Search Results - "Podoll, Jessica D"

Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics by Podoll, Jessica D., Liu, Yongxiang, Chang, Le, Walls, Shane, Wang, Wei, Wang, Xiang

“…The continuous emergence of resistant bacteria has become a major worldwide health threat. The current development of new antibacterials has lagged far behind…”
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A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load by Reens, Abigail L, Crooks, Amy L, Su, Chih-Chia, Nagy, Toni A, Reens, David L, Podoll, Jessica D, Edwards, Madeline E, Yu, Edward W, Detweiler, Corrella S

“…Bacterial efflux pumps transport small molecules from the cytoplasm or periplasm outside the cell. Efflux pump activity is typically increased in multi-drug…”
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Discovery and initial structure-activity relationships of N-benzyl tricyclic indolines as antibacterials for methicillin-resistant Staphylococcus aureus by Michael Barbour, P, Podoll, Jessica D, Marholz, Laura J, Wang, Xiang

“…Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent drug resistant bacteria. In 2012, over 11,000 fatalities in the United States…”
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A small-molecule membrane fluidizer re-sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics by Podoll, Jessica D, Rosen, Emma, Wang, Wei, Gao, Yuefeng, Zhang, Jing, Wang, Xiang

“…Novel antibacterial agents and strategies are urgently needed to fight against the ongoing global antibiotic resistance problem. While natural products remain…”
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Increase in cerebral blood flow indicated by increased cerebral arterial area and pixel intensity on brain magnetic resonance angiogram following correction of cervical lordosis by Katz, Evan A, Katz, Seana B, Fedorchuk, Curtis A, Lightstone, Douglas F, Banach, Chris J, Podoll, Jessica D

“…Loss of cervical lordosis is associated with decreased vertebral artery hemodynamics. The aim of this study is to evaluate cerebral blood flow changes on brain…”
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Tetracyclic indolines as a novel class of β-lactam-selective resistance-modifying agent for MRSA by Zhu, Yugen, Cleaver, Lakota, Wang, Wei, Podoll, Jessica D., Walls, Shane, Jolly, Austin, Wang, Xiang

“…Antibiotic-resistant bacterial infections have seen a marked increase in recent years, while antibiotic discovery has waned. Resistance-modifying agents (RMA)…”
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Quantitative Analysis of Histone Demethylase Probes Using Fluorescence Polarization by Xu, Wenqing, Podoll, Jessica D, Dong, Xuan, Tumber, Anthony, Oppermann, Udo, Wang, Xiang

“…We previously reported methylstat as a selective inhibitor of jumonji C domain-containing histone demethylases (JHDMs). Herein, we describe the synthesis of a…”
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Structure–Activity Relationship Studies of the Tricyclic Indoline Resistance-Modifying Agent by Chang, Le, Podoll, Jessica D, Wang, Wei, Walls, Shane, O’Rourke, Courtney P, Wang, Xiang

“…Previously we discovered a tricyclic indoline, N-[2-(6-bromo-4-methylidene-2,3,4,4a,9,9a-hexahydro-1H-carbazol-4a-yl)­ethyl]-4-chlorobenzene-1-sulfonamide (1,…”
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Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia by di Villa Bianca, Roberta d'Emmanuele, Mitidieri, Emma, Di Minno, Matteo N. D., Kirkby, Nicholas S., Warner, Timothy D., Di Minno, Giovanni, Cirino, Giuseppe, Sorrentino, Raffaella

“…Homocysteine is metabolized to methionine by the action of 5,10 methylenetetrahydrofolate reductase (MTHFR). Alternatively, by the transulfuration pathway,…”
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Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to [Beta]-lactam antibiotics by Podoll, Jessica D, Liu, Yongxiang, Chang, Le, Walls, Shane, Wang, Wei, Wang, Xiang

“…The continuous emergence of resistant bacteria has become a major worldwide health threat. The current development of new antibacterials has lagged far behind…”
Get full text