Search Results - "Poehner, Ina"

Structure and dynamics of pteridine reductase 1: the key phenomena relevant to enzyme function and drug design by Panecka-Hofman, Joanna, Poehner, Ina

“…Pteridine reductase 1 (PTR1) is a folate and pterin pathway enzyme unique for pathogenic trypanosomatids. As a validated drug target, PTR1 has been the focus…”
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MCMapA Computational Tool for Mapping Energy Landscapes of Transient Protein–Protein Interactions by Foerster, Johannes M, Poehner, Ina, Ullmann, G. Matthias

“…MCMap is a tool particularly well-suited for analyzing energy landscapes of transient macromolecular complexes. The program applies a Monte Carlo strategy,…”
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Global profiling of SRP interaction with nascent polypeptides by Schibich, Daniela, Gloge, Felix, Pöhner, Ina, Björkholm, Patrik, Wade, Rebecca C., von Heijne, Gunnar, Bukau, Bernd, Kramer, Günter

“…Here, the selection of substrates by the protein–RNA complex known as the signal recognition particle (SRP) is investigated in the bacterium Escherichia coli ,…”
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Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1 by Pöhner, Ina, Quotadamo, Antonio, Panecka-Hofman, Joanna, Luciani, Rosaria, Santucci, Matteo, Linciano, Pasquale, Landi, Giacomo, Di Pisa, Flavio, Dello Iacono, Lucia, Pozzi, Cecilia, Mangani, Stefano, Gul, Sheraz, Witt, Gesa, Ellinger, Bernhard, Kuzikov, Maria, Santarem, Nuno, Cordeiro-da-Silva, Anabela, Costi, Maria P., Venturelli, Alberto, Wade, Rebecca C.

“…The optimization of compounds with multiple targets is a difficult multidimensional problem in the drug discovery cycle. Here, we present a systematic,…”
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The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing by Begolo, Daniela, Vincent, Isabel M, Giordani, Federica, Pöhner, Ina, Witty, Michael J, Rowan, Timothy G, Bengaly, Zakaria, Gillingwater, Kirsten, Freund, Yvonne, Wade, Rebecca C, Barrett, Michael P, Clayton, Christine

“…Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing…”
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Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors by Panecka-Hofman, Joanna, Pöhner, Ina, Spyrakis, Francesca, Zeppelin, Talia, Di Pisa, Flavio, Dello Iacono, Lucia, Bonucci, Alessio, Quotadamo, Antonio, Venturelli, Alberto, Mangani, Stefano, Costi, Maria Paola, Wade, Rebecca C.

“…[Display omitted] Multi-target approaches are necessary to properly analyze or modify the function of a biochemical pathway or a protein family. An example of…”
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Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity by Di Pisa, Flavio, Landi, Giacomo, Dello Iacono, Lucia, Pozzi, Cecilia, Borsari, Chiara, Ferrari, Stefania, Santucci, Matteo, Santarem, Nuno, Cordeiro-da-Silva, Anabela, Moraes, Carolina B, Alcantara, Laura M, Fontana, Vanessa, Freitas-Junior, Lucio H, Gul, Sheraz, Kuzikov, Maria, Behrens, Birte, Pöhner, Ina, Wade, Rebecca C, Costi, Maria Paola, Mangani, Stefano

“…Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus our attention on the…”
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MatchTope: A tool to predict the cross reactivity of peptides complexed with Major Histocompatibility Complex I by Mendes, Marcus Fabiano de Almeida, de Souza Bragatte, Marcelo, Vianna, Priscila, de Freitas, Martiela Vaz, Pöhner, Ina, Richter, Stefan, Wade, Rebecca C, Salzano, Francisco Mauro, Vieira, Gustavo Fioravanti

“…The therapeutic targeting of the immune system, for example in vaccinology and cancer treatment, is a challenging task and the subject of active research…”
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Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs by Borsari, Chiara, Luciani, Rosaria, Pozzi, Cecilia, Poehner, Ina, Henrich, Stefan, Trande, Matteo, Cordeiro-da-Silva, Anabela, Santarem, Nuno, Baptista, Catarina, Tait, Annalisa, Di Pisa, Flavio, Dello Iacono, Lucia, Landi, Giacomo, Gul, Sheraz, Wolf, Markus, Kuzikov, Maria, Ellinger, Bernhard, Reinshagen, Jeanette, Witt, Gesa, Gribbon, Philip, Kohler, Manfred, Keminer, Oliver, Behrens, Birte, Costantino, Luca, Tejera Nevado, Paloma, Bifeld, Eugenia, Eick, Julia, Clos, Joachim, Torrado, Juan, Jiménez-Antón, María D, Corral, María J, Alunda, José Ma, Pellati, Federica, Wade, Rebecca C, Ferrari, Stefania, Mangani, Stefano, Costi, Maria Paola

“…Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a library of natural products, we combined target-based screening on…”
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Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform by Moraes, Carolina B, Witt, Gesa, Kuzikov, Maria, Ellinger, Bernhard, Calogeropoulou, Theodora, Prousis, Kyriakos C, Mangani, Stefano, Di Pisa, Flavio, Landi, Giacomo, Iacono, Lucia Dello, Pozzi, Cecilia, Freitas-Junior, Lucio H, Dos Santos Pascoalino, Bruno, Bertolacini, Claudia P, Behrens, Birte, Keminer, Oliver, Leu, Jennifer, Wolf, Markus, Reinshagen, Jeanette, Cordeiro-da-Silva, Anabela, Santarem, Nuno, Venturelli, Alberto, Wrigley, Stephen, Karunakaran, Deepa, Kebede, Bethlehem, Pöhner, Ina, Müller, Wolfgang, Panecka-Hofman, Joanna, Wade, Rebecca C, Fenske, Martina, Clos, Joachim, Alunda, José María, Corral, María Jesús, Uliassi, Elisa, Bolognesi, Maria Laura, Linciano, Pasquale, Quotadamo, Antonio, Ferrari, Stefania, Santucci, Matteo, Borsari, Chiara, Costi, Maria Paola, Gul, Sheraz

“…According to the World Health Organization, more than 1 billion people are at risk of or are affected by neglected tropical diseases. Examples of such diseases…”
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Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Linciano, Pasquale, Dawson, Alice, Pöhner, Ina, Costa, David M, Sá, Monica S, Cordeiro-da-Silva, Anabela, Luciani, Rosaria, Gul, Sheraz, Witt, Gesa, Ellinger, Bernhard, Kuzikov, Maria, Gribbon, Philip, Reinshagen, Jeanette, Wolf, Markus, Behrens, Birte, Hannaert, Véronique, Michels, Paul A. M, Nerini, Erika, Pozzi, Cecilia, di Pisa, Flavio, Landi, Giacomo, Santarem, Nuno, Ferrari, Stefania, Saxena, Puneet, Lazzari, Sandra, Cannazza, Giuseppe, Freitas-Junior, Lucio H, Moraes, Carolina B, Pascoalino, Bruno S, Alcântara, Laura M, Bertolacini, Claudia P, Fontana, Vanessa, Wittig, Ulrike, Müller, Wolfgang, Wade, Rebecca C, Hunter, William N, Mangani, Stefano, Costantino, Luca, Costi, Maria P

“…Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis. We investigated the potential of a previously identified class of…”
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