Search Results - "Podoll, Jessica"

A small-molecule membrane fluidizer re-sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics by Podoll, Jessica D, Rosen, Emma, Wang, Wei, Gao, Yuefeng, Zhang, Jing, Wang, Xiang

“…Novel antibacterial agents and strategies are urgently needed to fight against the ongoing global antibiotic resistance problem. While natural products remain…”
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Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics by Podoll, Jessica D., Liu, Yongxiang, Chang, Le, Walls, Shane, Wang, Wei, Wang, Xiang

“…The continuous emergence of resistant bacteria has become a major worldwide health threat. The current development of new antibacterials has lagged far behind…”
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A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load by Reens, Abigail L, Crooks, Amy L, Su, Chih-Chia, Nagy, Toni A, Reens, David L, Podoll, Jessica D, Edwards, Madeline E, Yu, Edward W, Detweiler, Corrella S

“…Bacterial efflux pumps transport small molecules from the cytoplasm or periplasm outside the cell. Efflux pump activity is typically increased in multi-drug…”
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Tetracyclic indolines as a novel class of β-lactam-selective resistance-modifying agent for MRSA by Zhu, Yugen, Cleaver, Lakota, Wang, Wei, Podoll, Jessica D., Walls, Shane, Jolly, Austin, Wang, Xiang

“…Antibiotic-resistant bacterial infections have seen a marked increase in recent years, while antibiotic discovery has waned. Resistance-modifying agents (RMA)…”
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A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases by Luo, Xuelai, Liu, Yongxiang, Kubicek, Stefan, Myllyharju, Johanna, Tumber, Anthony, Ng, Stanley, Che, Ka Hing, Podoll, Jessica, Heightman, Tom D, Oppermann, Udo, Schreiber, Stuart L, Wang, Xiang

“…Histone methylations are important chromatin marks that regulate gene expression, genomic stability, DNA repair, and genomic imprinting. Histone demethylases…”
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Discovery and initial structure-activity relationships of N-benzyl tricyclic indolines as antibacterials for methicillin-resistant Staphylococcus aureus by Michael Barbour, P, Podoll, Jessica D, Marholz, Laura J, Wang, Xiang

“…Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent drug resistant bacteria. In 2012, over 11,000 fatalities in the United States…”
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Quantitative Analysis of Histone Demethylase Probes Using Fluorescence Polarization by Xu, Wenqing, Podoll, Jessica D, Dong, Xuan, Tumber, Anthony, Oppermann, Udo, Wang, Xiang

“…We previously reported methylstat as a selective inhibitor of jumonji C domain-containing histone demethylases (JHDMs). Herein, we describe the synthesis of a…”
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Structure–Activity Relationship Studies of the Tricyclic Indoline Resistance-Modifying Agent by Chang, Le, Podoll, Jessica D, Wang, Wei, Walls, Shane, O’Rourke, Courtney P, Wang, Xiang

“…Previously we discovered a tricyclic indoline, N-[2-(6-bromo-4-methylidene-2,3,4,4a,9,9a-hexahydro-1H-carbazol-4a-yl)­ethyl]-4-chlorobenzene-1-sulfonamide (1,…”
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A Cell-Free Screen for Bacterial Membrane Disruptors Identifies Mefloquine as a Novel Antibiotic Adjuvant by Podoll, Jessica, Olson, Justin, Wang, Wei, Wang, Xiang

“…Antibacterial discovery efforts have lagged far behind the need for new antibiotics. An approach that has gained popularity recently is targeting bacterial…”
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Increase in cerebral blood flow indicated by increased cerebral arterial area and pixel intensity on brain magnetic resonance angiogram following correction of cervical lordosis by Katz, Evan A, Katz, Seana B, Fedorchuk, Curtis A, Lightstone, Douglas F, Banach, Chris J, Podoll, Jessica D

“…Loss of cervical lordosis is associated with decreased vertebral artery hemodynamics. The aim of this study is to evaluate cerebral blood flow changes on brain…”
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Abstract P141: Preclinical characterization of LOX-24350, a highly potent and isoform-selective FGFR3 inhibitor by Ballard, Joshua A., Kercher, Timothy, Abraham, David, Brecht, Ryan, Brooks, Nathan A., Buckles, Thomas, Bume, Desta, Busha, David, Cedervall, Ernst Peder, Condroski, Kevin, Ebata, Kevin, Gharbi, Severine Isabelle, Hazlitt, Robert, Morales, Tony, Patel, Nisha, Podoll, Jessica, Urkalan, Kaveri, Villalain, Sandra Gomez, Walls, Shane, Watson, Faith, Yang, Peiyi, Brandhuber, Barbara J., Andrews, Steven W.

“…Alterations in the fibroblast growth factor receptors (FGFRs) have been identified as oncogenic drivers in many human cancers. Specifically, activating FGFR3…”
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Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia by di Villa Bianca, Roberta d'Emmanuele, Mitidieri, Emma, Di Minno, Matteo N. D., Kirkby, Nicholas S., Warner, Timothy D., Di Minno, Giovanni, Cirino, Giuseppe, Sorrentino, Raffaella

“…Homocysteine is metabolized to methionine by the action of 5,10 methylenetetrahydrofolate reductase (MTHFR). Alternatively, by the transulfuration pathway,…”
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Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to [Beta]-lactam antibiotics by Podoll, Jessica D, Liu, Yongxiang, Chang, Le, Walls, Shane, Wang, Wei, Wang, Xiang

“…The continuous emergence of resistant bacteria has become a major worldwide health threat. The current development of new antibacterials has lagged far behind…”
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Discovery and biochemical evaluation of chemical probes for the study of jumonji-C domain containing histone demethylases and antibiotic resistance machinery in MRSA by Podoll, Jessica Danielle

“…Part I: Histone demethylases (HDMs) are vital epigenetic regulators that have been implicated in multiple disease states including cancers. Demethylation…”
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Discovery and biochemical evaluation of chemical probes for the study of jumonji-C domain containing histone demethylases and antibiotic resistance machinery in MRSA by Podoll, Jessica Danielle

“…Part I: Histone demethylases (HDMs) are vital epigenetic regulators that have been implicated in multiple disease states including cancers. Demethylation…”
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