Search Results - "Podell, Brendan K"

Host-directed therapy targeting the Mycobacterium tuberculosis granuloma: a review by Kiran, Dilara, Podell, Brendan K., Chambers, Mark, Basaraba, Randall J.

“…Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major cause of morbidity and mortality worldwide. Slow progress has…”
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High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types by Blanc, Landry, Daudelin, Isaac B, Podell, Brendan K, Chen, Pei-Yu, Zimmerman, Matthew, Martinot, Amanda J, Savic, Rada M, Prideaux, Brendan, Dartois, Véronique

“…Understanding the distribution patterns of antibiotics at the site of infection is paramount to selecting adequate drug regimens and developing new…”
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Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses by Walter, Nicholas D, Ernest, Jackie P, Dide-Agossou, Christian, Bauman, Allison A, Ramey, Michelle E, Rossmassler, Karen, Massoudi, Lisa M, Pauly, Samantha, Al Mubarak, Reem, Voskuil, Martin I, Kaya, Firat, Sarathy, Jansy P, Zimmerman, Matthew D, Dartois, Véronique, Podell, Brendan K, Savic, Radojka M, Robertson, Gregory T

“…Tuberculosis lung lesions are complex and harbor heterogeneous microenvironments that influence antibiotic effectiveness. Major strides have been made recently…”
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ELISA-R: an R-based method for robust ELISA data analysis by Dutt, Taru S, Spencer, John S, Karger, Burton R, Fox, Amy, Obregon-Henao, Andres, Podell, Brendan K, Anderson, G Brooke, Henao-Tamayo, Marcela

“…Enzyme-linked immunosorbent assay (ELISA) is a technique to detect the presence of an antigen or antibody in a sample. ELISA is a simple and cost-effective…”
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Standardized guinea pig model for Q fever vaccine reactogenicity by Baeten, Laurie A, Podell, Brendan K, Sluder, Ann E, Garritsen, Anja, Bowen, Richard A, Poznansky, Mark C

“…Historically, vaccination with Coxiella burnetii whole cell vaccines has induced hypersensitivity reactions in humans and animals that have had prior exposure…”
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Heterogeneity in immune cell composition is associated with Mycobacterium tuberculosis replication at the granuloma level by Cooper, Sarah K, Ackart, David Forrest, Lanni, Faye, Henao-Tamayo, Marcela, Anderson, G Brooke, Podell, Brendan K

“…The control of bacterial growth is key to the prevention and treatment of tuberculosis (TB). Granulomas represent independent foci of the host immune response…”
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Gliosis, misfolded protein aggregation, and neuronal loss in a guinea pig model of pulmonary tuberculosis by Latham, Amanda S, Geer, Charlize E, Ackart, David F, Anderson, Isla K, Vittoria, Kaley M, Podell, Brendan K, Basaraba, Randall J, Moreno, Julie A

“…Tuberculosis, caused by infection, is an ongoing epidemic with an estimated ten million active cases of the disease worldwide. Pulmonary tuberculosis is…”
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Subunit vaccine protects against a clinical isolate of Mycobacterium avium in wild type and immunocompromised mouse models by Larsen, Sasha E., Reese, Valerie A., Pecor, Tiffany, Berube, Bryan J., Cooper, Sarah K., Brewer, Guy, Ordway, Diane, Henao-Tamayo, Marcela, Podell, Brendan K., Baldwin, Susan L., Coler, Rhea N.

“…The nontuberculous mycobacteria (NTM) Mycobacterium avium is a clinically significant pathogen that can cause a wide range of maladies, including…”
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Protective interplay: Mycobacterium tuberculosis diminishes SARS-CoV-2 severity through innate immune priming by Williams, Brittany D, Ferede, Debora, Abdelaal, Hazem F M, Berube, Bryan J, Podell, Brendan K, Larsen, Sasha E, Baldwin, Susan L, Coler, Rhea N

“…At the beginning of the COVID-19 pandemic those with underlying chronic lung conditions, including tuberculosis (TB), were hypothesized to be at higher risk of…”
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Therapeutic efficacy against Mycobacterium tuberculosis using ID93 and liposomal adjuvant formulations by Baldwin, Susan L, Reese, Valerie A, Larsen, Sasha E, Pecor, Tiffany, Brown, Bryan P, Granger, Brian, Podell, Brendan K, Fox, Christopher B, Reed, Steven G, Coler, Rhea N

“…( ) has led to approximately 1.3 million deaths globally in 2020 according to the World Health Organization (WHO). More effective treatments are therefore…”
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Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks by Asay, Bryce C., Edwards, Blake Blue, Andrews, Jenna, Ramey, Michelle E., Richard, Jameson D., Podell, Brendan K., Gutiérrez, Juan F. Muñoz, Frank, Chad B., Magunda, Forgivemore, Robertson, Gregory T., Lyons, Michael, Ben-Hur, Asa, Lenaerts, Anne J.

“…Efforts to develop effective and safe drugs for treatment of tuberculosis require preclinical evaluation in animal models. Alongside efficacy testing of novel…”
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A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment by Podell, Brendan K, Ackart, David F, Richardson, Michael A, DiLisio, James E, Pulford, Bruce, Basaraba, Randall J

“…Type 2 diabetes is a leading cause of morbidity and mortality among noncommunicable diseases, and additional animal models that more closely replicate the…”
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Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells by Desmond, Luke W, Holbrook, Evan M, Wright, Caelan T O, Zambrano, Cristian A, Stamper, Christopher E, Bohr, Adam D, Frank, Matthew G, Podell, Brendan K, Moreno, Julie A, MacDonald, Andrew S, Reber, Stefan O, Hernández-Pando, Rogelio, Lowry, Christopher A

“…Previous studies have shown that the in vivo administration of soil-derived bacteria with anti-inflammatory and immunoregulatory properties, such as NCTC…”
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Preparation Strategies of the Anti-Mycobacterial Drug Bedaquiline for Intrapulmonary Routes of Administration by Maloney, Sara E, Stewart, Ian E, Podell, Brendan K, Gary, Hadley E, Mecham, Jeffrey B, Berube, Bryan J, Baldwin, Susan L, Coler, Rhea N, Hickey, Anthony J

“…( ) has infected one-quarter of the world's population and led to the deaths of 1.6 million individuals in 2021 according to estimates from the World Health…”
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2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability by Jeon, Albert B, Obregón-Henao, Andrés, Ackart, David F, Podell, Brendan K, Belardinelli, Juan M, Jackson, Mary, Nguyen, Tuan V, Blackledge, Meghan S, Melander, Roberta J, Melander, Christian, Johnson, Benjamin K, Abramovitch, Robert B, Basaraba, Randall J

“…There is an urgent need to develop new drug treatment strategies to control the global spread of drug-sensitive and multidrug-resistant Mycobacterium…”
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Non-diabetic hyperglycemia exacerbates disease severity in Mycobacterium tuberculosis infected guinea pigs by Podell, Brendan K, Ackart, David F, Kirk, Natalie M, Eck, Sarah P, Bell, Christopher, Basaraba, Randall J

“…Hyperglycemia, the diagnostic feature of diabetes also occurs in non-diabetics associated with chronic inflammation and systemic insulin resistance. Since the…”
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Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection by Butler, Molly, Chotiwan, Nunya, Brewster, Connie D, DiLisio, James E, Ackart, David F, Podell, Brendan K, Basaraba, Randall J, Perera, Rushika, Quackenbush, Sandra L, Rovnak, Joel

“…Dengue virus infection is associated with the upregulation of metabolic pathways within infected cells. This effect is common to infection by a broad array of…”
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A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge Model by Ragan, Izabela K, Hartson, Lindsay M, Dutt, Taru S, Obregon-Henao, Andres, Maison, Rachel M, Gordy, Paul, Fox, Amy, Karger, Burton R, Cross, Shaun T, Kapuscinski, Marylee L, Cooper, Sarah K, Podell, Brendan K, Stenglein, Mark D, Bowen, Richard A, Henao-Tamayo, Marcela, Goodrich, Raymond P

“…The COVID-19 pandemic has generated intense interest in the rapid development and evaluation of vaccine candidates for this disease and other emerging…”
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Enhanced Anti- Mycobacterium tuberculosis Immunity over Time with Combined Drug and Immunotherapy Treatment by Larsen, Sasha E, Baldwin, Susan L, Orr, Mark T, Reese, Valerie A, Pecor, Tiffany, Granger, Brian, Dubois Cauwelaert, Natasha, Podell, Brendan K, Coler, Rhea N

“…It is estimated that one third of the world's population is infected with ( ). This astounding statistic, in combination with costly and lengthy treatment…”
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COMPUTED TOMOGRAPHIC APPEARANCE OF PRIMARY LUNG TUMORS IN DOGS by MAROLF, ANGELA J, GIBBONS, DEBRA S, PODELL, BRENDAN K, PARK, RICHARD D

“…Canine primary lung tumors typically appear radiographically as a well-circumscribed solitary mass in the periphery of a caudal lung lobe. Consolidated and…”
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