Search Results - "Pockley, Alan G"

The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation by Multhoff, Gabriele, Pockley, Alan G, Schmid, Thomas E, Schilling, Daniela

“…Highlights • Low dose irradiation induces the synthesis of heat shock proteins (HSPs). • Low dose irradiation increases the cell surface expression of HSPs on…”
Get full text

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody by Stangl, Stefan, Gehrmann, Mathias, Riegger, Julia, Kuhs, Kristin, Riederer, Isabelle, Sievert, Wolfgang, Hube, Kathrin, Mocikat, Ralph, Dressel, Ralf, Kremmer, Elisabeth, Pockley, Alan G., Friedrich, Lars, Vigh, Laszlo, Skerra, Arne, Multhoff, Gabriele, Kondorosi, Eva

“…Immunization of mice with a 14-mer peptide TKDNNLLGRFELSG, termed "TKD," comprising amino acids 450–461 (aa 450–461 ) in the C terminus of inducible Hsp70,…”
Get full text

Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells by Schilling, Daniela, Gehrmann, Mathias, Steinem, Claudia, De Maio, Antonio, Pockley, Alan G, Abend, Michael, Molls, Michael, Multhoff, Gabriele

“…Hypoxia is well known to limit curability of tumors by ionizing radiation. Here, we show that hypoxia treatment of tumor cells causes coexpression of heat…”
Get full text

Membrane Hsp70-A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition by Breuninger, Stephanie, Stangl, Stefan, Werner, Caroline, Sievert, Wolfgang, Lobinger, Dominik, Foulds, Gemma A, Wagner, Sarah, Pickhard, Anja, Piontek, Guido, Kokowski, Konrad, Pockley, Alan G, Multhoff, Gabriele

“…The presence of circulating tumor cells (CTCs) in the peripheral blood is a pre-requisite for progression, invasion, and metastatic spread of cancer…”
Get full text

Tumor imaging and targeting potential of an Hsp70-derived 14-mer peptide by Gehrmann, Mathias, Stangl, Stefan, Foulds, Gemma A, Oellinger, Rupert, Breuninger, Stephanie, Rad, Roland, Pockley, Alan G, Multhoff, Gabriele

“…We have previously used a unique mouse monoclonal antibody cmHsp70.1 to demonstrate the selective presence of a membrane-bound form of Hsp70 (memHsp70) on a…”
Get full text

Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B by Gehrmann, Mathias, Stangl, Stefan, Kirschner, Andreas, Foulds, Gemma A, Sievert, Wolfgang, Doss, Brigitte T, Walch, Axel, Pockley, Alan G, Multhoff, Gabriele

“…We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a…”
Get full text

SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis by Abdel-Fatah, Tarek M A, PhD, Agarwal, Devika, MSc, Liu, Dong-Xu, PhD, Russell, Roslin, PhD, Rueda, Oscar M, PhD, Liu, Karen, MSc, Xu, Bing, PhD, Moseley, Paul M, BSc, Green, Andrew R, PhD, Pockley, Alan G, Prof, Rees, Robert C, Prof, Caldas, Carlos, Prof, Ellis, Ian O, Prof, Ball, Graham R, Prof, Chan, Stephen Y T, Prof

“…Summary Background Proliferation markers and profiles have been recommended for guiding the choice of systemic treatments for breast cancer. However, the best…”
Get full text

A novel expression and purification system for the production of enzymatic and biologically active human granzyme B by Gehrmann, Mathias, Doß, Brigitte T., Wagner, Michaela, Zettlitz, Kirstin A., Kontermann, Roland E., Foulds, Gemma, Pockley, Alan G., Multhoff, Gabriele

“…The serine protease granzyme B (grB) has previously been shown to induce perforin-independent apoptosis in membrane Hsp70 positive tumor cells in a number of…”
Get full text

Influence of Hsp70 and HLA-E on the Killing of Leukemic Blasts by Cytokine/Hsp70 Peptide-Activated Human Natural Killer (NK) Cells by Stangl, Stefan, Gross, Catharina, Pockley, Alan G., Asea, Alexzander A., Multhoff, Gabriele

“…This study compared the effects of the human 70-kDa stress protein (Hsp70) peptide, TKDNNLL GRFELSG (TKD), proinflammatory cytokines, or a combination of both…”
Get full text

Leptin indirectly activates human neutrophils via induction of TNF-alpha by Zarkesh-Esfahani, Hamid, Pockley, Alan G, Wu, Zida, Hellewell, Paul G, Weetman, Anthony P, Ross, Richard J M

“…Leptin, the satiety hormone, appears to act as a link between nutritional status and immune function. It has been shown to elicit a number of immunoregulatory…”
Get full text

Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension by POCKLEY, Alan G, GEORGIADES, Anastasia, THULIN, Thomas, DE FAIRE, Ulf, FROSTEGARD, Johan

“…Although heat shock proteins (Hsp's) are present in the sera of healthy individuals and at elevated levels in subjects with early cardiovascular disease, their…”
Get full text

Improvement in Nutritional Status Reduces the Clinical Impact of Infections in Older Adults by Forster, Sarah E., Powers, Hilary J., Foulds, Gemma A., Flower, Daniel J., Hopkinson, Kay, Parker, Stuart G., Young, Tracey A., Saxton, John, Pockley, Alan G., Williams, Elizabeth A.

“…Objectives To determine the effect of a dietary intervention and micronutrient supplementation on self‐reported infections in older adults. Design A…”
Get full text

Frontiers research topic: radiation-induced effects and the immune system by Multhoff, Gabriele, Rödel, Franz, Pockley, Alan G, Gaipl, Udo S

Get full text

Association of Sperm-Associated Antigen 5 and Treatment Response in Patients With Estrogen Receptor-Positive Breast Cancer by Abdel-Fatah, Tarek M A, Ball, Graham R, Thangavelu, Pulari U, Reid, Lynne E, McCart Reed, Amy E, Saunus, Jodi M, Duijf, Pascal H G, Simpson, Peter T, Lakhani, Sunil R, Pongor, Lorinc, Gyorffy, Balázs, Moseley, Paul M, Green, Andrew R, Pockley, Alan G, Caldas, Carlos, Ellis, Ian O, Chan, Stephen Y T

“…There is no proven test that can guide the optimal treatment, either endocrine therapy or chemotherapy, for estrogen receptor-positive breast cancer. To…”
Get full text

Influence of tumors on protective anti-tumor immunity and the effects of irradiation by Foulds, Gemma A, Radons, Jürgen, Kreuzer, Mira, Multhoff, Gabriele, Pockley, Alan G

“…Innate and adaptive immunity plays important roles in the development and progression of cancer and it is becoming apparent that tumors can influence the…”
Get full text

Identification of a rat bone marrow-derived dendritic cell population which secretes both IL-10 and IL-12: Evidence against a reciprocal relationship between IL-10 and IL-12 secretion by Muthana, Munitta, Fairburn, Barbara, Mirza, Shabana, Slack, Laura K., Hopkinson, Kay, Pockley, Alan G.

“…The qualitative nature of immune responses induced by dendritic cells (DCs) is influenced by the balance of pro-inflammatory (e.g. IL-12) and anti-inflammatory…”
Get full text

Response: Is Low-Heat Shock Protein 70 a Primary or a Secondary Event in the Development of Atherosclerosis? by Pockley, Alan G., Georgiades, Anastasia, Thulin, Thomas, de Faire, Ulf, Frostegård, Johan

Get full text

Frontiers Research Topics OncologyFrontiers Research Topic: Radiation-induced effects and the immune system by Gabriele eMulthoff, Udo S Gaipl, Franz eRödel, Alan G Pockley

Get full text

Response: Is Low-Heat Shock Protein 70 a Primary or a Secondary Event in the Development of Atherosclerosis? by Pockley, Alan G, Georgiades, Anastasia, Thulin, Thomas, de Faire, Ulf, Frostegård, Johan

Get full text

Effect of anti-CD4 monoclonal antibody administration on rat small bowel allograft survival and circulating leukocyte populations by Bowles, M J, Pockley, A G, Wood, R F

“…This study assessed the effect of an anti-rat CD4 monoclonal antibody (OX38) on heterotopic small bowel allograft rejection. Fully allogeneic small bowel…”
Get more information