Search Results - "Podkowa, Adrian"

Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity by Podkowa, Adrian, Kryczyk-Poprawa, Agata, Opoka, Włodzimierz, Muszyńska, Bożena

“…There are about 3000 species of mushrooms, which have a high amount of substances that are beneficial to human health, such as antioxidants. It is well known…”
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Development of an in-vivo active reversible butyrylcholinesterase inhibitor by Košak, Urban, Brus, Boris, Knez, Damijan, Šink, Roman, Žakelj, Simon, Trontelj, Jurij, Pišlar, Anja, Šlenc, Jasna, Gobec, Martina, Živin, Marko, Tratnjek, Larisa, Perše, Martina, Sałat, Kinga, Podkowa, Adrian, Filipek, Barbara, Nachon, Florian, Brazzolotto, Xavier, Więckowska, Anna, Malawska, Barbara, Stojan, Jure, Raščan, Irena Mlinarič, Kos, Janko, Coquelle, Nicolas, Colletier, Jacques-Philippe, Gobec, Stanislav

“…Alzheimer’s disease (AD) is characterized by severe basal forebrain cholinergic deficit, which results in progressive and chronic deterioration of memory and…”
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Antidepressant-like effects of scopolamine in mice are enhanced by the group II mGlu receptor antagonist LY341495 by Podkowa, Karolina, Podkowa, Adrian, Sałat, Kinga, Lenda, Tomasz, Pilc, Andrzej, Pałucha-Poniewiera, Agnieszka

“…Clinical studies have shown that the muscarinic receptor antagonist scopolamine induces a potent and rapid antidepressant effect relative to conventional…”
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Yerba Mate as a Source of Elements and Bioactive Compounds with Antioxidant Activity by Rząsa-Duran, Elżbieta, Kryczyk-Poprawa, Agata, Drabicki, Dawid, Podkowa, Adrian, Sułkowska-Ziaja, Katarzyna, Szewczyk, Agnieszka, Kała, Katarzyna, Opoka, Włodzimierz, Zięba, Piotr, Fidurski, Maciej, Muszyńska, Bożena

“…(yerba mate) is a plant species of the holly genus Ilex native to South America from the family Aquifoliaceae and is used for the production of yerba mate…”
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The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity by Košak, Urban, Brus, Boris, Knez, Damijan, Žakelj, Simon, Trontelj, Jurij, Pišlar, Anja, Šink, Roman, Jukič, Marko, Živin, Marko, Podkowa, Adrian, Nachon, Florian, Brazzolotto, Xavier, Stojan, Jure, Kos, Janko, Coquelle, Nicolas, Sałat, Kinga, Colletier, Jacques-Philippe, Gobec, Stanislav

“…The enzymatic activity of butyrylcholinesterase (BChE) in the brain increases with the progression of Alzheimer’s disease, thus classifying BChE as a promising…”
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Phencyclidine and Scopolamine for Modeling Amnesia in Rodents: Direct Comparison with the Use of Barnes Maze Test and Contextual Fear Conditioning Test in Mice by Malikowska-Racia, Natalia, Podkowa, Adrian, Sałat, Kinga

“…Nowadays cognitive impairments are a growing unresolved medical issue which may accompany many diseases and therapies, furthermore, numerous researchers…”
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The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect by Pytka, Karolina, Podkowa, Karolina, Rapacz, Anna, Podkowa, Adrian, Żmudzka, Elżbieta, Olczyk, Adrian, Sapa, Jacek, Filipek, Barbara

“…Depression is a serious global illness, becoming more and more common in developed countries. Because of specific symptoms it is considered as a leading cause…”
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Impact of dams' diet on the levels of magnesium and zinc in the incisors of offspring rats by Podkowa, Adrian, Gawliński, Dawid, Gawlińska, Kinga, Muszyńska, Bożena, Opoka, Włodzimierz

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Anticonvulsant active inhibitor of GABA transporter subtype 1, tiagabine, with activity in mouse models of anxiety, pain and depression by Sałat, Kinga, Podkowa, Adrian, Kowalczyk, Paula, Kulig, Katarzyna, Dziubina, Anna, Filipek, Barbara, Librowski, Tadeusz

“…Tiagabine, a selective inhibitor of GABA transporter subtype 1 is used as an add-on therapy of partial seizures in humans but its mechanism of action suggests…”
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The potential antidepressant action and adverse effects profile of scopolamine co-administered with the mGlu7 receptor allosteric agonist AMN082 in mice by Podkowa, Karolina, Pilc, Andrzej, Podkowa, Adrian, Sałat, Kinga, Marciniak, Marcin, Pałucha-Poniewiera, Agnieszka

“…Scopolamine, a muscarinic cholinergic receptor antagonist, exerts fast and prolonged antidepressant effects in the clinic. In contrast, the current treatments…”
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Comparison of pro-amnesic efficacy of scopolamine, biperiden, and phencyclidine by using passive avoidance task in CD-1 mice by Malikowska, Natalia, Sałat, Kinga, Podkowa, Adrian

“…Memory disorders accompany numerous diseases and therapies, and this is becoming a growing medical issue worldwide. Currently, various animal models of memory…”
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Potential role of selected antiepileptics used in neuropathic pain as human GABA transporter isoform 1 (GAT1) inhibitors—Molecular docking and pharmacodynamic studies by Fijałkowski, Łukasz, Sałat, Kinga, Podkowa, Adrian, Zaręba, Paula, Nowaczyk, Alicja

“…The chemical interaction of nine antiepileptic drugs (tiagabine, gabapentin, pregabalin, lamotrigine, zonisamide, valproic acid, valpromide, vigabatrin,…”
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Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures by Łączkowski, Krzysztof Z, Sałat, Kinga, Misiura, Konrad, Podkowa, Adrian, Malikowska, Natalia

“…Synthesis, characterization and investigation of in vivo anticonvulsant activities of 13 novel cyclopentanecarbaldehyde-based 2,4-disubstituted 1,3-thiazoles…”
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Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties by Sałat, Kinga, Podkowa, Adrian, Malikowska, Natalia, Kern, Felix, Pabel, Jörg, Wojcieszak, Ewelina, Kulig, Katarzyna, Wanner, Klaus T., Strach, Beata, Wyska, Elżbieta

“…Since GABAergic dysfunction underlies a variety of neurological and psychiatric disorders, numerous strategies leading to the augmentation of GABAergic…”
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Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity by Zaręba, Paula, Sałat, Kinga, Höfner, Georg C., Łątka, Kamil, Bajda, Marek, Latacz, Gniewomir, Kotniewicz, Krzysztof, Rapacz, Anna, Podkowa, Adrian, Maj, Maciej, Jóźwiak, Krzysztof, Filipek, Barbara, Wanner, Klaus T., Malawska, Barbara, Kulig, Katarzyna

“…γ-Aminobutyric acid (GABA) neurotransmission has a significant impact on the proper functioning of the central nervous system. Numerous studies have indicated…”
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Studies on the Activity of Selected Highly Lipophilic Compounds toward hGAT1 Inhibition. Part II by Nowaczyk, Alicja, Fijałkowski, Łukasz, Kowalska, Magdalena, Podkowa, Adrian, Sałat, Kinga

“…In this paper, we describe the latest results involving molecular modeling and pharmacodynamic studies of the selected highly lipophilic compounds acting by…”
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The effect of GABA transporter 1 (GAT1) inhibitor, tiagabine, on scopolamine-induced memory impairments in mice by Sałat, Kinga, Podkowa, Adrian, Mogilski, Szczepan, Zaręba, Paula, Kulig, Katarzyna, Sałat, Robert, Malikowska, Natalia, Filipek, Barbara

“…GABAergic neurotransmission is involved in long-term potentiation, a neurophysiological basis for learning and memory. On the other hand, GABA-enhancing drugs…”
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Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice by Zaręba, Paula, Gryzło, Beata, Malawska, Katarzyna, Sałat, Kinga, Höfner, Georg C., Nowaczyk, Alicja, Fijałkowski, Łukasz, Rapacz, Anna, Podkowa, Adrian, Furgała, Anna, Żmudzki, Paweł, Wanner, Klaus T., Malawska, Barbara, Kulig, Katarzyna

“…γ-Aminobutyric acid (GABA) uptake transporters are membrane transport proteins that are involved in the pathophysiology of a number of neurological disorders…”
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Effect of pregabalin on contextual memory deficits and inflammatory state-related protein expression in streptozotocin-induced diabetic mice by Sałat, Kinga, Gdula-Argasińska, Joanna, Malikowska, Natalia, Podkowa, Adrian, Lipkowska, Anna, Librowski, Tadeusz

“…Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to defects in insulin secretion or its action. Complications from long-term…”
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Abstract 1281: Development and characterization of small molecule HPK1 inhibitors by Kujawa, Maciej, Zimoląg, Eliza, Gałęzowski, Michał, Guzik, Paweł, Dudek, Agata, Gondela, Andrzej, Nowogródzki, Marcin, Girardi, Marianna, Krolenko, Kostiantyn, Bugaj, Marta, Sudoł, Sylwia, Gibas, Agnieszka, Szeremeta-Spisak, Joanna, Bobowska, Aneta, Zastawna, Magdalena, Wyrębek, Przemysław, Boutard, Nicolas, Więckowska, Aleksandra, Jasnosz, Wojciech, Schonemann, Wojciech, Zuchowicz, Karol, Synak, David, Kulesza, Urszula, Leventes, Oleksandr, Świrski, Mateusz, Sasmal, Sujit, Gluza, Karolina, Kret, Patryk, Ogórek, Mateusz, Michalik, Kinga, Banaszak, Katarzyna, Podkowa, Adrian, Wnuk-Lipińska, Katarzyna, Dobrzańska, Monika, Littlewood, Peter, Brzózka, Krzysztof, Bartosik, Anna, Chmielewski, Stefan

“…Abstract Background: Hematopoietic progenitor kinase 1 (HPK1, MAP4K1) is a member of the serine/threonine MAP4K family predominantly expressed in hematopoietic…”
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