Search Results - "Poelzl, Andrea"
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Testicular Niche Required for Human Spermatogonial Stem Cell Expansion
Published in Stem cells translational medicine (01-09-2014)“…This study characterizes the cellular niche required for the expansion of human spermatogonial stem cells (SSCs), provides strong evidence supporting specific…”
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Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade
Published in Haematologica (Roma) (01-04-2023)“…Tyrosine kinase 2 (TYK2) is a member of the Janus kinase/signal transducer and activator of transcription pathway, which is central in cytokine signaling…”
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STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity
Published in Frontiers in immunology (11-09-2020)“…Natural killer (NK) cells are important components of the innate immune defense against infections and cancers. Signal transducer and activator of…”
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Effect of Different Ambient Temperatures on Reproductive Outcome and Stress Level of Lactating Females in Two Mouse Strains
Published in Animals (Basel) (20-08-2022)“…Ambient temperature is an important non-biotic environmental factor influencing immunological and oncological parameters in laboratory mice. It is under…”
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TYK2 licenses non-canonical inflammasome activation during endotoxemia
Published in Cell death and differentiation (01-02-2021)“…The non-canonical inflammasome is an emerging crucial player in the development of inflammatory and neurodegenerative diseases. It is activated by direct…”
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Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1
Published in Cell reports (Cambridge) (26-02-2019)“…Cytomegalovirus (CMV) has a high prevalence worldwide, is often fatal for immunocompromised patients, and causes bone marrow suppression. Deficiency of signal…”
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ID: 131: Kinase-independent functions of Tyrosine kinase 2 (Tyk2) contribute to the pathogenesis of lipopolysaccharide (LPS)-induced endotoxemia
Published in Cytokine (Philadelphia, Pa.) (01-11-2015)“…Sepsis is initiated by the presence of bacteria, or their products (e.g. endotoxins), in the bloodstream. It still represents a major problem in health care…”
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