Wilhelm, Smyth, Neil, Tscharntke, Michael, Krieg, Thomas, Paus, Ralf, Niessen, Carien, Niemann, Catherin, Brakebusch, Cord, Haase, Ingo

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Enhanced contact allergen- and UVB-induced keratinocyte apoptosis in the absence of CD95 Fas Apo-1 by Hedrych-Ozimina, A, Behrendt, K, Hao, Z, Pofahl, R, Ussath, D, Knaup, R, Krieg, T, Haase, I

“…FAS/CD95/Apo-1 is a ubiquitously expressed cell-surface receptor involved in the initiation of programmed cell death. Its function in epidermal keratinocytes…”
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Ras-induced spreading and wound closure in human epidermal keratinocytes by Tscharntke, Michael, Pofahl, Ruth, Krieg, Thomas, Haase, Ingo

“…ABSTRACTAlthough it is known that growth factor signaling cascades are active during epithelial wound healing, signals that regulate reepithelialization after…”
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