Search Results - "Podd, Andrew"
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1
Critical role for mouse marginal zone B cells in PF4/heparin antibody production
Published in Blood (25-04-2013)“…Heparin-induced thrombocytopenia (HIT) is an immune-mediated disorder that can cause fatal arterial or venous thrombosis/thromboembolism. Immune complexes…”
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Journal Article -
2
A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development
Published in Blood (01-05-2008)“…B-cell development is orchestrated by complex signaling networks. Rap1 is a member of the Ras superfamily of small GTP-binding proteins and has 2 isoforms,…”
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Journal Article -
3
STAT5 Protein Negatively Regulates T Follicular Helper (Tfh) Cell Generation and Function
Published in The Journal of biological chemistry (30-03-2012)“…Recent work has identified a new subset of CD4+ T cells named as Tfh cells that are localized in germinal centers and critical in germinal center formation…”
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Journal Article -
4
Prevalence of Low VWF, VWD, and Isolated Collagen Binding Defects in Subjects Undergoing Evaluation for VWD
Published in Blood (03-12-2015)“…Laboratory testing of von Willebrand disease (VWD) continues to be a complicated and much debated subject. There are multiple tests recommended to assess…”
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Journal Article -
5
Development and Validation of a Chromogenic Direct Thrombin Inhibitor Assay on the ACL Top 700 for Quantifying Dabigatran Levels in Plasma
Published in Blood (06-12-2014)“…Dabigatran is a potent, competitive, and reversible direct thrombin inhibitor, that binds to the active site of thrombin, inhibiting both free and clot-bound…”
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Journal Article -
6
A critical role of TAK1 in B-cell receptor–mediated nuclear factor κB activation
Published in Blood (07-05-2009)“…The kinase TAK1 is essential for T-cell receptor (TCR)–mediated nuclear factor κB (NF-κB) activation and T-cell development. However, the role of TAK1 in…”
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Journal Article -
7
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells
Published in The Journal of immunology (1950) (01-12-2012)“…Anergy is a key physiological mechanism for restraining self-reactive B cells. A marked portion of peripheral B cells are anergic B cells that largely depend…”
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Journal Article -
8
Critical Role for Mouse Marginal Zone B Cells in PF4/Heparin Antibody Production
Published in Blood (16-11-2012)“…Abstract 1175 Heparin-induced thrombocytopenia (HIT) is an immune-mediated disorder that can cause fatal arterial or venous thrombosis/thromboembolism. Immune…”
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Journal Article -
9
Stat5 Is Essential for Early B Cell Development but Not for B Cell Maturation and Function
Published in Journal of Immunology (15-07-2007)“…The two closely related Stat5 (Stat5A and Stat5B) proteins are activated by a broad spectrum of cytokines. However, with the complication of the involvement of…”
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Journal Article -
10
STAT5 controls Tfh development (121.19)
Published in The Journal of immunology (1950) (01-05-2012)“…Abstract Recent work has identified a new subset of CD4+ T cells named as T follicular helper (Tfh) cells that are localized in germinal centers and critical…”
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Journal Article -
11
Nuclear Export of the NF-κB Inhibitor IκBα Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation
Published in Immunity (Cambridge, Mass.) (25-02-2011)“…The N-terminal nuclear export sequence (NES) of inhibitor of nuclear factor kappa B (NF-κB) alpha (IκBα) promotes NF-κB export from the cell nucleus to the…”
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Journal Article -
12
Critical role of Bcl10 in BAFF-regulated NF-κB activation and survival of anergic B cells
Published in The Journal of immunology (1950) (19-10-2012)“…Anergy is a key physiological mechanism for restraining self-reactive B cells. A marked portion of peripheral B cells are anergic B cells that largely depend…”
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Journal Article -
13
Nuclear Export of the NF-κB Inhibitor IκBα Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation
Published in Immunity (Cambridge, Mass.) (25-03-2011)Get full text
Journal Article -
14
Nuclear Export of the NF-[kappa]B Inhibitor I[kappa]B[alpha] Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation
Published in Immunity (Cambridge, Mass.) (25-03-2011)Get full text
Journal Article -
15
Nuclear Export of the NF-[kappa]B Inhibitor I[kappa]B[alpha] Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation
Published in Immunity (Cambridge, Mass.) (25-02-2011)“…The N-terminal nuclear export sequence (NES) of inhibitor of nuclear factor kappa B (NF-κB) alpha (IκBα) promotes NF-κB export from the cell nucleus to the…”
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Journal Article -
16
Characterization of the roles of STAT5 and TAK1 in memory B cell generation and homeostasis
Published 01-01-2013“…Memory B cells are a mature population of B cells which emerge from selection following antigen challenge. Memory B cells prevent repeated infections by…”
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Dissertation -
17
A critical role of Rap16 in B-cell trafficking and marginal zone B-cell development
Published in Blood (2008)Get full text
Journal Article -
18
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation
Published in Blood (07-05-2009)“…The kinase TAK1 is essential for T-cell receptor (TCR)-mediated nuclear factor kappaB (NF-kappaB) activation and T-cell development. However, the role of TAK1…”
Get full text
Journal Article -
19
Characterization of the roles of STAT5 and TAK1 in memory B cell generation and homeostasis
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Dissertation