Search Results - "Pocock, J M"

Microglial secreted cathepsin B induces neuronal apoptosis by Kingham, P. J., Pocock, J. M.

“…Activated microglia release a number of substances that can influence neuronal signalling and survival. Here we report that microglia stimulated with the…”
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Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up‐regulated in Alzheimer's disease by Taylor, D. L., Diemel, L. T., Cuzner, M. L., Pocock, J. M.

“…Regulation of microglial reactivity and neurotoxicity is critical for neuroprotection in neurodegenerative diseases. Here we report that microglia possess…”
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Apoptotic Pathways Mobilized in Microglia and Neurones as a Consequence of Chromogranin A‐Induced Microglial Activation by Kingham, P. J., Cuzner, M. L., Pocock, J. M.

“…: Senile plaques of Alzheimer's brain are characterized by activated microglia and immunoreactivity for the peptide chromogranin A. We have investigated the…”
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Septic arthritis of the hip in a Cambodian child caused by multidrug-resistant Salmonella enterica serovar Typhi with intermediate susceptibility to ciprofloxacin treated with ceftriaxone and azithromycin by Pocock, J. M., Khun, P. A., Moore, C. E., Vuthy, S., Stoesser, N., Parry, C. M.

“…Septic arthritis is a rare complication of typhoid fever. A 12-year-old boy without pre-existing disease attended a paediatric hospital in Cambodia with fever…”
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Assessment of anti-TNF-α efficacy in rheumatoid arthritis: is 3 months sufficient? by Pocock, J. M., Vasconcelos, J. C., Östör, A. J. K.

“…Objectives. The optimal therapeutic trial duration of anti-TNF-α therapy is currently unknown. The British Society for Rheumatology (BSR) guidance states that…”
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Microglial Apoptosis Induced by Chromogranin A Is Mediated by Mitochondrial Depolarisation and the Permeability Transition but Not by Cytochrome c Release by Kingham, Paul J., Pocock, Jennifer M.

“…: Chromogranin A is up‐regulated in the senile plaques of Alzheimer's brain and is a novel activator of microglia, transforming them to a neurotoxic phenotype…”
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Modulation of ion gradients and glutamate release in cultured cerebellar granule cells by ouabain by Cousin, M A, Nicholls, D G, Pocock, J M

“…Upon addition of the cardiac glycoside ouabain to cultured cerebellar granule cells, an immediate increase in intracellular free sodium is evoked mediated by…”
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Patterns of infection by Salmonella and Yersinia spp. in commensal house mouse (Mus musculus domesticus) populations by Pocock, M.J.O, Searle, J.B, Betts, W.B, White, P.C.L

“…Aims: This study sought to examine the risk posed by house mice transmitting pathogens to livestock on typical mixed-agriculture farms in the UK. Methods and…”
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Exocytotic and Nonexocytotic Modes of Glutamate Release from Cultured Cerebellar Granule Cells During Chemical Ischaemia by Pocock, Jennifer M., Nicholls, David G.

“…: The mechanism of glutamate release from cultured cerebellar granule neurones in response to a chemical model of ischaemia (10 mM 2‐deoxyglucose plus 1 mM…”
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Activation of Microglial Group III Metabotropic Glutamate Receptors Protects Neurons against Microglial Neurotoxicity by Taylor, Deanna L, Diemel, Lara T, Pocock, Jennifer M

“…A reduction in microglial activation and subsequent neurotoxicity may prove critical for neuroprotection in neurodegenerative diseases. We examined the…”
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Hematite spherules at Meridiani: Results from MI, Mini-TES, and Pancam by Calvin, W. M., Shoffner, J. D., Johnson, J. R., Knoll, A. H., Pocock, J. M., Squyres, S. W., Weitz, C. M., Arvidson, R. E., Bell III, J. F., Christensen, P. R., de Souza Jr, P. A., Farrand, W. H., Glotch, T. D., Herkenhoff, K. E., Jolliff, B. L., Knudson, A. T., McLennan, S. M., Rogers, A. D., Thompson, S. D.

“…We report on observations of hematite‐bearing spherules at Meridiani Planum made using the Microscopic Imager (MI), Mini‐Thermal Emission Spectrometer…”
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Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease by Dale, Russell C., Candler, Paul M., Church, Andrew J., Wait, Robin, Pocock, Jennifer M., Giovannoni, Gavin

“…Infection with the Group A Streptococcus (GAS) can result in immune mediated brain disease characterised by a spectrum of movement and psychiatric disorders…”
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Flunarizine inhibits both calcium-dependent and -independent release of glutamate from synaptosomes and cultured neurones by Cousin, M A, Nicholls, D G, Pocock, J M

“…Flunarizine, an established Ca2+ channel antagonist, blocks both exocytotic glutamate release from mammalian cultured cerebellar granule cells and isolated…”
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The calcium channel coupled to the exocytosis of L-glutamate from cerebellar granule cells is inhibited by the spider toxin, Aga-GI by Pocock, J M, Cousin, M A, Nicholls, D G

“…The increase in cytosolic calcium, [Ca2+]c, evoked with 50 mM KCl in cerebellar granule cells consists of four components; (1) a rapidly inactivating transient…”
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Cannabinoids inhibit neurodegeneration in models of multiple sclerosis by Pryce, Gareth, Ahmed, Zubair, Hankey, Deborah J. R., Jackson, Samuel J., Croxford, J. Ludovic, Pocock, Jennifer M., Ledent, Catherine, Petzold, Axel, Thompson, Alan J., Giovannoni, Gavin, Cuzner, M. Louise, Baker, David

“…Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is triggered by inflammatory attack of the CNS. As yet there is no…”
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Glutamate exocytosis from cerebellar granule cells : the mechanism of a transition to an L-type Ca2+ channel coupling by POCOCK, J. M, COUSIN, M. A, PARKIN, J, NICHOLLS, D. G

“…When cerebellar granule cells in the presence of 1.3 mM calcium chloride (Ca2+) are depolarized by high potassium chloride (KCl), the release of endogenous…”
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Omega-agatoxins differentially block calcium channels in locust, chick and rat synaptosomes by Pocock, J M, Venema, V J, Adams, M E

“…Three toxins (omega-Agatoxins IA, IIA and IIIA) isolated from the venom of the funnel web spider, Agelenopsis aperta, differentially block…”
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Neurotransmitter receptors on microglia by Pocock, Jennifer M, Kettenmann, Helmut

“…Microglia are the intrinsic immune cells of the brain and express chemokine and cytokine receptors that interact with the peripheral immune cells. Recent…”
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Branched chain amino acids induce apoptosis in neural cells without mitochondrial membrane depolarization or cytochrome c release: implications for neurological impairment associated with maple syrup urine disease by Jouvet, P, Rustin, P, Taylor, D L, Pocock, J M, Felderhoff-Mueser, U, Mazarakis, N D, Sarraf, C, Joashi, U, Kozma, M, Greenwood, K, Edwards, A D, Mehmet, H

“…Maple syrup urine disease (MSUD) is an inborn error of metabolism caused by a deficiency in branched chain alpha-keto acid dehydrogenase that can result in…”
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Intracellular free Ca2+ responses in electrically stimulated cerebellar granule cells by Cousin, M A, Pocock, J M, Nicholls, D G

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