Search Results - "Poetsch, Anna R."

The genomics of oxidative DNA damage, repair, and resulting mutagenesis by Poetsch, Anna R.

“…[Display omitted] Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of disrupting genome function, inducing genome…”
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Target-Specific Precision of CRISPR-Mediated Genome Editing by Chakrabarti, Anob M., Henser-Brownhill, Tristan, Monserrat, Josep, Poetsch, Anna R., Luscombe, Nicholas M., Scaffidi, Paola

“…The CRISPR-Cas9 system has successfully been adapted to edit the genome of various organisms. However, our ability to predict the editing outcome at specific…”
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Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis by Poetsch, Anna R, Boulton, Simon J, Luscombe, Nicholas M

“…DNA is subject to constant chemical modification and damage, which eventually results in variable mutation rates throughout the genome. Although detailed…”
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Distinguishing word identity and sequence context in DNA language models by Sanabria, Melissa, Hirsch, Jonas, Poetsch, Anna R

“…Transformer-based large language models (LLMs) are very suited for biological sequence data, because of analogies to natural language. Complex relationships…”
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NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity by Kilgas, Susan, Syed, Aleem, Toolan-Kerr, Patrick, Swift, Michelle L., Roychoudhury, Shrabasti, Sarkar, Aniruddha, Wilkins, Sarah, Quigley, Mikayla, Poetsch, Anna R., Botuyan, Maria Victoria, Cui, Gaofeng, Mer, Georges, Ule, Jernej, Drané, Pascal, Chowdhury, Dipanjan

“…Tudor Interacting Repair Regulator (TIRR) is an RNA-binding protein (RBP) that interacts directly with 53BP1, restricting its access to DNA double-strand…”
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Transcriptional regulation by DNA methylation by Poetsch, Anna R, Plass, Christoph

“…Abstract Epigenetic mechanisms synergize with genetic alterations in modulating gene expression patterns in cancer cells. While epigenetic alterations are…”
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Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation by Blake, Sophia M, Stricker, Stefan H, Halavach, Hanna, Poetsch, Anna R, Cresswell, George, Kelly, Gavin, Kanu, Nnennaya, Marino, Silvia, Luscombe, Nicholas M, Pollard, Steven M, Behrens, Axel

“…Glioblastoma multiforme (GBM) is the most aggressive human primary brain cancer. Using a Trp53-deficient mouse model of GBM, we show that genetic inactivation…”
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AP-Seq: A Method to Measure Apurinic Sites and Small Base Adducts Genome-Wide by Poetsch, Anna R

“…DNA is constantly challenged by chemical modification and spontaneous loss of its bases, which results in apurinic sites (AP-sites). In addition to the direct…”
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Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation by Shirai, Hidenori, Fujimori, Hiroaki, Gunji, Akemi, Maeda, Daisuke, Hirai, Takahisa, Poetsch, Anna R., Harada, Hiromi, Yoshida, Tomoko, Sasai, Keisuke, Okayasu, Ryuichi, Masutani, Mitsuko

“…•Parg−/− ES cells were more sensitive to γ-irradiation than Parp-1−/− ES cells.•Parg−/− cells were more sensitive to carbon-ion irradiation than Parp-1−/−…”
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AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation by Ghodke, Indrajeet, Remisova, Michaela, Furst, Audrey, Kilic, Sinan, Reina-San-Martin, Bernardo, Poetsch, Anna R., Altmeyer, Matthias, Soutoglou, Evi

“…p53-binding protein 1 (53BP1) regulates both the DNA damage response and p53 signaling. Although 53BP1’s function is well established in DNA double-strand…”
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Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19 by Bernardes, Joana P., Tran, Florian, Best, Lena, Bordoni, Dora, Josephs-Spaulding, Jonathan, Köhler, Philipp, Künstner, Axel, Rosati, Elisa, Bacher, Petra, Bruse, Niklas, Franzenburg, Sören, Frey, Norbert, Fuß, Janina, Glück, Andreas, Hamm, Jacob, Imm, Simon, Kaiser, Sina, Lange, Christoph, Laue, Georg, Marinos, Georgios, Pickkers, Peter, Rabe, Klaus F., Renz, Alina, Röcken, Christoph, Rupp, Jan, Schaffarzyk, Annika, Scheffold, Alexander, Schulte-Schrepping, Jonas, Skowasch, Dirk, Ulas, Thomas, Wandinger, Klaus-Peter, Wittig, Michael, Zimmermann, Johannes, Busch, Hauke, Hoyer, Bimba F., Kaleta, Christoph, Heyckendorf, Jan, Rybniker, Jan, Schultze, Joachim L., Rosenstiel, Philip, Banovich, Nicholas E., Desai, Tushar, Eickelberg, Oliver, Haniffa, Muzlifa, Horvath, Peter, Kropski, Jonathan A., Lafyatis, Robert, Meyer, Kerstin, Nawijn, Martijn C., Nikolic, Marko, Ordovas Montanes, Jose, Pe’er, Dana, Tata, Purushothama Rao, Rawlins, Emma, Regev, Aviv, Reyfman, Paul, Samakovlis, Christos, Schultze, Joachim, Shalek, Alex, Shepherd, Douglas, Spence, Jason, Theis, Fabian, van den Berge, Maarten, von Papen, Michael, Whitsett, Jeffrey, Angelov, Angel, Bals, Robert, Bonifacio, Ezio, Colme-Tatche, Maria, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Gagneur, Julien, Goesmann, Alexander, Kallies, René, Kehr, Birte, Keller, Andreas, Kim-Hellmuth, Sarah, Korbel, Jan O., Kurth, Ingo, Landthaler, Markus, Li, Yang, Ludwig, Kerstin, Makarewicz, Oliwia, Nöthen, Markus, Nürnberg, Peter, Ohler, Uwe, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Poetsch, Anna R., Rajewsky, Niklaus, Ralser, Markus, Saliba, Antoine-Emmanuel, Schulte, Eva-Christina, Sczyrba, Alexander, Stegle, Oliver, Stoye, Jens, von Kleist, Max, Walker, Andreas

“…Temporal resolution of cellular features associated with a severe COVID-19 disease trajectory is needed for understanding skewed immune responses and defining…”
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Insulin-like Growth Factor-II Methylation Status in Lymphocyte DNA and Colon Cancer Risk in the Northern Sweden Health and Disease Cohort by KAAKS, Rudolf, STATTIN, Pär, FRIESEN, Marlin D, VILLA, Stéphanie, POETSCH, Anna R, DOSSUS, Laure, NIETERS, Alexandra, RIBOLI, Elio, PALMQVIST, Richard, HALLMANS, Göran, PLASS, Christoph

“…Loss of imprinting (LOI) of the insulin-like growth factor II (IGFII) gene is a frequent phenomenon in colorectal tumor tissues. Previous reports indicated…”
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RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions by Kotsantis, Panagiotis, Segura-Bayona, Sandra, Margalef, Pol, Marzec, Paulina, Ruis, Phil, Hewitt, Graeme, Bellelli, Roberto, Patel, Harshil, Goldstone, Robert, Poetsch, Anna R., Boulton, Simon J.

“…Regulator of telomere length 1 (RTEL1) is an essential helicase that maintains telomere integrity and facilitates DNA replication. The source of replication…”
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Detection and Monitoring of Lineage-Specific Chimerism by Digital Droplet PCR-Based Testing of Deletion/Insertion Polymorphisms by Fortschegger, Michaela, Preuner, Sandra, Printz, Dieter, Poetsch, Anna R., Geyeregger, René, Pichler, Herbert, Lawitschka, Anita, Lion, Thomas

“…•Analysis of deletion/insertion polymorphisms (DIPs) by digital droplet (dd) PCR represents a powerful technique for the sensitive and quantitative detection…”
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Phylogenetic analysis of SARS-CoV-2 lineage development across the first and second waves in Eastern Germany in 2020: insights into the cause of the second wave by Yi, Buqing, Poetsch, Anna R., Stadtmüller, Marlena, Rost, Fabian, Winkler, Sylke, Dalpke, Alexander H.

“…In Germany, Eastern regions had a mild first wave of coronavirus disease 2019 (COVID-19) from March to May 2020, but were badly hit by a second wave later in…”
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DNA language model GROVER learns sequence context in the human genome by Sanabria, Melissa, Hirsch, Jonas, Joubert, Pierre M., Poetsch, Anna R.

“…Deep-learning models that learn a sense of language on DNA have achieved a high level of performance on genome biological tasks. Genome sequences follow rules…”
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Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Clusters Based on Integrated Genomic Surveillance, Outbreak Analysis and Contact Tracing in an Urban Setting by Walker, Andreas, Houwaart, Torsten, Finzer, Patrick, Ehlkes, Lutz, Tyshaieva, Alona, Damagnez, Maximilian, Strelow, Daniel, Duplessis, Ashley, Nicolai, Jessica, Wienemann, Tobias, Tamayo, Teresa, Kohns Vasconcelos, Malte, Hülse, Lisanna, Hoffmann, Katrin, Lübke, Nadine, Hauka, Sandra, Andree, Marcel, Däumer, Martin P, Thielen, Alexander, Kolbe-Busch, Susanne, Göbels, Klaus, Zotz, Rainer, Pfeffer, Klaus, Timm, Jörg, Dilthey, Alexander T

“…Abstract Background Tracing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission chains is still a major challenge for public health…”
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Evaluation of circulating Dickkopf-1 as a prognostic biomarker in ovarian cancer patients by Klotz, Daniel Martin, Link, Theresa, Goeckenjan, Maren, Wimberger, Pauline, Poetsch, Anna R, Jaschke, Nikolai, Hofbauer, Lorenz C, Göbel, Andy, Rachner, Tilman D, Kuhlmann, Jan Dominik

“…Dickkopf-1 (DKK1) is a secreted protein, known for suppressing the differentiation and activity of bone-building osteoblasts by acting as an inhibitor of…”
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Deep Learning Improves Pancreatic Cancer Diagnosis Using RNA-Based Variants by Al-Fatlawi, Ali, Malekian, Negin, García, Sebastián, Henschel, Andreas, Kim, Ilwook, Dahl, Andreas, Jahnke, Beatrix, Bailey, Peter, Bolz, Sarah Naomi, Poetsch, Anna R., Mahler, Sandra, Grützmann, Robert, Pilarsky, Christian, Schroeder, Michael

“…For optimal pancreatic cancer treatment, early and accurate diagnosis is vital. Blood-derived biomarkers and genetic predispositions can contribute to early…”
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Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome by Olk-Batz, Christiane, Poetsch, Anna R., Nöllke, Peter, Claus, Rainer, Zucknick, Manuela, Sandrock, Inga, Witte, Tania, Strahm, Brigitte, Hasle, Henrik, Zecca, Marco, Starý, Jan, Bergstraesser, Eva, De Moerloose, Barbara, Trebo, Monika, van den Heuvel-Eibrink, Marry M., Wojcik, Dorota, Locatelli, Franco, Plass, Christoph, Niemeyer, Charlotte M., Flotho, Christian

“…Aberrant DNA methylation contributes to the malignant phenotype in virtually all types of cancer, including myeloid leukemia. We hypothesized that CpG island…”
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