Search Results - "Poet, Torka S"

A human life-stage physiologically based pharmacokinetic and pharmacodynamic model for chlorpyrifos: Development and validation by Smith, Jordan Ned, Hinderliter, Paul M., Timchalk, Charles, Bartels, Michael J., Poet, Torka S.

“…•A life-stage PBPK/PD model for chlorpyrifos was developed.•Simulations predict adults will have higher chlorpyrifos levels in blood.•At doses ⩾0.6mg/kg,…”
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In Vitro Age-Dependent Enzymatic Metabolism of Chlorpyrifos and Chlorpyrifos-Oxon in Human Hepatic Microsomes and Chlorpyrifos-Oxon in Plasma by NED SMITH, Jordan, TIMCHALK, Charles, BARTELS, Michael J, POET, Torka S

“…Age-dependent chlorpyrifos (CPF) metabolism was quantified by in vitro product formation in human hepatic microsomes (ages 13 days to 75 years) and plasma…”
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Development of a source-to-outcome model for dietary exposures to insecticide residues: An example using chlorpyrifos by Hinderliter, Paul M., Price, Paul S., Bartels, Michael J., Timchalk, Charles, Poet, Torka S.

“…► Source-to-outcome model for inter-individual variation at dietary dose levels. ► Differences in physiology and variation in metabolism included at ages 3 and…”
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Quantitative Risk Analysis for N-Methyl Pyrrolidone Using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling by Poet, Torka S., Kirman, Chris R., Bader, Michael, van Thriel, Christoph, Gargas, Michael L., Hinderliter, Paul M.

“…Establishing an occupational exposure limit (OEL) for N-methyl pyrrolidone (NMP) is important due to its widespread use as a solvent. Based on studies in…”
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The Effect of Plasma Lipids on the Pharmacokinetics of Chlorpyrifos and the Impact on Interpretation of Blood Biomonitoring Data by Lowe, Ezra R., Poet, Torka S., Rick, David L., Marty, M. Sue, Mattsson, Joel L., Timchalk, Charles, Bartels, Michael J.

“…Lipophilic molecules, like chlorpyrifos (CPF), present a special problem for interpretation of biomonitoring data because both the environmental dose of CPF…”
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Physiologically Based Pharmacokinetic Modeling of 1,4-Dioxane in Rats, Mice, and Humans by Sweeney, Lisa M., Thrall, Karla D., Poet, Torka S., Corley, Richard A., Weber, Thomas J., Locey, Betty J., Clarkson, Jacquelyn, Sager, Shawn, Gargas, Michael L.

“…1,4-Dioxane (CAS No. 123-91-1) is used primarily as a solvent or as a solvent stabilizer. It can cause lung, liver, and kidney damage at sufficiently high…”
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In vitro measurements of metabolism for application in pharmacokinetic modeling by Lipscomb, John C, Poet, Torka S

“…Human risk and exposure assessments require dosimetry information. Species-specific tissue dose response will be driven by physiological and biochemical…”
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Chlorpyrifos PBPK/PD model for multiple routes of exposure by Poet, Torka S., Timchalk, Charles, Hotchkiss, Jon A., Bartels, Michael J.

“…Abstract 1. Chlorpyrifos (CPF) is an important pesticide used to control crop insects. Human Exposures to CPF will occur primarily through oral exposure to…”
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Use of a probabilistic PBPK/PD model to calculate Data Derived Extrapolation Factors for chlorpyrifos by Poet, Torka S., Timchalk, Charles, Bartels, Michael J., Smith, Jordan N., McDougal, Robin, Juberg, Daland R., Price, Paul S.

“…A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model combined with Monte Carlo analysis of inter-individual variation was used to assess…”
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An Age-Dependent Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat by Timchalk, Charles, Kousba, Ahmed A., Poet, Torka S.

“…Juvenile rats are more susceptible than adults to the acute toxicity of organophosphorus insecticides like chlorpyrifos (CPF). Age- and dose-dependent…”
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Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat by Smith, Jordan Ned, Campbell, James A, Busby-Hjerpe, Andrea L, Lee, Sookwang, Poet, Torka S, Barr, Dana B, Timchalk, Charles

“…Abstract Chlorpyrifos (CPF) is a commonly used organophosphorus pesticide. A number of toxicity and mechanistic studies have been conducted in animals, where…”
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Age-Related Brain Cholinesterase Inhibition Kinetics following In Vitro Incubation with Chlorpyrifos-Oxon and Diazinon-Oxon by Kousba, Ahmed A., Poet, Torka S., Timchalk, Charles

“…Chlorpyrifos and diazinon are two commonly used organophosphorus insecticides (OPs), and their primary mechanism of action involves the inhibition of…”
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Comparative pharmacokinetics of chlorpyrifos versus its major metabolites following oral administration in the rat by Busby-Hjerpe, Andrea L, Campbell, James A, Smith, Jordan Ned, Lee, Sookwang, Poet, Torka S, Barr, Dana B, Timchalk, Charles

“…Abstract Chlorpyrifos (CPF) is a commonly used diethylphosphorothionate organophosphorus (OP) insecticide. Diethylphosphate (DEP), diethylthiophosphate (DETP)…”
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Application of a source-to-outcome model for the assessment of health impacts from dietary exposures to insecticide residues by Price, Paul S., Schnelle, Karl D., Cleveland, Cheryl B., Bartels, Michael J., Hinderliter, Paul M., Timchalk, Charles, Poet, Torka S.

“…► A PBPK/PD model of chlorpyrifos is used to evaluate dietary exposure in adults and children. ► Modeling allows characterization of health outcomes without…”
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Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats by Lee, Sookwang, Poet, Torka S., Smith, Jordan N., Busby-Hjerpe, Andrea L., Timchalk, Charles

“…Routine use of tobacco products may modify physiological and metabolic functions, including drug metabolizing enzymes, which may impact the pharmacokinetics of…”
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Hydroquinone PBPK model refinement and application to dermal exposure by Poet, Torka S., Carlton, Betsy D., Deyo, James A., Hinderliter, Paul M.

“…A physiologically based pharmacokinetic (PBPK) model for hydroquinone (HQ) was refined to include an expanded description of HQ-glucuronide metabolites and a…”
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Skin absorption and human risk assessment by Poet, Torka S., McDougal, James N.

“…A common practice is to assume that percutaneous absorption does not significantly contribute to total bioavailability and therefore, absorption through other…”
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DETERMINATION OF BIOKINETIC INTERACTIONS IN CHEMICAL MIXTURES USING REAL-TIME BREATH ANALYSIS AND PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING by Thrall, K D, Poet, T S

“…Regulatory agencies are challenged to conduct risk assessments on chemical mixtures without full information on toxicological interactions that may occur at…”
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In vitro glutathione conjugation of methyl iodide in rat, rabbit, and human blood and tissues by Poet, Torka S., Wu, Hong, Corley, Richard A., Thrall, Karla D.

“…Methyl iodide (MeI) is an intermediate in the manufacture of some pesticides and pharmaceuticals, and is under review for US registration as a non-ozone…”
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Noninvasive Biomonitoring Approaches to Determine Dosimetry and Risk Following Acute Chemical Exposure: Analysis of Lead or Organophosphate Insecticide in Saliva by Timchalk, Charles, Poet, Torka S., Kousba, Ahmed A., Campbell, James A., Lin, Yuehe

“…There is a need to develop approaches for assessing risk associated with acute exposures to a broad range of metals and chemical agents and to rapidly…”
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