Search Results - "Pober, Jordan S"

Inflammation and the blood microvascular system by Pober, Jordan S, Sessa, William C

“…Acute and chronic inflammation is associated with changes in microvascular form and function. At rest, endothelial cells maintain a nonthrombogenic,…”
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Evolving functions of endothelial cells in inflammation by Pober, Jordan S, Sessa, William C

“…Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes. Microvascular endothelial cells at a site of inflammation are both…”
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Inflammatory and Immune Responses in the Arterial Media by Tellides, George, Pober, Jordan S

“…Inflammatory arterial diseases differentially affect the compartments of the vessel wall. The intima and adventitia are commonly involved by the disease…”
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Participation of blood vessel cells in human adaptive immune responses by Pober, Jordan S, Tellides, George

“…Circulating T cells contact blood vessels either when they extravasate across the walls of microvessels into inflamed tissues or when they enter into the walls…”
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Antigen Presentation by Vascular Cells by Pober, Jordan S, Merola, Jonathan, Liu, Rebecca, Manes, Thomas D

“…Antigen presentation by cells of the vessel wall may initiate rapid and localized memory immune responses in peripheral tissues. Peptide antigens displayed on…”
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Cutting Edge: TNF-Induced MicroRNAs Regulate TNF-Induced Expression of E-Selectin and Intercellular Adhesion Molecule-1 on Human Endothelial Cells: Feedback Control of Inflammation by Suarez, Yajaira, Wang, Chen, Manes, Thomas D, Pober, Jordan S

“…MicroRNAs (miRNAs) pair with target sequences in the 3' untranslated region of mRNAs to posttranscriptionally repress gene expression. In this study, we report…”
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Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells by Suárez, Yajaira, Fernández-Hernando, Carlos, Pober, Jordan S, Sessa, William C

“…Dicer is a key enzyme involved in the maturation of microRNAS (miRNAs). miRNAs have been shown to be regulators of gene expression participating in the control…”
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Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells by Cui, Jiajia, Qin, Lingfeng, Zhang, Junwei, Abrahimi, Parwiz, Li, Hong, Li, Guangxin, Tietjen, Gregory T., Tellides, George, Pober, Jordan S., Mark Saltzman, W.

“…Human endothelial cells are initiators and targets of the rejection response. Pre-operative modification of endothelial cells by small interfering RNA…”
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SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling by Xu, Yue, Zhang, Haifeng, Chen, Yuxin, Pober, Jordan S., Zhou, Min, Zhou, Jenny Huanjiao, Min, Wang

“…Serum response factor (SRF) controls gene transcription in vascular smooth muscle cells (VSMCs) and regulates VSMC phenotypic switch from a contractile to a…”
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Costimulators expressed on human endothelial cells modulate antigen-dependent recruitment of circulating T lymphocytes by Manes, Thomas D., Wang, Vivian, Pober, Jordan S.

“…Endothelial cells (ECs) can present antigens to circulating effector memory T cells (T EM ) and to regulatory T cells (T regs), triggering antigen-specific…”
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Mechanisms of endothelial dysfunction, injury, and death by Pober, Jordan S, Min, Wang, Bradley, John R

“…Vascular endothelial cells normally perform several key homeostatic functions such as keeping blood fluid, regulating blood flow, regulating macromolecule and…”
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Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis by Moledina, Dennis G, Obeid, Wassim, Smith, Rex N, Rosales, Ivy, Sise, Meghan E, Moeckel, Gilbert, Kashgarian, Michael, Kuperman, Michael, Campbell, Kirk N, Lefferts, Sean, Meliambro, Kristin, Bitzer, Markus, Perazella, Mark A, Luciano, Randy L, Pober, Jordan S, Cantley, Lloyd G, Colvin, Robert B, Wilson, F Perry, Parikh, Chirag R

“…BackgroundAcute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney injury with diagnosis-specific treatment options. However, due to…”
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Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis by Suárez, Yajaira, Fernández-Hernando, Carlos, Yu, Jun, Gerber, Scott A, Harrison, Kenneth D, Pober, Jordan S, Iruela-Arispe, M. Luisa, Merkenschlager, Matthias, Sessa, William C

“…Posttranscriptional gene regulation by microRNAs (miRNAs) is important for many aspects of development, homeostasis, and disease. Here, we show that reduction…”
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A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells by Li, Xue, Jiang, Quan, Song, Guiyu, Barkestani, Mahsa Nouri, Wang, Qianxun, Wang, Shaoxun, Fan, Matthew, Fang, Caodi, Jiang, Bo, Johnson, Justin, Geirsson, Arnar, Tellides, George, Pober, Jordan S., Jane-wit, Dan

“…Internalization of complement membrane attack complexes (MACs) assembles NLRP3 inflammasomes in endothelial cells (EC) and promotes IL-β-mediated tissue…”
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Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling by Roh, Jason D, Sawh-Martinez, Rajendra, Brennan, Matthew P, Jay, Steven M, Devine, Lesley, Rao, Deepak A, Yi, Tai, Mirensky, Tamar L, Nalbandian, Ani, Udelsman, Brooks, Hibino, Narutoshi, Shinoka, Toshiharu, Saltzman, W. Mark, Snyder, Edward, Kyriakides, Themis R, Pober, Jordan S, Breuer, Christopher K

“…Biodegradable scaffolds seeded with bone marrow mononuclear cells (BMCs) are the earliest tissue-engineered vascular grafts (TEVGs) to be used clinically…”
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Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis by Egozi, Adi, Olaloye, Oluwabunmi, Werner, Lael, Silva, Tatiana, McCourt, Blake, Pierce, Richard W, An, Xiaojing, Wang, Fujing, Chen, Kong, Pober, Jordan S, Shouval, Dror, Itzkovitz, Shalev, Konnikova, Liza

“…Necrotizing enterocolitis (NEC) is a gastrointestinal complication of premature infants with high rates of morbidity and mortality. A comprehensive view of the…”
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Author Correction: A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells by Li, Xue, Jiang, Quan, Song, Guiyu, Barkestani, Mahsa Nouri, Wang, Qianxun, Wang, Shaoxun, Fan, Matthew, Fang, Caodi, Jiang, Bo, Johnson, Justin, Geirsson, Arnar, Tellides, George, Pober, Jordan S., Jane-wit, Dan

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Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages by Araldi, Elisa, Fernández-Fuertes, Marta, Canfrán-Duque, Alberto, Tang, Wenwen, Cline, Gary W., Madrigal-Matute, Julio, Pober, Jordan S., Lasunción, Miguel A., Wu, Dianqing, Fernández-Hernando, Carlos, Suárez, Yajaira

“…Macrophages perform critical functions in both innate immunity and cholesterol metabolism. Here, we report that activation of Toll-like receptor 4 (TLR4) in…”
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Efficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9 by Abrahimi, Parwiz, Chang, William G, Kluger, Martin S, Qyang, Yibing, Tellides, George, Saltzman, W Mark, Pober, Jordan S

“…RATIONALE:The participation of endothelial cells (EC) in many physiological and pathological processes is widely modeled using human EC cultures, but genetic…”
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Author Correction: A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells by Li, Xue, Jiang, Quan, Song, Guiyu, Barkestani, Mahsa Nouri, Wang, Qianxun, Wang, Shaoxun, Fan, Matthew, Fang, Caodi, Jiang, Bo, Johnson, Justin, Geirsson, Arnar, Tellides, George, Pober, Jordan S., Jane-wit, Dan

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