Search Results - "Pluymers, Wim"

LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells by Maertens, Goedele, Cherepanov, Peter, Pluymers, Wim, Busschots, Katrien, De Clercq, Erik, Debyser, Zeger, Engelborghs, Yves

“…We have reported that human immunodeficiency virus type 1 (HIV-1) integrase (IN) forms a specific nuclear complex with human lens epithelium-derived growth…”
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Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle by Witvrouw, M, Fikkert, V, Pluymers, W, Matthews, B, Mardel, K, Schols, D, Raff, J, Debyser, Z, De Clercq, E, Holan, G, Pannecouque, C

“…Polyanionic dendrimers were synthesized and evaluated for their antiviral effects. Phenyldicarboxylic acid (BRI6195) and naphthyldisulfonic acid (BRI2923)…”
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Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters by Pluymers, W, Neamati, N, Pannecouque, C, Fikkert, V, Marchand, C, Burke, Jr, T R, Pommier, Y, Schols, D, De Clercq, E, Debyser, Z, Witvrouw, M

“…The antiviral activity of L-chicoric acid against HIV-1 has been attributed previously to the inhibition of HIV-1 integration. This conclusion was based on the…”
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Inhibition of Human Immunodeficiency Virus Type 1 Integration by Diketo Derivatives by PLUYMERS, Wim, PAIS, Godwin, VAN MAELE, Bénédicte, PANNECOUQUE, Christophe, FIKKERT, Valery, BURKE, Terrence R, DE CLERCQ, Erik, WITVROUW, Myriam, NEAMATI, Nouri, DEBYSER, Zeger

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Identification of chronic myeloid leukemia patients treated with imatinib who are potentially eligible for treatment discontinuation by assessing real-life molecular responses on the international scale in a EUTOS-certified lab by Heinrichs, Amélie, Dessars, Barbara, El Housni, Hakim, Pluymers, Wim, Peeters, Karen, Benghiat, Fleur S., Heimann, Pierre

“…•Real-life molecular responses on international scale in EUTOS-certified laboratory.•53.4% of patients were in deep molecular responses ≥MR4.5 at last…”
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Disease and treatment characteristics of polycythemia vera patients in Belgium: Results from a scientific survey by Devos, Timothy, Beguin, Yves, Noens, Lucien, Eygen, Koen, Zachée, Pierre, Mineur, Philippe, Knoops, Laurent, Doyen, Chantal, Theunissen, Koen, Benghiat, Fleur Samantha, Reusens, Michael, Pluymers, Wim

“…Objective The current survey aimed to gather predefined disease parameters and treatment strategies to characterize the polycythemia vera (PV) patient…”
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Adequate iron chelation therapy for at least six months improves survival in transfusion-dependent patients with lower risk myelodysplastic syndromes by Delforge, Michel, Selleslag, Dominik, Beguin, Yves, Triffet, Agnès, Mineur, Philippe, Theunissen, Koen, Graux, Carlos, Trullemans, Fabienne, Boulet, Dominique, Van Eygen, Koen, Noens, Lucien, Van Steenweghen, Steven, Lemmens, Jan, Pierre, Pascal, D’hondt, Randal, Ferrant, Augustin, Deeren, Dries, Van De Velde, Ann, Wynendaele, Wim, André, Marc, De Bock, Robrecht, Efira, André, Breems, Dimitri, Deweweire, Anne, Geldhof, Kurt, Pluymers, Wim, Harrington, Amanda, MacDonald, Karen, Abraham, Ivo, Ravoet, Christophe

“…Abstract Background Most patients with myelodysplastic syndromes (MDS) require transfusions at the risk of iron overload and associated organ damage, and…”
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Interruption or Discontinuation of Tyrosine Kinase Inhibitor Treatment in Chronic Myeloid Leukaemia: A Retrospective Cohort Study (SPARKLE) in Belgium by Devos, Timothy, Verhoef, Gregor, Steel, Eva, Mazure, Dominiek, Lewalle, Philippe, Bron, Dominique, Berneman, Zwi, Benghiat, Fleur Samantha, Mineur, Philippe, Theunissen, Koen, Zachée, Pierre, Doyen, Chantal, Put, Natalie, Lejeune, Marie, Van Eygen, Koen, Havelange, Violaine, Reusens, Michael, Pluymers, Wim, Peeters, Karen

“…To assess interruptions/discontinuations of tyrosine kinase inhibitor (TKI) treatment in Belgian patients with chronic myeloid leukaemia (CML). This…”
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New Class of HIV Integrase Inhibitors that Block Viral Replication in Cell Culture by Pannecouque, Christophe, Pluymers, Wim, Van Maele, Bénédicte, Tetz, Victor, Cherepanov, Peter, De Clercq, Erik, Witvrouw, Myriam, Debyser, Zeger

“…Background: To improve the existing combination therapies of infection with the human immunodeficiency virus (HIV) and to cope with virus strains that are…”
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Iron status and treatment modalities in transfusion-dependent patients with myelodysplastic syndromes by Delforge, Michel, Selleslag, Dominik, Triffet, Agnès, Mineur, Philippe, Bries, Greet, Graux, Carlos, Trullemans, Fabienne, MacDonald, Karen, Abraham, Ivo, Pluymers, Wim, Ravoet, Christophe

“…Transfusion dependency and iron overload are common among patients with myelodysplastic syndromes (MDS) treated with red blood cell (RBC) transfusions…”
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Myelofibrosis patients in Belgium: disease characteristics by Devos, T., Zachée, P., Bron, D., Noens, L., Droogenbroeck, J. Van, Mineur, P., Beguin, Y., Berneman, Z., Benghiat, F. S., Kentos, A., Chatelain, C., Demuynck, H., Lemmens, J., Eygen, K. Van, Theunissen, K., Trullemans, F., Pierre, P., Pluymers, W., Knoops, L.

“…Objective: To date, only a small number of epidemiological studies on myelofibrosis have been performed. The current study aimed to characterize the…”
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High‐level expression of active HIV‐1 integrase from a synthetic gene in human cells by Cherepanov, Peter, Pluymers, Wim, Claeys, Anje, Proost, Paul, Clercq, Erik, Debyser, Zeger

“…A synthetic gene encoding for HIV‐1 integrase was designed to circumvent the intrinsic instability and the repressor elements present in the wild‐type gene…”
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Nuclear Localization of Human Immunodeficiency Virus Type 1 Integrase Expressed as a Fusion Protein with Green Fluorescent Protein by Pluymers, Wim, Cherepanov, Peter, Schols, Dominique, De Clercq, Erik, Debyser, Zeger

“…Lentiviruses in general and the human immunodeficiency virus type 1 (HIV-1) in particular have the ability to integrate their genome stably into the chromosome…”
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High-level expression of active HIV-1 integrase from a synthetic gene in human cells by CHEREPANOV, P.

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Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells by Van Maele, Bénédicte, Van Eylen, Leen, Pluymers, Wim, Debyser, Zeger

“…Since the integration of viral DNA in the host genome is an essential step in the replication cycle of HIV-1, an active search for inhibitors of the…”
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Activity of recombinant HIV-1 integrase on mini-HIV DNA by Cherepanov, Peter, Surratt, David, Toelen, Jaan, Pluymers, Wim, Griffith, Jack, De Clercq, Erik, Debyser, Zeger

“…Integration of the human immunodeficiency virus type 1 (HIV-1) cDNA into the genome of a human cell is an essential step in the viral replication cycle…”
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Activity of recombinant HIV-1 integrase onmini-HIV DNA by Cherepanov, Peter, Surratt, David, Toelen, Jaan, Pluymers, Wim, Griffith, Jack, De Clercq, Erik, Zeger Debyser

“…Integration of the human immunodeficiency virus type 1 (HIV-1) cDNA into the genome of a human cell is an essential step in the viral replication cycle…”
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Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication by van Griensven, Johan, Zhan, Xiaojing, Van Maele, Bénédicte, Pluymers, Wim, Michiels, Martine, De Clercq, Erik, Cherepanov, Peter, Debyser, Zeger

“…Background HIV‐1 integrase (IN) is an interesting target for the gene therapy of AIDS. Although the in vivo functions are not well characterized, it is thought…”
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Disease and treatment characteristics of polycythaemia vera patients in Belgium : results from a scientific survey by Devos, Timothy, BEGUIN, Yves, Noens, Lucien, Van Eygen, Koen, Zachée, Pierre, Mineur, Philippe, Knoops, Laurent, Doyen, Chantal, Theunissen, Koen, Benghiat, Fleur Samantha, Reusens, Michael, Pluymers, Wim

“…Objective: The current survey aimed to gather predefined disease parameters and treatment strategies to characterize the polycythemia vera (PV) patient…”
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Adequate iron chelation therapy for at least six months improves survival in transfusion-dependent patients wih lower risk myelodysplastic syndromes by Delforge, Michel, Selleslag, Dominik, BEGUIN, Yves, Triffet, Agnès, Mineur, Philippe, Theunissen, Koen, Graux, Carlos, Trullemans, Fabienne, Boulet, Dominique, Van Eygen, Koen, Noens, Lucien, Van Steenweghen, Steven, Lemmens, Jan, Pierre, Pascal, D'Hondt, Randal, Ferrant, Augustin, Deeren, Dries, Van de Velde, Ann, Wynendaeke, Wim, André, Marc, De Bock, Robrecht, Efira, André, Breems, Dimitri, Deweweire, Anne, Geldhof, Kurt, Pluymers, Wim, Harrington, Amanda, MacDonald, Karen, Abraham, Ivo, Ravoet, Christophe

“…Background: Most patients with myelodysplastic syndromes (MDS) require transfusions at the risk of ironoverload and associated organ damage, and death…”
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