Search Results - "Poel, E."

How did general practices organize care during the COVID-19 pandemic: the protocol of the cross-sectional PRICOV-19 study in 38 countries by Van Poel, E, Vanden Bussche, P, Klemenc-Ketis, Z, Willems, S

“…General practitioners (GPs) play a crucial role in the fight against the COVID-19 pandemic as the first point of contact for possibly infected patients and are…”
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Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies by Bajic, Goran, van der Poel, Cees E., Kuraoka, Masayuki, Schmidt, Aaron G., Carroll, Michael C., Kelsoe, Garnett, Harrison, Stephen C.

“…Epitope-focused approaches for selective clonal induction of broadly neutralizing antibodies (bnAbs) inform most current vaccine strategies for influenza virus…”
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Is there a health penalty of China's rapid urbanization? by Van de Poel, E., O'Donnell, O., Van Doorslaer, E.

“…SUMMARY While highly pertinent to the human welfare consequences of development, the impact of rapid urbanization on population health is not obvious. This…”
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Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease by Akama-Garren, Elliot H., van den Broek, Theo, Simoni, Lea, Castrillon, Carlos, van der Poel, Cees E., Carroll, Michael C.

“…Pathogenic autoantibodies contribute to tissue damage and clinical decline in autoimmune disease. Follicular T cells are central regulators of germinal…”
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[ 18 F]FDG-PET/CT-based risk stratification in women with locally advanced uterine cervical cancer by Adam, J A, Poel, E, van Eck Smit, B L F, Mom, C H, Stalpers, L J A, Laan, J J, Kidd, E, Stoker, J, Bipat, S

“…[ F]FDG-PET/CT is used for staging and treatment planning in patients with locally advanced cervical cancer (LACC). We studied if a PET-based prediction model…”
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Intestinal organoids for Cystic Fibrosis research by de Poel, E., Lefferts, J.W., Beekman, J.M.

“…Significant progress has been made in the development of CFTR modulator therapy; however, current CFTR modulator therapies are only available for a minority of…”
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Practical measurement of affordability: an application to medicines by NIËNS, L. M, VAN DE POEL, E, CAMERON, A, EWEN, M, LAING, R, BROUWER, Wbf

“…To develop two practical methods for measuring the affordability of medicines in developing countries. The proposed methods--catastrophic and impoverishment…”
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Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids by de Poel, E., Spelier, S., Suen, S.W.F., Kruisselbrink, E., Graeber, S.Y., Mall, M.A., Weersink, E.J.M., van der Eerden, M.M., Koppelman, G.H., van der Ent, C.K., Beekman, J.M.

“…•Pharmacological repair of CFTR function beyond F508del/F508del-VX809/VX770 in intestinal organoids with homozygous PTC mutations.•The read-through agent…”
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Clonal Evolution of Autoreactive Germinal Centers by Degn, Søren E., van der Poel, Cees E., Firl, Daniel J., Ayoglu, Burcu, Al Qureshah, Fahd A., Bajic, Goran, Mesin, Luka, Reynaud, Claude-Agnès, Weill, Jean-Claude, Utz, Paul J., Victora, Gabriel D., Carroll, Michael C.

“…Germinal centers (GCs) are the primary sites of clonal B cell expansion and affinity maturation, directing the production of high-affinity antibodies. This…”
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FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes by de Poel, E., Spelier, S., Hagemeijer, M.C., van Mourik, P., Suen, S.W.F., Vonk, A.M., Brunsveld, J.E., Ithakisiou, G.N., Kruisselbrink, E., Oppelaar, H., Berkers, G., de Winter de Groot, K.M., Heida-Michel, S., Jans, S.R., van Panhuis, H., Bakker, M., van der Meer, R., Roukema, J., Dompeling, E., Weersink, E.J.M., Koppelman, G.H., Blaazer, A.R., Muijlwijk-Koezen, J.E., van der Ent, C.K., Beekman, J.M.

“…•We implemented a high-throughput 384-wells version of the functional FIS assay to screen a large number of PDIOs for compounds that enhance CFTR function.•We…”
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Antigen presentation by B cells enables epitope spreading across an MHC barrier by Fahlquist-Hagert, Cecilia, Wittenborn, Thomas R., Terczyńska-Dyla, Ewa, Kastberg, Kristian Savstrup, Yang, Emily, Rallistan, Alysa Nicole, Markett, Quinton Raymond, Winther, Gudrun, Fonager, Sofie, Voss, Lasse F., Pedersen, Mathias K., van Campen, Nina, Ferapontov, Alexey, Jensen, Lisbeth, Huang, Jinrong, Nieland, John D., van der Poel, Cees E., Palmfeldt, Johan, Carroll, Michael C., Utz, Paul J., Luo, Yonglun, Lin, Lin, Degn, Søren E.

“…Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single…”
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The relation between cardiac 123I-mIBG scintigraphy and functional response 1 year after CRT implantation by Verschure, D O, Poel, E, De Vincentis, G, Frantellizzi, V, Nakajima, K, Gheysens, O, de Groot, J R, Verberne, H J

“…Abstract Aims  Cardiac resynchronization therapy (CRT) is a disease-modifying therapy in patients with chronic heart failure (CHF). Current guidelines ascribe…”
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Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB by van der Poel, Cees E., Bajic, Goran, Macaulay, Charles W., van den Broek, Theo, Ellson, Christian D., Bouma, Gerben, Victora, Gabriel D., Degn, Søren E., Carroll, Michael C.

“…Follicular dendritic cells (FDCs), a rare and enigmatic stromal cell type in the B cell follicles of secondary lymphoid organs, store and present antigen to B…”
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Complement C4A Regulates Autoreactive B Cells in Murine Lupus by Simoni, Léa, Presumey, Jessy, van der Poel, Cees E., Castrillon, Carlos, Chang, Sarah E., Utz, Paul J., Carroll, Michael C.

“…Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE,…”
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The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden by BOROSS, Peter, MARCO JANSEN, J. H, LEUSEN, Jeanette H. W, DE HAIJ, Simone, BEURSKENS, Frank J, VAN DER POEL, Cees E, BEVAART, Lisette, NEDEREND, Maaike, GOLAY, Josée, VAN DE WINKEL, Jan G. J, PARREN, Paul W. H. I

“…CD20 monoclonal antibodies are widely used in clinical practice. Antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity and direct cell…”
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Microsatellite diversity of the Nordic type of goats in relation to breed conservation: how relevant is pure ancestry? by Lenstra, J.A., Tigchelaar, J., Biebach, I., Hallsson, J.H., Kantanen, J., Nielsen, V.H., Pompanon, F., Naderi, S., Rezaei, H.‐R., Sæther, N., Ertugrul, O., Grossen, C., Camenisch, G., Vos‐Loohuis, M., Straten, M., Poel, E.A., Windig, J., Oldenbroek, K., Abo‐Shehada, Mahamoud, Marsan, Paolo Ajmone, Tarrayrah, Jamil Al, Angiolillo, Antonella, Baret, Philip, Baumung, Roswitha, Beja‐Pereira, Albano, Bertaglia, Marco, Bordonaro, Salvatore, Brandt, Horst, Bruford, Mike, Caloz, Régis, Canali, Gabriele, Canon, Javier, Cappuccio, Irene, Carta, Antonello, Cicogna, Mario, Crepaldi, Paola, Dalamitra, Stella, Dobi, Petrit, Dunner, Susana, D'Urso, Giuseppe, El Barody, M. A. A., England, Phillip, Erhardt, Georg, Ertuğrul, Okan, Glowatzki, Marie‐Louise, Ibeagha‐Awemu, Eveline, Strzelec, Ewa, Fadlaoui, Aziz, Fornarelli, Francesca, Garcia, David, Georgoudis, Andreas, Giovenzana, Stefano, Gutscher, Katja, Hewitt, Godfrey, Hoda, Anila, Istvan, Anton, Jones, Sam, Joost, Stéphane, Juma, Gabriela, Karetsou, Katerina, Kliambas, Georgios, Koban, Evren, Krugmann, Daniela, Kutita, Olga, Lazlo, Fesus, Ligda, Christina, Lipsky, Shirin, Luikart, Gordon, Lühken, Gesine, Marilli, Marta, Marletta, Donata, Milanesi, Elisabetta, Negrini, Riccardo, Nijman, Isaäc J., Niznikowski, Roman, Obexer‐Ruff, Gabriela, Papachristoforou, Christos, Pariset, Lorraine, Peter, Marco Pellecchia, Christina, Perez, Trinidad, Pietrolà, Emilio, Pilla, Fabio, Popielarczyk, Dominik, Prinzenberg, Maria‐Eva, Roosen, Jutta, Scarpa, Riccardo, Sechi, Tiziana, Taberlet, Pierre, Taylor, Martin, Togan, Inci, Trommetter, Michel, Valentini, Alessio, Van Cann, Lisette M., Vlaic, Augustin, Wiskin, Louise, Zundel, Stéphanie

“…Summary In the last decades, several endangered breeds of livestock species have been re‐established effectively. However, the successful revival of the Dutch…”
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Antigen Presentation to B Cells by Heesters, Balthasar A, van der Poel, Cees E, Das, Abhishek, Carroll, Michael C

“…Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also…”
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The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease by Wang, Ninghai, Yigit, Burcu, van der Poel, Cees E, Cuenca, Marta, Carroll, Michael C, Herzog, Roland W, Engel, Pablo, Terhorst, Cox

“…Absence of the mouse cell surface receptor SLAMF3 in SLAMF3-/- mice suggested that this receptor negatively regulates B cell homeostasis by modulating…”
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WS18.2 The rainbow project: personalised medicine for CF-patients with rare mutations by van Mourik, P, Berkers, G, Vonk, A.M, de Poel, E, Hagemeijer, M.C, Majoor, C.J, Heijerman, H.G.M, Koppelman, G.H, Roukema, J, Bannier, M.A.G.E, Janssens, H.M, Beekman, J.M, van der Ent, C.K

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Microglia-dependent synapse loss in type I interferon-mediated lupus by Bialas, Allison R., Presumey, Jessy, Das, Abhishek, van der Poel, Cees E., Lapchak, Peter H., Mesin, Luka, Victora, Gabriel, Tsokos, George C., Mawrin, Christian, Herbst, Ronald, Carroll, Michael C.

“…Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further…”
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