Search Results - "Pocar, Donato"

An efficient synthesis of new diastereomeric enantiopure 1-aminocyclopentane-1,2,4-tricarboxylic acids by Caputo, Francesco, Clerici, Francesca, Gelmi, Maria Luisa, Pellegrino, Sara, Pocar, Donato

“…Novel 1-aminocyclopentane-1,2,4-tricarboxylic acids 11 and 14 containing the glutamic acid skeleton were prepared as two diastereomers characterized by having…”
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Synthesis of 2-Amino-5-sulfanyl-1,3,4-thiadiazole Derivatives and Evaluation of Their Antidepressant and Anxiolytic Activity by Clerici, Francesca, Pocar, Donato, Guido, Maddalena, Loche, Antonella, Perlini, Vincenzo, Brufani, Mario

“…Recently a series of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives bearing different substituents were synthesized and screened pharmacologically in order…”
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5(4H)-Oxazolones. Part VIII.1 An Efficient Synthesis of Δ1-Pyrroline-2-carboxylic Acid derivatives through Michael and Wittig condensation by Clerici, Francesca, Gelmi, Maria L., Pocar, Donato, Rondena, Roberta

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Single step synthesis of 2,3-dialkyl-6-nitro-quinazolin-4(3 H)-imines and 3,5-dialkyl-9-nitro-imidazo[1,2- c]quinazolin-2(3 H)-ones by Erba, Emanuela, Pocar, Donato, Trimarco, Pasqualina

“…A single step synthesis of 2,3-dialkyl-6-nitro-quinazolin-4(3 H)-imines and 3,5-dialkyl-9-nitro-imidazo-[1,2- c]-quinazolin-2(3 H)-ones from simple carbonyl…”
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Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein famesylation by FERRI, Nicola, CLERICI, Francesca, YOKOYAMA, Kohei, POCAR, Donato, CORSINI, Alberto

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3-Demethoxy-3-glycosylaminothiocolchicines:  Synthesis of a New Class of Putative Muscle Relaxant Compounds by Gelmi, Maria Luisa, Pocar, Donato, Pontremoli, Guido, Pellegrino, Sara, Bombardelli, Ezio, Fontana, Gabriele, Riva, Antonella, Balduini, Walter, Carloni, Silvia, Cimino, Mauro, Johnson, Francis

“…A novel class of 3-demethoxy-3-glycosylaminothiocolchicines (7) was prepared and tested for muscle relaxant activity. The syntheses were performed starting…”
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Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation by Ferri, Nicola, Clerici, Francesca, Yokoyama, Kohei, Pocar, Donato, Corsini, Alberto

“…Isothiazole dioxides have been shown to inhibit Trypanosoma brucei protein farnesyltransferase (PFTase) in isolated enzyme, but elicited only a minor effect on…”
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Isothiazoles. Part 14: New 3-aminosubstituted isothiazole dioxides and their mono- and dihalogeno derivatives by Clerici, Francesca, Contini, Alessandro, Gelmi, Maria Luisa, Pocar, Donato

“…3-Alkylamino- and 3-arylamino isothiazole dioxides unsubstituted at C-4 and C-5 were synthesized starting from dithiopropionic amides. Taking advantage of the…”
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Isothiazolo[5,4-d]isoxazole S,S-dioxides and pyrazolo [3,4-d]-isothiazole S,S-dioxides through cycloaddition reaction on 3-benzylaminoisothiazole S,S-dioxides by Clerici, Francesca, Gelmi, Maria Luisa, Monzani, Cristiano, Pocar, Donato, Sala, Alessandro

“…By reacting 4,5‐unsubstituted isothiazole dioxides with diazoalkanes and nitrile oxides bicyclic pyrazolo[3,4‐d]isothiazole and isothiazolo[5,4‐d]isoxazole…”
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Selective synthesis of 14β-amino taxanes by Battaglia, Arturo, Baldelli, Eleonora, Bombardelli, Ezio, Carenzi, Giacomo, Fontana, Gabriele, Gelmi, Maria Luisa, Guerrini, Andrea, Pocar, Donato

“…The base induced deprotonation of H-14 of 7-triethylsilyl- (7-TES-) and 7- tert-butoxycarbonyl- (7-BOC-) protected 13-oxo-baccatins gave the corresponding…”
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2-Amidinylindole-3-carbaldehydes: synthesis of new tetracyclic compounds containing the pyrrolo[1,2- c]1,4-diazepine ring by Clerici, Francesca, Erba, Emanuela, Pocar, Donato

“…2-Amidinylindol-3-carbaldehydes bearing an α-alkoxycarbonyl substituent on the cyclic-tertiary amine moiety were prepared. Pyrolysis of these amidines in…”
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Novel 3-O-Glycosyl-3-demethylthiocolchicines as Ligands for Glycine and γ-Aminobutyric Acid Receptors by Gelmi, Maria Luisa, Fontana, Gabriele, Pocar, Donato, Pontremoli, Guido, Pellegrino, Sara, Bombardelli, Ezio, Riva, Antonella, Balduini, Walter, Carloni, Silvia, Cimino, Mauro

“…New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on γ-aminobutyric acid (GABA) and…”
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2-Amidinylindole-3-carbaldehydes: Versatile Synthons for the Preparation of α-Carboline Derivatives by Erba, Emanuela, Luisa Gelmi, M, Pocar, Donato

“…The 2-amidinylindole-3-carbaldehydes 1 are the key starting materials for the preparation of three classes of carbolines 2, 6 and 7 in which the pyridine ring…”
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Diastereoselective 14β-Hydroxylation of Baccatin III Derivatives by Baldelli, Eleonora, Battaglia, Arturo, Bombardelli, Ezio, Carenzi, Giacomo, Fontana, Gabriele, Gambini, Andrea, Gelmi, Maria Luisa, Guerrini, Andrea, Pocar, Donato

“…14β-Hydroxybaccatin III, a compound with limited availability by natural sources, is the starting material for the synthesis of the second-generation…”
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New Taxane Derivatives:  Synthesis of Baccatin[14,1-d]furan-2-one Nucleus and Its Condensation with the Norstatine Side Chain by Baldelli, Eleonora, Battaglia, Arturo, Bombardelli, Ezio, Carenzi, Giacomo, Fontana, Gabriele, Gelmi, Maria Luisa, Guerrini, Andrea, Pocar, Donato

“…New taxanes 15 and 18, containing the unsaturated and saturated baccatin[14,1-d]furan-2-one nucleus, respectively, were prepared starting from the readily…”
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Diastereoselective 14beta-hydroxylation of baccatin III derivatives by Baldelli, Eleonora, Battaglia, Arturo, Bombardelli, Ezio, Carenzi, Giacomo, Fontana, Gabriele, Gambini, Andrea, Gelmi, Maria Luisa, Guerrini, Andrea, Pocar, Donato

“…14beta-Hydroxybaccatin III, a compound with limited availability by natural sources, is the starting material for the synthesis of the second-generation…”
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Masked constrained cysteines: diastereoselective and enantioselective synthesis of 1-amino-2-mercaptocyclopropanecarboxylic acid derivatives by Clerici, Francesca, Gelmi, Maria Luisa, Pocar, Donato, Pilati, Tullio

“…A diastereoselective and enantioselective synthesis of ( Z)-1-benzoylamino-2-tritylsulfanylcyclopropanecarboxylic acid derivatives 8a, b and 9a, b was achieved…”
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Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase by Clerici, Francesca, Gelmi, Maria Luisa, Yokoyama, Kohei, Pocar, Donato, Van Voorhis, Wesley C., Buckner, Frederick S., Gelb, Michael H.

“…A series of isothiazole dioxides was synthesized and evaluated as inhibitors of protein farnesyltransferase from the parasite that causes African sleeping…”
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Isothiazoles. Part VI. Cycloaddition of azides to isothiazole dioxides: Synthesis of thiadiazabicyclo[3.1.0]hexene derivatives and their thermal rearrangement to thiazete dioxides, 1,2,6-thiadiazine dioxides and pyrazoles by Clerici, Francesca, Galletti, Franco, Pocar, Donato, Roversi, Pietro

“…3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide ( 1) was made to react with arylalkyl- and arylazides 2. Cycloadducts 3, which could be isolated in…”
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N-Deacetyl-N-aminoacylthiocolchicine Derivatives:  Synthesis and Biological Evaluation on MDR-Positive and MDR-Negative Human Cancer Cell Lines by Gelmi, Maria Luisa, Mottadelli, Sabrina, Pocar, Donato, Riva, Antonella, Bombardelli, Ezio, De Vincenzo, Rosa, Scambia, Giovanni

“…A new series of N-deacetyl-N-(N-trifluoroacetylaminoacyl)thiocolchicine derivatives 9−15 have been synthesized starting from the corresponding…”
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